| Idaho Conservation LeagueEIN 82-6042478 | Environment | ID | $1,970,384Small | 91.68 |
| IHCF African Christian HospitalsEIN 23-7258102 | International | AR | $972,858Small | 85.39 |
| Illinois Network of Charter SchoolsEIN 14-1862409 | Education | IL | $2,793,417Small | 90.60 |
| Illinois Valley Public Telecommunications CorporationEIN 23-7041401 | Arts, Culture, Humanities | IL | $3,110,167Small | 76.51 |
| Imagine America FoundationEIN 52-1250860 | Education | VA | $782,154Small | 67.82 |
| Imagine Children's MuseumEIN 94-3153591 | Arts, Culture, Humanities | WA | $2,018,647Small | 96.07 |
| Immigrant Law Center of MinnesotaEIN 41-0909036 | Human and Civil Rights | MN | $2,052,064Small | 95.32 |
| Immokalee Child Care CenterEIN 59-1209842 | Human Services | FL | $1,322,503Small | 91.40 |
| Immunization Action CoalitionEIN 41-1768237 | Health | MN | $2,652,751Small | 78.71 |
| Impression 5 Science CenterEIN 23-7200548 | Arts, Culture, Humanities | MI | $1,619,983Small | 90.58 |
| In Touch Mission InternationalEIN 94-2783852 | Religion | AZ | $1,372,833Small | 85.04 |
| INCLUDEnycEIN 11-2594790 | Human Services | NY | $2,915,236Small | 92.80 |
| Independence InstituteEIN 84-0990300 | Research and Public Policy | CO | $2,907,995Small | 91.15 |
| Independence MediaEIN 22-2600747 | Arts, Culture, Humanities | PA | $2,758,153Small | 87.44 |
| Independent Catholic Foundation for the Diocese of Altoona-JohnstownEIN 25-1625390 | Religion | PA | $1,123,592Small | 96.69 |
| Independent Media InstituteEIN 52-1309876 | Arts, Culture, Humanities | NY | $2,023,149Small | 77.38 |
| India Development and Relief Fund, Inc. (IDRF)EIN 52-1555563 | International | MD | $1,974,078Small | 98.23 |
| India Gospel OutreachEIN 33-0193797 | Religion | CA | $1,339,644Small | 85.94 |
| Indian Law Resource CenterEIN 52-1121079 | Human and Civil Rights | MT | $1,268,568Small | 92.29 |
| Indianapolis Opera CompanyEIN 35-1405179 | Arts, Culture, Humanities | IN | $1,109,270Small | 68.68 |
| Indianapolis Urban LeagueEIN 35-6060655 | Human and Civil Rights | IN | $2,226,625Small | 84.04 |
| Infant Crisis ServicesEIN 73-1378766 | Human Services | OK | $3,345,296Small | 92.89 |
| Initiative for Global DevelopmentEIN 20-8003146 | International | DC | $1,036,574Small | 74.91 |
| INSIGHTEIN 05-0272278 | Human Services | RI | $848,297Small | 94.37 |
| Inspire WomenEIN 35-2203762 | Education | TX | $1,006,348Small | 79.22 |
| Institute for Agriculture and Trade PolicyEIN 36-3501938 | Research and Public Policy | MN | $1,790,307Small | 83.92 |
| Institute for America's FutureEIN 52-1971942 | Research and Public Policy | DC | $2,915,846Small | 83.56 |
| Institute for American ValuesEIN 13-3400377 | Research and Public Policy | NY | $626,271Small | 62.30 |
| Institute for Educational AdvancementEIN 95-4695698 | Education | CA | $2,150,889Small | 89.48 |
| Institute for Energy ResearchEIN 76-0149778 | Research and Public Policy | DC | $1,666,571Small | 89.48 |
| Institute for Foreign Policy AnalysisEIN 51-0192436 | International | MA | $935,517Small | 63.22 |
| Institute for Free SpeechEIN 20-3676886 | Human and Civil Rights | VA | $1,939,035Small | 97.23 |
| Institute for Global EngagementEIN 23-3042456 | International | VA | $1,479,806Small | 85.85 |
| Institute for Local Self-RelianceEIN 23-7394104 | Research and Public Policy | DC | $1,525,548Small | 91.75 |
| Institute for Middle East UnderstandingEIN 20-2389388 | International | CA | $1,491,358Small | 85.79 |
| Institute for the Analysis of Global SecurityEIN 22-3880419 | International | MD | $884,482Small | 60.29 |
| Institute for the Study of WarEIN 26-0273675 | Research and Public Policy | DC | $1,843,667Small | 81.77 |
| Institute for Women's Policy ResearchEIN 52-1549572 | Research and Public Policy | DC | $3,176,103Small | 86.79 |
| Institute of Contemporary Art, Los AngelesEIN 95-3992968 | Arts, Culture, Humanities | CA | $1,286,254Small | 77.28 |
| Institute of Southern Jewish LifeEIN 64-0762027 | Religion | MS | $2,606,555Small | 75.31 |
| Institute on Religion and Public LifeEIN 52-1628303 | Research and Public Policy | NY | $2,861,837Small | 70.49 |
| Institute on Taxation and Economic PolicyEIN 04-2688165 | Research and Public Policy | DC | $1,804,899Small | 93.91 |
| Inter-Faith Council for Social ServiceEIN 59-1224041 | Human Services | NC | $2,451,180Small | 90.92 |
| InterActEIN 58-1320613 | Human Services | NC | $3,155,277Small | 89.26 |
| InterAct MinistriesEIN 92-6004561 | Religion | OR | $2,315,997Small | 84.18 |
| Interface MinistriesEIN 58-1970866 | Religion | GA | $1,206,568Small | 86.94 |
| Interfaith Assistance MinistryEIN 58-1556963 | Human Services | NC | $1,014,698Small | 87.89 |
| Interfaith Caring MinistriesEIN 76-0143694 | Human Services | TX | $1,230,577Small | 83.85 |
| Interfaith Community Housing of DelawareEIN 51-0298556 | Community Development | DE | $1,820,586Small | 86.24 |
| Interfaith Dental ClinicEIN 62-1567615 | Health | TN | $3,178,785Small | 83.70 |
| Interfaith Education FundEIN 74-2548241 | Education | TX | $1,714,577Small | 81.01 |
| Interfaith Emergency ServicesEIN 59-2349840 | Human Services | FL | $3,483,782Small | 67.98 |
| Interfaith Family ServicesEIN 75-2028254 | Human Services | TX | $1,743,817Small | 90.51 |
| InterFaith Health ClinicEIN 58-1947641 | Health | TN | $2,717,785Small | 88.10 |
| Interfaith Power & LightEIN 94-3335236 | Environment | CA | $1,481,890Small | 82.03 |
| Interfaith Social ServicesEIN 04-2104853 | Human Services | MA | $1,687,636Small | 89.02 |
| Interfaith Worker JusticeEIN 36-4063982 | Human and Civil Rights | IL | $1,531,688Small | 77.46 |
| InterfaithFamilyEIN 04-3577816 | Religion | MA | $2,977,372Small | 83.71 |
| International Board of Jewish MissionsEIN 58-0669998 | Religion | TN | $3,187,830Small | 75.19 |
| International Campaign for TibetEIN 52-1570071 | International | DC | $3,169,181Small | 87.16 |