| SFJAZZEIN 94-2990335 | Arts, Culture, Humanities | CA | $16,924,582Large | 84.54 |
| Shane's InspirationEIN 95-4760497 | Human Services | CA | $2,205,495Small | 83.43 |
| ShantiEIN 94-2297147 | Health | CA | $4,966,512Mid-sized | 86.47 |
| Share Our SelvesEIN 95-3222316 | Human Services | CA | $17,655,264Large | 90.63 |
| Shelter PartnershipEIN 95-3976214 | Human Services | CA | $11,932,800Mid-sized | 93.29 |
| Shepherd's GateEIN 94-2902803 | Human Services | CA | $5,006,170Mid-sized | 88.98 |
| Sheriff's Youth Foundation of Los Angeles CountyEIN 95-4047797 | Human Services | CA | $1,407,444Small | 87.30 |
| Shoes That FitEIN 95-4425565 | Human Services | CA | $5,130,693Mid-sized | 94.69 |
| Sierra Club FoundationEIN 94-6069890 | Environment | CA | $72,890,348Large | 95.21 |
| Sierra Nevada AllianceEIN 77-0343881 | Environment | CA | $825,345Small | 79.38 |
| Silicon Valley CreatesEIN 94-2825213 | Arts, Culture, Humanities | CA | $2,479,545Small | 88.98 |
| Silicon Valley Education FoundationEIN 20-5061316 | Education | CA | $5,764,125Mid-sized | 86.21 |
| Skid Row Housing TrustEIN 95-4205316 | Community Development | CA | $21,003,687Large | 81.70 |
| Skirball Cultural CenterEIN 95-4538371 | Arts, Culture, Humanities | CA | $25,294,003Large | 87.83 |
| Smuin BalletEIN 94-3197247 | Arts, Culture, Humanities | CA | $4,135,237Mid-sized | 88.33 |
| Society of St. Vincent de Paul of Alameda CountyEIN 94-1156493 | Human Services | CA | $5,959,918Mid-sized | 84.57 |
| Society of St. Vincent de Paul of San Mateo CountyEIN 94-1375833 | Human Services | CA | $6,229,067Mid-sized | 87.77 |
| Soil Born Farms Urban Agriculture & Education ProjectEIN 20-0774693 | Education | CA | $1,888,739Small | 79.87 |
| Solar Cookers InternationalEIN 68-0153141 | Environment | CA | $773,030Small | 91.37 |
| Solutions for ChangeEIN 33-0902617 | Human Services | CA | $3,329,200Small | 79.52 |
| Solve ME/CFS InitiativeEIN 56-1683450 | Health | CA | $1,925,767Small | 88.69 |
| Sonoma Valley Education FoundationEIN 68-0279152 | Education | CA | $1,722,094Small | 81.79 |
| South Coast RepertoryEIN 95-6122708 | Arts, Culture, Humanities | CA | $11,651,004Mid-sized | 86.11 |
| Southern California Public RadioEIN 95-4765734 | Arts, Culture, Humanities | CA | $27,593,781Large | 85.94 |
| spcaLAEIN 95-1738153 | Animals | CA | $7,647,760Mid-sized | 85.75 |
| Special Olympics Southern CaliforniaEIN 95-4538450 | Human Services | CA | $11,029,255Mid-sized | 97.23 |
| Spondylitis Association of AmericaEIN 95-3890767 | Health | CA | $1,301,054Small | 91.90 |
| SPUREIN 94-1498232 | Research and Public Policy | CA | $6,462,777Mid-sized | 88.07 |
| St. Anne'sEIN 95-1691306 | Human Services | CA | $25,417,077Large | 93.91 |
| St. Baldrick's FoundationEIN 20-1173824 | Health | CA | $41,680,500Large | 77.72 |
| St. Francis CenterEIN 95-4479271 | Human Services | CA | $3,444,965Small | 87.34 |
| St. Joseph CenterEIN 95-3874381 | Human Services | CA | $15,753,740Large | 91.58 |
| St. Mary's CenterEIN 68-0172229 | Human Services | CA | $3,039,558Small | 96.66 |
| St. Mary's Dining RoomEIN 94-2687280 | Human Services | CA | $2,522,317Small | 87.86 |
| St. Vincent de Paul Society of Marin CountyEIN 94-1207701 | Human Services | CA | $4,107,059Mid-sized | 96.42 |
| St. Vincent de Paul VillageEIN 33-0492302 | Human Services | CA | $31,913,973Large | 81.26 |
| St. Vincent Meals on WheelsEIN 95-3696693 | Human Services | CA | $8,085,613Mid-sized | 86.11 |
| Stand.earthEIN 94-3331587 | Environment | CA | $3,081,289Small | 88.89 |
| StandWithUsEIN 01-0566033 | International | CA | $12,583,673Mid-sized | 95.47 |
| Starlight Children's FoundationEIN 95-3802159 | Health | CA | $9,806,057Mid-sized | 93.94 |
| State Street BalletEIN 86-0717486 | Arts, Culture, Humanities | CA | $1,295,799Small | 80.63 |
| Step UpEIN 95-4701468 | Human Services | CA | $4,222,065Mid-sized | 95.14 |
| Stern Grove Festival AssociationEIN 94-6064356 | Arts, Culture, Humanities | CA | $2,645,452Small | 80.95 |
| Storyteller Children's CenterEIN 77-0283072 | Human Services | CA | $1,611,343Small | 91.38 |
| Students InternationalEIN 77-0410440 | Religion | CA | $4,549,657Mid-sized | 88.40 |
| Students Rising AboveEIN 81-0615887 | Education | CA | $4,271,682Mid-sized | 90.42 |
| Students Run LAEIN 95-4430502 | Human Services | CA | $2,637,828Small | 97.10 |
| Summer SearchEIN 68-0200138 | Education | CA | $18,984,959Large | 79.19 |
| Sundance InstituteEIN 87-0361394 | Arts, Culture, Humanities | CA | $42,985,822Large | 88.22 |
| Sunnyvale Community ServicesEIN 94-1713897 | Human Services | CA | $7,426,109Mid-sized | 95.10 |
| Support Circle Pregnancy ClinicsEIN 94-2937281 | Health | CA | $1,470,007Small | 76.06 |
| Support The Enlisted Project (STEP)EIN 20-3051279 | Human Services | CA | $1,681,670Small | 94.41 |
| Sustainable ConservationEIN 94-3232437 | Environment | CA | $5,612,199Mid-sized | 88.59 |
| Symphony Silicon ValleyEIN 32-0083030 | Arts, Culture, Humanities | CA | $3,744,844Mid-sized | 83.56 |
| Taco Bell FoundationEIN 33-0523542 | Education | CA | $9,729,593Mid-sized | 91.14 |
| Taking Control of Your DiabetesEIN 33-0794608 | Health | CA | $4,188,227Mid-sized | 91.45 |
| Taproot FoundationEIN 91-2162645 | Human and Civil Rights | CA | $4,241,464Mid-sized | 76.63 |
| Tariq Khamisa FoundationEIN 33-0688465 | Human Services | CA | $381,431Small | 71.25 |
| Taylor Family FoundationEIN 94-3262932 | Health | CA | $1,783,479Small | 91.02 |
| Team RubiconEIN 27-1720480 | International | CA | $11,426,753Mid-sized | 91.42 |