| Abraham Lincoln Presidential Library FoundationEIN 36-4385644 | Arts, Culture, Humanities | IL | $2,790,813Small | 74.05 |
| Academy of Nutrition and Dietetics FoundationEIN 36-6150906 | Health | IL | $3,393,217Small | 90.16 |
| Action for Healthy KidsEIN 47-0902020 | Human Services | IL | $6,287,691Mid-sized | 95.47 |
| Adler PlanetariumEIN 36-6210902 | Arts, Culture, Humanities | IL | $18,818,691Large | 84.58 |
| Administer JusticeEIN 36-4348917 | Human and Civil Rights | IL | $1,668,776Small | 86.67 |
| Advance IllinoisEIN 26-2052733 | Education | IL | $2,382,775Small | 87.10 |
| Al-Furqaan FoundationEIN 20-0310701 | Religion | IL | $2,207,498Small | 76.84 |
| All God's ChildrenEIN 38-2992649 | International | IL | $1,413,690Small | 96.46 |
| Alliance For The Great LakesEIN 23-7104524 | Environment | IL | $3,549,306Mid-sized | 97.72 |
| Alpha USAEIN 13-3962840 | Religion | IL | $8,024,235Mid-sized | 77.72 |
| AlternativesEIN 36-2720602 | Human Services | IL | $3,464,767Small | 83.96 |
| Alzheimer's AssociationEIN 13-3039601 | Health | IL | $359,577,467Large | 88.70 |
| American Bar Association Fund for Justice and EducationEIN 36-6110299 | Human and Civil Rights | IL | $74,100,402Large | 82.08 |
| American Brain Tumor AssociationEIN 23-7286648 | Health | IL | $5,638,221Mid-sized | 89.86 |
| American Foundation for Surgery of the HandEIN 74-2428242 | Health | IL | $1,663,447Small | 90.87 |
| American Lung Association, National HeadquartersEIN 13-1632524 | Health | IL | $39,339,462Large | 83.94 |
| American Medical Association FoundationEIN 36-6080517 | Health | IL | $2,759,140Small | 68.05 |
| American Veterinary Medical FoundationEIN 36-6117739 | Animals | IL | $2,053,777Small | 92.38 |
| Anderson Animal ShelterEIN 36-6164626 | Animals | IL | $2,677,397Small | 94.45 |
| Angelman Syndrome FoundationEIN 59-3092842 | Health | IL | $2,446,564Small | 90.57 |
| Animal Welfare LeagueEIN 36-2235155 | Animals | IL | $6,855,668Mid-sized | 91.39 |
| AwanaEIN 36-2428692 | Religion | IL | $31,541,865Large | 81.37 |
| Barnabas FoundationEIN 36-2904503 | Community Development | IL | $67,443,319Large | 91.36 |
| Bear Necessities Pediatric Cancer FoundationEIN 36-3874655 | Health | IL | $1,914,328Small | 81.66 |
| Better Government AssociationEIN 36-0802950 | Human and Civil Rights | IL | $3,079,240Small | 96.89 |
| Big Brothers Big Sisters of Metropolitan ChicagoEIN 36-2681212 | Human Services | IL | $4,638,926Mid-sized | 90.64 |
| Big Shoulders FundEIN 36-3490557 | Education | IL | $18,807,655Large | 98.64 |
| Boy Scouts of America, Blackhawk Area CouncilEIN 36-2169127 | Human Services | IL | $2,304,214Small | 82.08 |
| Boys & Girls Clubs of ChicagoEIN 36-2166997 | Human Services | IL | $11,614,203Mid-sized | 82.66 |
| Brain Research FoundationEIN 36-2477928 | Health | IL | $2,056,920Small | 91.34 |
| BreakthroughEIN 36-3810926 | Human Services | IL | $6,843,784Mid-sized | 96.46 |
| Bridge CommunitiesEIN 36-3705951 | Human Services | IL | $3,537,590Mid-sized | 91.44 |
| Bright Hope InternationalEIN 23-7004991 | Religion | IL | $5,613,402Mid-sized | 85.85 |
| Bright PinkEIN 51-0619889 | Health | IL | $2,689,062Small | 84.42 |
| Brighton Park Neighborhood CouncilEIN 36-4229387 | Community Development | IL | $3,677,373Mid-sized | 90.58 |
| BUILD, Inc.EIN 23-7022085 | Human Services | IL | $2,698,597Small | 93.96 |
| Cabrini-Green Legal AidEIN 36-2775706 | Human and Civil Rights | IL | $2,242,229Small | 83.56 |
| Call to ActionEIN 36-3003308 | Religion | IL | $386,558Small | 77.69 |
| Cancer Wellness CenterEIN 36-3604463 | Health | IL | $1,393,436Small | 98.70 |
| CareNet Pregnancy Services of DupageEIN 36-3154700 | Human Services | IL | $1,153,653Small | 76.13 |
| CARPLSEIN 36-3863573 | Human and Civil Rights | IL | $2,056,206Small | 90.17 |
| Center for Economic ProgressEIN 36-3693728 | Human Services | IL | $3,171,304Small | 77.27 |
| Center for Neighborhood TechnologyEIN 36-2967283 | Environment | IL | $4,290,326Mid-sized | 71.62 |
| Center on HalstedEIN 51-0178807 | Human and Civil Rights | IL | $6,293,773Mid-sized | 97.46 |
| Central Illinois FoodbankEIN 37-1106465 | Human Services | IL | $18,256,991Large | 92.92 |
| Champaign County Humane SocietyEIN 37-0714217 | Animals | IL | $1,058,761Small | 85.28 |
| CHEST FoundationEIN 36-3286520 | Health | IL | $1,575,560Small | 89.58 |
| Chicago Academy of Sciences / Peggy Notebaert Nature MuseumEIN 36-0895575 | Arts, Culture, Humanities | IL | $6,434,381Mid-sized | 87.59 |
| Chicago Arts Partnerships in EducationEIN 36-3969334 | Education | IL | $1,393,218Small | 81.00 |
| Chicago Bar FoundationEIN 36-6109584 | Human and Civil Rights | IL | $4,461,315Mid-sized | 88.90 |
| Chicago Botanic GardenEIN 36-2225482 | Environment | IL | $48,755,048Large | 88.85 |
| Chicago CaresEIN 36-3777709 | Community Development | IL | $3,287,575Small | 90.59 |
| Chicago Children's ChoirEIN 51-0140419 | Education | IL | $4,025,337Mid-sized | 82.63 |
| Chicago Children's MuseumEIN 36-3162484 | Arts, Culture, Humanities | IL | $7,043,221Mid-sized | 81.00 |
| Chicago Coalition for the HomelessEIN 36-3292607 | Human Services | IL | $2,898,914Small | 100.00 |
| Chicago Gateway GreenEIN 36-3764084 | Environment | IL | $618,570Small | 82.05 |
| Chicago History MuseumEIN 36-2167004 | Arts, Culture, Humanities | IL | $16,954,477Large | 77.98 |
| Chicago Hope AcademyEIN 36-4244054 | Education | IL | $4,257,955Mid-sized | 84.66 |
| Chicago Humanities FestivalEIN 36-7148236 | Arts, Culture, Humanities | IL | $3,736,155Mid-sized | 83.39 |
| Chicago Lawyers' Committee for Civil Rights Under LawEIN 51-0189264 | Human and Civil Rights | IL | $2,101,380Small | 86.04 |