| American Leprosy MissionsEIN 13-5562163 | International | SC | $14,437,414Large | 87.06 |
| Arts Partnership of Greater SpartanburgEIN 57-0986224 | Arts, Culture, Humanities | SC | $3,298,407Small | 87.41 |
| Boy Scouts of America Blue Ridge CouncilEIN 57-0314427 | Human Services | SC | $2,243,186Small | 85.14 |
| Boy Scouts of America, Coastal Carolina CouncilEIN 57-0327870 | Human Services | SC | $1,586,419Small | 82.65 |
| Boy Scouts of America, Indian Waters CouncilEIN 57-0314440 | Human Services | SC | $2,021,410Small | 84.88 |
| Boy Scouts of America, Palmetto CouncilEIN 57-0314450 | Human Services | SC | $1,379,214Small | 74.60 |
| Boys & Girls Clubs of the LowcountryEIN 57-0811876 | Human Services | SC | $3,202,737Small | 89.79 |
| Boys & Girls Clubs of the UpstateEIN 57-0862226 | Human Services | SC | $2,598,891Small | 86.84 |
| Center for Development ServicesEIN 57-0988275 | Human Services | SC | $1,406,021Small | 93.01 |
| Charleston Animal SocietyEIN 57-6021863 | Animals | SC | $7,048,049Mid-sized | 94.16 |
| Charleston Symphony OrchestraEIN 57-6000192 | Arts, Culture, Humanities | SC | $3,490,071Small | 89.02 |
| Charleston Wine + Food FestivalEIN 20-2671674 | Arts, Culture, Humanities | SC | $3,135,643Small | 85.49 |
| Chosen Children MinistriesEIN 62-1636128 | Religion | SC | $1,203,968Small | 91.04 |
| Christian Blind Mission InternationalEIN 36-2959883 | International | SC | $158,563,714Large | 90.00 |
| Coastal Conservation LeagueEIN 57-0887278 | Environment | SC | $3,691,863Mid-sized | 91.84 |
| Columbia Museum of ArtEIN 57-6007869 | Arts, Culture, Humanities | SC | $4,269,010Mid-sized | 78.98 |
| Communities in Schools of the Charleston AreaEIN 57-0915384 | Education | SC | $1,667,084Small | 85.38 |
| Connie Maxwell Children's HomeEIN 57-0324927 | Human Services | SC | $9,553,199Mid-sized | 87.85 |
| Dining for WomenEIN 20-0031928 | International | SC | $1,423,715Small | 88.01 |
| East Cooper Community OutreachEIN 57-0939280 | Human Services | SC | $1,871,995Small | 97.17 |
| EdVentureEIN 57-1013857 | Arts, Culture, Humanities | SC | $4,782,439Mid-sized | 86.39 |
| Epworth Children's HomeEIN 57-0314389 | Human Services | SC | $6,948,186Mid-sized | 94.72 |
| ETV Endowment of South CarolinaEIN 57-0657549 | Arts, Culture, Humanities | SC | $7,062,134Mid-sized | 96.42 |
| Gibbes Museum of ArtEIN 57-0323047 | Arts, Culture, Humanities | SC | $2,971,358Small | 77.90 |
| Greenville Free Medical ClinicEIN 57-0855205 | Health | SC | $11,135,907Mid-sized | 94.69 |
| Greenville Humane SocietyEIN 57-6000563 | Animals | SC | $3,403,750Small | 98.07 |
| Habitat for Humanity of Greenville CountyEIN 57-0827063 | Community Development | SC | $5,862,497Mid-sized | 91.20 |
| Habitat For Humanity of SpartanburgEIN 57-0849669 | Community Development | SC | $1,572,050Small | 98.23 |
| Harvest Hope Food BankEIN 57-0725560 | Human Services | SC | $54,380,852Large | 89.17 |
| Haven of Rest Ministries, Inc.EIN 57-0422667 | Human Services | SC | $3,129,307Small | 87.35 |
| Hilton Head Symphony OrchestraEIN 57-0761297 | Arts, Culture, Humanities | SC | $2,050,293Small | 78.67 |
| Historic ColumbiaEIN 57-6020250 | Arts, Culture, Humanities | SC | $3,349,036Small | 91.45 |
| International Primate Protection LeagueEIN 51-0194013 | Animals | SC | $1,096,700Small | 97.24 |
| Lowcountry Food BankEIN 57-0751835 | Human Services | SC | $51,794,129Large | 90.42 |
| Lutheran Homes of South Carolina FoundationEIN 57-0342978 | Human Services | SC | $2,029,254Small | 91.16 |
| Make-A-Wish Foundation of South CarolinaEIN 57-0786119 | Health | SC | $3,589,748Mid-sized | 78.99 |
| Meals on Wheels of GreenvilleEIN 57-0531378 | Human Services | SC | $1,871,108Small | 84.92 |
| MetanoiaEIN 20-0310400 | Community Development | SC | $1,704,253Small | 94.07 |
| Meyer Center for Special ChildrenEIN 57-0361503 | Human Services | SC | $3,157,517Small | 76.42 |
| Middle Tyger Community CenterEIN 57-1077940 | Human Services | SC | $1,068,622Small | 85.81 |
| Miracle Hill MinistriesEIN 57-0425826 | Human Services | SC | $17,579,619Large | 89.75 |
| Mobile Meal Service of Spartanburg CountyEIN 57-0653452 | Human Services | SC | $2,170,786Small | 92.07 |
| National Wild Turkey FederationEIN 57-0564993 | Animals | SC | $41,988,609Large | 89.70 |
| Oliver Gospel MissionEIN 57-6027750 | Human Services | SC | $3,388,839Small | 88.44 |
| Pendleton PlaceEIN 57-0624421 | Human Services | SC | $1,934,596Small | 93.60 |
| Pet HelpersEIN 57-0802283 | Animals | SC | $1,695,746Small | 73.66 |
| Radio Training NetworkEIN 58-1585542 | Religion | SC | $18,872,250Large | 68.18 |
| Ronald McDonald House Charities of CharlestonEIN 57-0724845 | Health | SC | $1,595,982Small | 91.89 |
| South Carolina Governor's School for Science and Math FoundationEIN 57-0881347 | Education | SC | $2,340,649Small | 86.43 |
| South Carolina Woman's Missionary UnionEIN 57-0362065 | Religion | SC | $2,531,177Small | 79.42 |
| Southeastern Children's HomeEIN 23-7061916 | Human Services | SC | $1,045,679Small | 89.15 |
| Spartanburg Humane SocietyEIN 57-0481019 | Animals | SC | $1,598,762Small | 81.52 |
| Special Olympics South CarolinaEIN 57-0680248 | Human Services | SC | $2,816,864Small | 91.89 |
| Spoleto Festival USAEIN 57-0660848 | Arts, Culture, Humanities | SC | $8,737,036Mid-sized | 82.85 |
| Tamassee DAR SchoolEIN 57-6000973 | Human Services | SC | $3,358,215Small | 91.85 |
| Tara HallEIN 23-7111696 | Human Services | SC | $1,175,001Small | 82.58 |
| The Dictionary ProjectEIN 57-1029802 | Education | SC | $4,276,550Mid-sized | 75.68 |
| The South Carolina Historical SocietyEIN 57-0323800 | Arts, Culture, Humanities | SC | $950,748Small | 84.84 |
| Thornwell Home for ChildrenEIN 57-0314418 | Human Services | SC | $9,386,658Mid-sized | 96.11 |
| Transitions Homeless Recovery CenterEIN 20-3524141 | Human Services | SC | $2,600,403Small | 92.65 |