| Edgewood Children's RanchEIN 59-1150182 | Human Services | FL | $1,868,366Small | 93.28 |
| Educando by WorldfundEIN 03-0483824 | International | DC | $2,874,579Small | 94.18 |
| Education Foundation of Palm Beach CountyEIN 59-2420369 | Education | FL | $2,400,649Small | 92.92 |
| Education Law CenterEIN 22-2014555 | Human and Civil Rights | NJ | $1,953,793Small | 85.06 |
| Education Writers AssociationEIN 23-7439790 | Education | DC | $2,594,778Small | 90.26 |
| EdVestorsEIN 76-0794873 | Education | MA | $3,232,210Small | 84.68 |
| EFRAT-C.R.I.B. Committee for the Rescue of Israel's BabiesEIN 22-3431457 | Human Services | NY | $2,588,353Small | 86.13 |
| Eisenhower FoundationEIN 48-0634284 | Arts, Culture, Humanities | KS | $2,432,358Small | 77.15 |
| El Hogar MinistriesEIN 04-3580644 | International | MA | $1,498,436Small | 91.26 |
| El Museo del BarrioEIN 23-7156720 | Arts, Culture, Humanities | NY | $3,296,157Small | 74.33 |
| ElderHelp of San DiegoEIN 95-2880426 | Human Services | CA | $1,169,210Small | 92.85 |
| Ele's PlaceEIN 38-2976751 | Human Services | MI | $2,794,372Small | 87.66 |
| Electronic Privacy Information CenterEIN 52-2225921 | Human and Civil Rights | DC | $1,523,199Small | 97.17 |
| ELEM/Youth in Distress in IsraelEIN 13-3171815 | Human Services | NY | $888,375Small | 74.55 |
| Elie Wiesel Foundation for HumanityEIN 13-3398151 | International | NY | $1,039,897Small | 80.59 |
| Elijah's PromiseEIN 22-3055539 | Human Services | NJ | $2,160,208Small | 89.02 |
| Elk Grove Food Bank ServicesEIN 38-3664737 | Human Services | CA | $2,664,368Small | 83.01 |
| Elmbrook Humane SocietyEIN 39-6091712 | Animals | WI | $1,164,047Small | 89.63 |
| ElunaEIN 91-2065051 | Human Services | PA | $2,819,395Small | 91.13 |
| Emerald Coast Children's Advocacy CenterEIN 59-3454168 | Human Services | FL | $1,242,926Small | 90.70 |
| Emerald Necklace ConservancyEIN 04-3414988 | Environment | MA | $1,687,443Small | 83.01 |
| Emergency Infant ServicesEIN 73-1039524 | Human Services | OK | $3,126,481Small | 95.47 |
| Emergency Medicine FoundationEIN 75-2331221 | Health | TX | $2,548,384Small | 94.34 |
| Emily K CenterEIN 56-2230469 | Human Services | NC | $2,219,274Small | 91.11 |
| Emmaus H.O.M.E.EIN 01-0287624 | Community Development | ME | $1,561,527Small | 72.60 |
| Empowering Lives InternationalEIN 33-0610787 | International | CA | $1,459,122Small | 79.89 |
| enCourage Kids FoundationEIN 13-3442216 | Health | NY | $3,110,680Small | 89.25 |
| Endometriosis AssociationEIN 39-1414754 | Health | WI | $337,741Small | 73.20 |
| endPoverty.orgEIN 54-1371549 | International | VA | $501,476Small | 76.19 |
| ENLACE USAEIN 04-3675191 | International | CA | $1,701,249Small | 81.89 |
| Ensemble Theater CompanyEIN 95-3408200 | Arts, Culture, Humanities | CA | $2,506,179Small | 90.58 |
| Environment America Research and Policy CenterEIN 13-4339865 | Environment | CO | $3,179,487Small | 83.13 |
| Environmental Advocates of New YorkEIN 22-2360736 | Environment | NY | $1,251,586Small | 99.79 |
| Environmental and Energy Study InstituteEIN 52-1268030 | Environment | DC | $1,296,571Small | 100.00 |
| Environmental Defense CenterEIN 77-0061994 | Environment | CA | $1,135,564Small | 90.57 |
| Environmental Grantmakers AssociationEIN 20-8817646 | Environment | NY | $2,539,563Small | 91.44 |
| Environmental InitiativeEIN 41-1718834 | Environment | MN | $2,064,185Small | 96.07 |
| Environmental Integrity ProjectEIN 20-1326922 | Environment | DC | $3,168,637Small | 84.42 |
| Environmental Law Alliance WorldwideEIN 94-3116602 | Environment | OR | $1,816,495Small | 95.34 |
| Environmental Research and Education FoundationEIN 52-1804051 | Environment | NC | $2,511,072Small | 95.50 |
| Environmental Traveling CompanionsEIN 51-0158789 | Human Services | CA | $1,111,244Small | 78.76 |
| EOD Warrior FoundationEIN 20-8618412 | Human Services | FL | $1,378,932Small | 92.02 |
| Epilepsy Foundation of MinnesotaEIN 41-0874541 | Health | MN | $2,228,406Small | 87.22 |
| Epilepsy Foundation of TexasEIN 74-2141084 | Health | TX | $2,624,467Small | 89.60 |
| Episcopal Charities of the Diocese of New YorkEIN 13-3902908 | Human Services | NY | $1,785,346Small | 86.42 |
| Equal Justice AmericaEIN 13-3708596 | Human and Civil Rights | VA | $1,109,390Small | 73.99 |
| Equal Rights AdvocatesEIN 23-7217027 | Human and Civil Rights | CA | $1,623,252Small | 80.47 |
| Equality California InstituteEIN 68-0438008 | Human and Civil Rights | CA | $1,960,521Small | 90.71 |
| Equality Florida InstituteEIN 59-3435235 | Human and Civil Rights | FL | $2,652,749Small | 92.03 |
| EquestEIN 75-1823701 | Human Services | TX | $1,784,585Small | 85.71 |
| Equine AdvocatesEIN 11-3313534 | Animals | NY | $1,445,721Small | 87.52 |
| Eric Carle Museum of Picture Book ArtEIN 04-3542086 | Arts, Culture, Humanities | MA | $3,180,878Small | 84.43 |
| ESCAPE Family Resource CenterEIN 76-0029184 | Human Services | TX | $1,330,222Small | 75.99 |
| Española HumaneEIN 85-0406234 | Animals | NM | $1,802,326Small | 91.91 |
| Esperanza International FoundationEIN 91-1585511 | International | TX | $1,325,567Small | 82.43 |
| eTownEIN 84-1186181 | Arts, Culture, Humanities | CO | $2,265,458Small | 88.49 |
| Evangelism Missions Inc.EIN 59-1712184 | Religion | AL | $624,514Small | 58.32 |
| Evangelistic Outreach MinistriesEIN 23-7299935 | Religion | OH | $1,273,615Small | 73.32 |
| Evansville MuseumEIN 35-0874517 | Arts, Culture, Humanities | IN | $2,213,959Small | 83.28 |
| EvanTellEIN 23-7281987 | Religion | TX | $1,398,742Small | 83.52 |