| Christian Legal SocietyEIN 36-6101090 | Religion | VA | $1,386,703Small | 90.71 |
| Christian Life ResourcesEIN 39-1601307 | Religion | WI | $478,835Small | 68.93 |
| Christian Medical & Dental AssociationsEIN 36-2284267 | Religion | TN | $12,214,968Mid-sized | 89.73 |
| Christian Ministries FoundationEIN 36-2606232 | Community Development | GA | $660,233Small | 56.42 |
| Christian Motorcyclists AssociationEIN 75-1645187 | Religion | AR | $6,632,081Mid-sized | 92.55 |
| Christian Record ServicesEIN 47-0405439 | Religion | NE | $2,049,553Small | 73.82 |
| Christian Relief FundEIN 51-0183054 | International | TX | $7,338,228Mid-sized | 95.32 |
| Christian Relief Services CharitiesEIN 91-1937903 | Human Services | VA | $48,136,468Large | 90.58 |
| Christian Research InstituteEIN 22-6063412 | Religion | NC | $4,231,851Mid-sized | 71.88 |
| Christian Salvation ServiceEIN 98-0085066 | International | CA | $1,550,401Small | 64.06 |
| Christian Service Center for Central FloridaEIN 59-1353031 | Human Services | FL | $1,396,639Small | 84.23 |
| Christian ServicesEIN 64-0730835 | Human Services | MS | $915,591Small | 92.85 |
| Christian Solidarity InternationalEIN 33-0826951 | Religion | CA | $1,186,127Small | 88.46 |
| Christian UnionEIN 22-3834440 | Religion | NJ | $10,913,876Mid-sized | 89.74 |
| Christian World OutreachEIN 84-1445744 | International | CO | $893,873Small | 91.99 |
| Christine Ann Domestic Abuse ServicesEIN 39-1441770 | Human Services | WI | $1,271,189Small | 81.30 |
| ChrysalisEIN 95-3972624 | Human Services | CA | $18,364,058Large | 92.92 |
| Chrysalis Shelter for Victims of Domestic ViolenceEIN 86-0447620 | Human Services | AZ | $2,974,397Small | 88.45 |
| Chrysler Museum of ArtEIN 51-0243196 | Arts, Culture, Humanities | VA | $10,789,489Mid-sized | 90.90 |
| CHUMEIN 41-1227969 | Human Services | MN | $2,486,042Small | 90.23 |
| Church Health EIN 58-1716113 | Health | TN | $20,797,265Large | 94.58 |
| Church Hill Activities and TutoringEIN 20-0220263 | Education | VA | $2,156,767Small | 94.70 |
| Church World ServiceEIN 13-4080201 | International | IN | $65,527,734Large | 83.94 |
| Churches of Christ Disaster Relief EffortEIN 62-1560072 | Human Services | TN | $7,348,103Mid-sized | 85.15 |
| CIA Officers Memorial FoundationEIN 52-2360463 | Human Services | VA | $1,536,236Small | 99.25 |
| Cibolo Nature Center & FarmEIN 74-2564700 | Environment | TX | $3,672,517Mid-sized | 85.33 |
| Cincinnati Art MuseumEIN 31-0536653 | Arts, Culture, Humanities | OH | $14,729,738Large | 94.04 |
| Cincinnati BalletEIN 31-6050354 | Arts, Culture, Humanities | OH | $9,444,521Mid-sized | 87.20 |
| Cincinnati Nature CenterEIN 31-6057978 | Environment | OH | $4,653,544Mid-sized | 77.13 |
| Cincinnati OperaEIN 31-0549044 | Arts, Culture, Humanities | OH | $7,768,378Mid-sized | 90.18 |
| Cincinnati Parks FoundationEIN 31-1429016 | Environment | OH | $1,059,563Small | 89.02 |
| Cincinnati Public RadioEIN 31-1410636 | Arts, Culture, Humanities | OH | $5,945,935Mid-sized | 86.02 |
| Cincinnati Symphony OrchestraEIN 31-0537080 | Arts, Culture, Humanities | OH | $31,381,796Large | 91.96 |
| Cincinnati WorksEIN 31-1656186 | Human Services | OH | $3,222,679Small | 90.28 |
| Cincinnati Zoo & Botanical GardenEIN 31-0537171 | Animals | OH | $43,193,066Large | 90.73 |
| CinequestEIN 77-0250734 | Arts, Culture, Humanities | CA | $1,297,850Small | 88.19 |
| Circle Health ServicesEIN 23-7078501 | Health | OH | $5,547,953Mid-sized | 88.77 |
| Circle Of ConcernEIN 23-7085010 | Human Services | MO | $2,170,713Small | 86.52 |
| CIS Development FoundationEIN 22-3304404 | International | NJ | $41,239,855Large | 83.73 |
| CitiHope Relief & DevelopmentEIN 13-2907656 | International | NY | $148,169,686Large | 95.05 |
| Citizen SchoolsEIN 04-3259160 | Education | MA | $20,565,491Large | 85.00 |
| Citizens Against Government WasteEIN 52-1363952 | Human and Civil Rights | DC | $3,768,713Mid-sized | 83.69 |
| Citizens Commission on Human RightsEIN 68-0005541 | Human and Civil Rights | CA | $3,592,409Mid-sized | 80.30 |
| Citizens Committee for New York CityEIN 51-0171818 | Community Development | NY | $2,613,376Small | 93.18 |
| Citizens for Animal ProtectionEIN 23-7296260 | Animals | TX | $3,498,478Small | 90.68 |
| Citizens for Global Solutions Education FundEIN 52-6081813 | International | DC | $168,324Small | 72.93 |
| Citizens for Responsibility and Ethics in WashingtonEIN 03-0445391 | Human and Civil Rights | DC | $1,995,677Small | 81.04 |
| Citizens United for Research in EpilepsyEIN 36-4253176 | Health | IL | $6,070,422Mid-sized | 96.46 |
| Citizens United FoundationEIN 54-1626748 | Human and Civil Rights | DC | $3,554,360Mid-sized | 56.74 |
| Citizens' Committee for Children of New YorkEIN 13-5618593 | Human Services | NY | $2,913,471Small | 88.26 |
| Citrus Center Boys & Girls ClubEIN 59-0776417 | Human Services | FL | $1,022,421Small | 73.61 |
| City AcademyEIN 31-1619379 | Education | MO | $3,936,148Mid-sized | 86.36 |
| City HarvestEIN 13-3170676 | Human Services | NY | $123,039,582Large | 87.08 |
| City ImpactEIN 47-0800906 | Religion | NE | $1,076,962Small | 75.66 |
| City MissionEIN 25-1051749 | Human Services | PA | $6,720,515Mid-sized | 82.31 |
| City Mission of SchenectadyEIN 14-1403652 | Human Services | NY | $5,157,949Mid-sized | 99.34 |
| City of RefugeEIN 58-2194642 | Human Services | GA | $8,064,665Mid-sized | 86.10 |
| City Parks FoundationEIN 13-3561657 | Environment | NY | $20,273,100Large | 94.26 |
| City Rescue MissionEIN 59-1009115 | Human Services | FL | $5,461,593Mid-sized | 79.84 |
| City Rescue Mission of LansingEIN 38-1626400 | Human Services | MI | $3,402,158Small | 91.71 |