| Mission EurasiaEIN 35-1835273 | Religion | IL | $4,262,417Mid-sized | 86.84 |
| Mission YearEIN 23-3005514 | Religion | IL | $735,526Small | 74.05 |
| MorningStar Mission MinistriesEIN 36-2422510 | Human Services | IL | $6,723,363Mid-sized | 89.50 |
| MPN Research FoundationEIN 36-4330967 | Health | IL | $1,929,928Small | 89.03 |
| Mujeres Latinas en AcciónEIN 36-2877520 | Human Services | IL | $3,109,740Small | 86.87 |
| Museum of Contemporary Art, ChicagoEIN 36-6154098 | Arts, Culture, Humanities | IL | $21,058,376Large | 87.71 |
| Museum of Science and Industry, ChicagoEIN 36-2167797 | Arts, Culture, Humanities | IL | $64,390,473Large | 85.34 |
| National Anti-Vivisection SocietyEIN 36-2229588 | Animals | IL | $2,699,620Small | 88.55 |
| National Association of Charter School AuthorizersEIN 84-1553195 | Education | IL | $6,522,654Mid-sized | 85.00 |
| National Council of YMCAs of the USAEIN 36-3258696 | Human Services | IL | $136,856,789Large | 94.57 |
| National Headache FoundationEIN 23-7073022 | Health | IL | $1,347,010Small | 85.59 |
| National Kidney Foundation of IllinoisEIN 36-6009226 | Health | IL | $1,622,137Small | 91.20 |
| National Museum of Mexican ArtEIN 36-3225519 | Arts, Culture, Humanities | IL | $4,173,128Mid-sized | 83.92 |
| National People's ActionEIN 36-2755109 | Human and Civil Rights | IL | $10,744,239Mid-sized | 89.85 |
| Neighborhood Housing Services of ChicagoEIN 23-7443009 | Community Development | IL | $4,208,251Mid-sized | 67.53 |
| Network KnowledgeEIN 37-1019920 | Arts, Culture, Humanities | IL | $2,662,550Small | 76.46 |
| New MomsEIN 36-3265804 | Human Services | IL | $3,112,344Small | 92.24 |
| Northern Illinois Food BankEIN 36-3203648 | Human Services | IL | $131,976,826Large | 91.81 |
| NPH USAEIN 65-1229309 | Human Services | IL | $18,458,495Large | 87.23 |
| One Acre FundEIN 20-3668110 | International | IL | $98,006,834Large | 90.19 |
| One CollectiveEIN 36-6069820 | Religion | IL | $11,173,031Mid-sized | 83.24 |
| One Million DegreesEIN 42-1710230 | Education | IL | $2,667,285Small | 87.16 |
| OneGoalEIN 56-2369898 | Education | IL | $11,929,410Mid-sized | 85.76 |
| Open BooksEIN 20-4830666 | Education | IL | $2,045,810Small | 84.17 |
| Orthopaedic Research and Education FoundationEIN 36-6009467 | Health | IL | $5,165,708Mid-sized | 69.21 |
| Ounce of Prevention FundEIN 36-3186328 | Human Services | IL | $56,161,326Large | 90.76 |
| PADS Lake CountyEIN 36-2948857 | Human Services | IL | $1,908,369Small | 89.02 |
| Pastoral Leadership InstituteEIN 43-1806114 | Religion | IL | $1,643,019Small | 69.72 |
| Pat Tillman FoundationEIN 20-1072336 | Human and Civil Rights | IL | $3,042,887Small | 90.27 |
| Pathways.orgEIN 52-2456469 | Health | IL | $3,272,387Small | 82.84 |
| PAWS ChicagoEIN 36-4219778 | Animals | IL | $9,630,561Mid-sized | 96.50 |
| People's Resource CenterEIN 36-3157600 | Human Services | IL | $9,360,167Mid-sized | 93.91 |
| Peoria Rescue MinistriesEIN 37-0804158 | Human Services | IL | $3,364,645Small | 92.60 |
| Planned Parenthood of IllinoisEIN 36-2170901 | Health | IL | $28,246,958Large | 88.94 |
| Prairie State Legal ServicesEIN 37-1030764 | Human and Civil Rights | IL | $11,009,442Mid-sized | 93.00 |
| Prevent BlindnessEIN 36-3667121 | Health | IL | $10,604,924Mid-sized | 89.68 |
| Prevent Child Abuse AmericaEIN 23-7235671 | Human Services | IL | $4,602,915Mid-sized | 96.30 |
| Pro-Life Action LeagueEIN 36-3081086 | Human and Civil Rights | IL | $929,376Small | 84.36 |
| Project AmaZonEIN 54-1383660 | Religion | IL | $3,359,487Small | 75.61 |
| Project ExplorationEIN 36-4305660 | Education | IL | $380,716Small | 77.15 |
| Pulmonary Fibrosis FoundationEIN 84-1558631 | Health | IL | $7,157,171Mid-sized | 84.51 |
| Ravinia FestivalEIN 36-6002273 | Arts, Culture, Humanities | IL | $42,396,239Large | 90.24 |
| Reading In MotionEIN 36-3235853 | Education | IL | $1,930,524Small | 82.87 |
| Resourcing Christian Education InternationalEIN 57-1154204 | Religion | IL | $6,823,625Mid-sized | 93.91 |
| Respiratory Health AssociationEIN 36-2222687 | Health | IL | $2,776,205Small | 81.10 |
| Restoration MinistriesEIN 36-3552070 | Human Services | IL | $2,526,753Small | 92.27 |
| ReVive Center for Housing and HealingEIN 36-2192804 | Human Services | IL | $2,298,503Small | 85.05 |
| Rock River Valley PantryEIN 36-3135643 | Human Services | IL | $1,583,827Small | 87.91 |
| Rockford Rescue MissionEIN 36-6132381 | Human Services | IL | $5,700,304Mid-sized | 90.10 |
| Roger Baldwin Foundation of ACLUEIN 36-2682569 | Human and Civil Rights | IL | $4,101,273Mid-sized | 92.22 |
| Ronald McDonald House CharitiesEIN 36-2934689 | Health | IL | $39,981,206Large | 92.82 |
| Ronald McDonald House Charities of Chicagoland and Northwest IndianaEIN 36-3532553 | Health | IL | $9,572,947Mid-sized | 85.23 |
| Roseland Christian MinistriesEIN 36-3094828 | Religion | IL | $956,307Small | 80.27 |
| Sarah's CircleEIN 36-3043662 | Human Services | IL | $2,023,629Small | 92.21 |
| Sargent Shriver National Center on Poverty LawEIN 36-3151279 | Human and Civil Rights | IL | $5,797,979Mid-sized | 92.18 |
| Save-A-Pet Adoption CenterEIN 23-7304570 | Animals | IL | $1,746,870Small | 91.33 |
| Sharing ConnectionsEIN 36-4363123 | Human Services | IL | $2,816,731Small | 90.62 |
| Shedd AquariumEIN 36-2167918 | Animals | IL | $59,336,621Large | 90.86 |
| Society of St. Vincent de Paul ChicagoEIN 36-3195567 | Human Services | IL | $4,872,627Mid-sized | 82.73 |
| Special Olympics ChicagoEIN 23-7026774 | Human Services | IL | $1,938,952Small | 69.94 |