| Diskin Orphan Fund of IsraelEIN 13-5608399 | Human Services | NY | $1,817,844Small | 75.86 |
| Do SomethingEIN 13-3720473 | Human Services | NY | $10,095,721Mid-sized | 93.37 |
| Dollar Energy FundEIN 25-1442933 | Human Services | PA | $15,557,633Large | 91.16 |
| Domestic Abuse Intervention ServicesEIN 39-1268238 | Human Services | WI | $3,256,031Small | 93.70 |
| Domestic Abuse ProjectEIN 41-1356278 | Human Services | MN | $1,595,408Small | 76.76 |
| Domestic Abuse Project of Delaware CountyEIN 23-2053144 | Human Services | PA | $1,766,699Small | 90.06 |
| Domestic Violence Center of Chester CountyEIN 22-2606511 | Human Services | PA | $1,767,014Small | 88.49 |
| Domestic Violence Intervention Services, Inc. (DVIS)EIN 73-1028332 | Human Services | OK | $6,638,122Mid-sized | 93.99 |
| Domestic Violence ProjectEIN 34-1263226 | Human Services | OH | $1,759,397Small | 86.59 |
| Domestic Violence Solutions for Santa Barbara CountyEIN 95-3495141 | Human Services | CA | $1,830,345Small | 84.41 |
| Donald W. Reynolds Boys & Girls ClubEIN 71-0254287 | Human Services | AR | $2,246,524Small | 88.23 |
| Doorways for Women and FamiliesEIN 54-1087829 | Human Services | VA | $4,770,512Mid-sized | 93.46 |
| DOROTEIN 13-3264005 | Human Services | NY | $7,626,167Mid-sized | 92.96 |
| Downtown Rescue MissionEIN 63-0735295 | Human Services | AL | $8,473,047Mid-sized | 90.69 |
| Downtown Women's CenterEIN 31-1597223 | Human Services | CA | $10,092,147Mid-sized | 89.78 |
| DREAMEIN 13-4025290 | Human Services | NY | $15,172,457Large | 91.42 |
| Dress for Success HoustonEIN 76-0579697 | Human Services | TX | $2,618,328Small | 94.63 |
| Dress for Success WorldwideEIN 13-4040377 | Human Services | NY | $22,405,064Large | 91.40 |
| DuPage PADSEIN 36-3675494 | Human Services | IL | $4,142,129Mid-sized | 90.86 |
| Durham Rescue MissionEIN 58-1482590 | Human Services | NC | $11,976,198Mid-sized | 100.00 |
| Eagle RanchEIN 58-1497408 | Human Services | GA | $4,667,626Mid-sized | 93.88 |
| Eagles Charitable FoundationEIN 23-2794290 | Human Services | PA | $1,448,292Small | 84.23 |
| East Bay Alliance for A Sustainable EconomyEIN 94-3314108 | Human Services | CA | $1,290,909Small | 91.25 |
| East Cooper Community OutreachEIN 57-0939280 | Human Services | SC | $1,871,995Small | 97.17 |
| East End HouseEIN 04-2104163 | Human Services | MA | $2,610,655Small | 80.06 |
| East Side HouseEIN 13-1623989 | Human Services | NY | $22,000,963Large | 98.23 |
| East Texas Crisis CenterEIN 75-1641173 | Human Services | TX | $2,141,385Small | 86.52 |
| East Texas Food BankEIN 75-2222686 | Human Services | TX | $32,138,551Large | 95.28 |
| Easter Seals Capper FoundationEIN 48-0543745 | Human Services | KS | $13,693,269Large | 92.92 |
| Eastern Illinois FoodbankEIN 37-1130252 | Human Services | IL | $19,826,056Large | 95.05 |
| Eastside Baby CornerEIN 91-1617032 | Human Services | WA | $7,561,571Mid-sized | 88.14 |
| Eastside Community MinistryEIN 31-0952074 | Human Services | OH | $698,117Small | 67.57 |
| Ebenezer Christian Children's HomeEIN 56-1861709 | Human Services | NC | $2,295,078Small | 82.89 |
| ECHO (Everyone Cooperating to Help Others)EIN 39-1222279 | Human Services | WI | $2,388,786Small | 92.59 |
| ECHO of BrandonEIN 59-3051533 | Human Services | FL | $1,536,158Small | 78.95 |
| Ecumenical Hunger ProgramEIN 94-2476942 | Human Services | CA | $5,283,069Mid-sized | 98.23 |
| Edgar Cayce's A.R.E.EIN 54-0573802 | Human Services | VA | $7,633,709Mid-sized | 86.67 |
| Edgewood Children's RanchEIN 59-1150182 | Human Services | FL | $1,868,366Small | 93.28 |
| Edith and Carl Marks Jewish Community House of BensonhurstEIN 11-1633484 | Human Services | NY | $9,407,466Mid-sized | 91.97 |
| EFRAT-C.R.I.B. Committee for the Rescue of Israel's BabiesEIN 22-3431457 | Human Services | NY | $2,588,353Small | 86.13 |
| El Buen SamaritanoEIN 74-2488682 | Human Services | TX | $6,467,481Mid-sized | 92.31 |
| ElderHelp of San DiegoEIN 95-2880426 | Human Services | CA | $1,169,210Small | 92.85 |
| Ele's PlaceEIN 38-2976751 | Human Services | MI | $2,794,372Small | 87.66 |
| ELEM/Youth in Distress in IsraelEIN 13-3171815 | Human Services | NY | $888,375Small | 74.55 |
| Elijah's PromiseEIN 22-3055539 | Human Services | NJ | $2,160,208Small | 89.02 |
| Elk Grove Food Bank ServicesEIN 38-3664737 | Human Services | CA | $2,664,368Small | 83.01 |
| ElunaEIN 91-2065051 | Human Services | PA | $2,819,395Small | 91.13 |
| Emerald Coast Children's Advocacy CenterEIN 59-3454168 | Human Services | FL | $1,242,926Small | 90.70 |
| Emerald Youth FoundationEIN 62-1474791 | Human Services | TN | $4,181,968Mid-sized | 90.73 |
| Emergency Family Assistance AssociationEIN 84-0454115 | Human Services | CO | $4,325,753Mid-sized | 88.34 |
| Emergency Food NetworkEIN 94-3131776 | Human Services | WA | $23,422,846Large | 91.78 |
| Emergency Infant ServicesEIN 73-1039524 | Human Services | OK | $3,126,481Small | 95.47 |
| Emily K CenterEIN 56-2230469 | Human Services | NC | $2,219,274Small | 91.11 |
| Emunah of AmericaEIN 13-2670365 | Human Services | NY | $5,123,297Mid-sized | 82.55 |
| EncompassEIN 91-0825232 | Human Services | WA | $3,883,177Mid-sized | 89.50 |
| Energy Outreach ColoradoEIN 74-2543881 | Human Services | CO | $25,022,578Large | 90.82 |
| Environmental Traveling CompanionsEIN 51-0158789 | Human Services | CA | $1,111,244Small | 78.76 |
| EOD Warrior FoundationEIN 20-8618412 | Human Services | FL | $1,378,932Small | 92.02 |
| Episcopal Charities of the Diocese of New YorkEIN 13-3902908 | Human Services | NY | $1,785,346Small | 86.42 |
| Epworth Children's HomeEIN 57-0314389 | Human Services | SC | $6,948,186Mid-sized | 94.72 |