| The Children's Theatre of CincinnatiEIN 31-6026285 | Arts, Culture, Humanities | OH | $3,697,998Mid-sized | 82.83 |
| The Christian Broadcasting NetworkEIN 54-0678752 | Religion | VA | $319,708,060Large | 88.20 |
| The Christmas Box InternationalEIN 31-1617816 | Human Services | UT | $1,432,198Small | 85.19 |
| The ChristophersEIN 13-1809274 | Religion | NY | $1,565,431Small | 88.06 |
| The Claremont InstituteEIN 95-3443202 | Research and Public Policy | CA | $5,093,063Mid-sized | 83.87 |
| The Cleveland Museum of ArtEIN 34-0714336 | Arts, Culture, Humanities | OH | $60,688,211Large | 88.50 |
| The Cleveland OrchestraEIN 34-0714468 | Arts, Culture, Humanities | OH | $55,320,592Large | 81.92 |
| The Cleveland Play HouseEIN 34-6515260 | Arts, Culture, Humanities | OH | $9,758,556Mid-sized | 88.22 |
| The Climate Reality ProjectEIN 87-0745629 | Environment | DC | $16,685,214Large | 88.37 |
| The College Crusade of Rhode IslandEIN 22-3031765 | Education | RI | $5,119,803Mid-sized | 89.11 |
| The Colorado Center for the BlindEIN 74-2465141 | Human Services | CO | $2,780,286Small | 89.31 |
| The Columbus MuseumEIN 58-6042894 | Arts, Culture, Humanities | GA | $3,185,682Small | 86.64 |
| The Committee for Hispanic Children and FamiliesEIN 11-2622003 | Human Services | NY | $4,491,509Mid-sized | 85.43 |
| The ConcilioEIN 75-1770140 | Human Services | TX | $1,787,285Small | 84.62 |
| The Connecticut ForumEIN 06-1343149 | Education | CT | $1,445,906Small | 80.07 |
| The Conservation AllianceEIN 94-3100867 | Environment | OR | $2,283,620Small | 87.20 |
| The Contemporary AustinEIN 74-1233816 | Arts, Culture, Humanities | TX | $6,467,043Mid-sized | 86.08 |
| The Council of State GovernmentsEIN 36-6000818 | Research and Public Policy | KY | $39,651,190Large | 80.51 |
| The CradleEIN 36-2181994 | Human Services | IL | $6,967,977Mid-sized | 80.76 |
| The Crisis Center of Johnson CountyEIN 42-0955992 | Human Services | IA | $3,857,253Mid-sized | 89.24 |
| The Crystal Charity BallEIN 75-6035893 | Human Services | TX | $6,021,474Mid-sized | 86.56 |
| The Cummer Museum of Art & GardensEIN 59-2191587 | Arts, Culture, Humanities | FL | $4,800,748Mid-sized | 86.34 |
| The Dayton FoundationEIN 31-6027287 | Community Development | OH | $27,126,725Large | 83.65 |
| The Delaware Symphony OrchestraEIN 51-6017449 | Arts, Culture, Humanities | DE | $1,645,578Small | 87.75 |
| The Detroit Institute for ChildrenEIN 38-1359511 | Human Services | MI | $2,624,067Small | 85.57 |
| The Detroit Institute of ArtsEIN 38-1359510 | Arts, Culture, Humanities | MI | $40,056,968Large | 89.52 |
| The Dixon Gallery and GardensEIN 62-0943809 | Arts, Culture, Humanities | TN | $5,237,638Mid-sized | 84.04 |
| The Dougy CenterEIN 93-0833241 | Human Services | OR | $1,868,201Small | 85.69 |
| The Drawing CenterEIN 13-2887872 | Arts, Culture, Humanities | NY | $2,272,751Small | 81.16 |
| The Dream CorpsEIN 26-1140201 | Human and Civil Rights | CA | $5,326,354Mid-sized | 81.07 |
| The Edible Schoolyard ProjectEIN 94-3248671 | Education | CA | $2,100,818Small | 84.93 |
| The Education FundEIN 59-2468114 | Education | FL | $2,612,408Small | 86.44 |
| The Elaine Clark CenterEIN 58-1079411 | Human Services | GA | $948,317Small | 82.10 |
| The Empty Stocking FundEIN 23-7159125 | Human Services | GA | $1,124,541Small | 87.70 |
| The Exchange Club Family Center of the Mid-SouthEIN 58-1502697 | Human Services | TN | $2,181,701Small | 82.00 |
| The Explorers ClubEIN 13-1866795 | Arts, Culture, Humanities | NY | $2,454,020Small | 82.53 |
| The Fabric Workshop and MuseumEIN 23-2018929 | Arts, Culture, Humanities | PA | $2,737,279Small | 83.91 |
| The Family CenterEIN 58-0828094 | Human Services | GA | $1,239,064Small | 85.38 |
| The Family ConservancyEIN 44-0454800 | Human Services | KS | $13,903,035Large | 87.04 |
| The Family Pantry of Cape CodEIN 22-3079904 | Human Services | MA | $2,601,689Small | 81.58 |
| The Farm SchoolEIN 22-2959081 | Education | MA | $1,772,558Small | 86.10 |
| The Federation, Jewish Communities of Western ConnecticutEIN 06-0646691 | Community Development | CT | $1,014,890Small | 85.85 |
| The FieldEIN 13-3357408 | Arts, Culture, Humanities | NY | $2,808,891Small | 85.85 |
| The Filson Historical SocietyEIN 61-0444690 | Arts, Culture, Humanities | KY | $2,690,373Small | 84.18 |
| The First Tee Metropolitan New YorkEIN 31-1724122 | Human Services | NY | $3,938,992Mid-sized | 82.96 |
| The Flea TheaterEIN 13-3904262 | Arts, Culture, Humanities | NY | $1,692,384Small | 86.38 |
| The Florence ProjectEIN 86-0658103 | Human and Civil Rights | AZ | $4,451,296Mid-sized | 89.16 |
| The Florida OrchestraEIN 59-1223691 | Arts, Culture, Humanities | FL | $10,882,617Mid-sized | 89.92 |
| The Food Bank for Central & Northeast MissouriEIN 43-1238934 | Human Services | MO | $58,016,683Large | 89.63 |
| The Food Bank of Lower Fairfield CountyEIN 02-0684220 | Human Services | CT | $3,103,405Small | 89.39 |
| The Food GroupEIN 41-1246504 | Human Services | MN | $10,589,042Mid-sized | 89.99 |
| The Food ProjectEIN 04-3262532 | Human Services | MA | $3,145,679Small | 85.39 |
| The Foundry MinistriesEIN 63-0624278 | Health | AL | $7,931,129Mid-sized | 87.63 |
| The Francis Ouimet Scholarship FundEIN 04-2234126 | Education | MA | $3,325,480Small | 89.54 |
| The Free Clinic of Central VirginiaEIN 54-1420756 | Health | VA | $2,747,473Small | 83.24 |
| The Fresh Air FundEIN 13-1656653 | Human Services | NY | $19,122,855Large | 83.47 |
| The Friends of the Saint Paul Public LibraryEIN 41-6029683 | Arts, Culture, Humanities | MN | $2,988,742Small | 80.59 |
| The Fuller Center for HousingEIN 52-2455871 | Community Development | GA | $2,916,183Small | 89.86 |
| The Fund for American StudiesEIN 13-6223604 | Education | DC | $11,334,174Mid-sized | 88.55 |
| The Fund for Global Human RightsEIN 75-3029336 | International | DC | $13,234,748Mid-sized | 89.07 |