| Dikembe Mutombo FoundationEIN 58-2359589 | International | GA | $3,333,046Small | 75.95 |
| Dining for WomenEIN 20-0031928 | International | SC | $1,423,715Small | 88.01 |
| Disabled Police and Sheriff's FoundationEIN 36-4494026 | Human Services | MO | $2,265,836Small | 21.56 |
| Discovery Center of SpringfieldEIN 43-1568214 | Arts, Culture, Humanities | MO | $1,154,192Small | 85.38 |
| Discovery Eye FoundationEIN 95-4228653 | Health | CA | $897,538Small | 69.62 |
| Discovery MuseumEIN 04-2741645 | Arts, Culture, Humanities | MA | $1,841,437Small | 87.63 |
| Diskin Orphan Fund of IsraelEIN 13-5608399 | Human Services | NY | $1,817,844Small | 75.86 |
| Doctors CareEIN 84-1150815 | Health | CO | $2,543,801Small | 95.05 |
| Dogs for Better LivesEIN 93-0681311 | Animals | OR | $3,363,233Small | 95.93 |
| Dogwood AllianceEIN 56-2139120 | Environment | NC | $1,552,587Small | 88.31 |
| Dollywood FoundationEIN 62-1348105 | Education | TN | $2,763,686Small | 84.26 |
| Domestic Abuse Intervention ServicesEIN 39-1268238 | Human Services | WI | $3,256,031Small | 93.70 |
| Domestic Abuse ProjectEIN 41-1356278 | Human Services | MN | $1,595,408Small | 76.76 |
| Domestic Abuse Project of Delaware CountyEIN 23-2053144 | Human Services | PA | $1,766,699Small | 90.06 |
| Domestic Violence Center of Chester CountyEIN 22-2606511 | Human Services | PA | $1,767,014Small | 88.49 |
| Domestic Violence ProjectEIN 34-1263226 | Human Services | OH | $1,759,397Small | 86.59 |
| Domestic Violence Solutions for Santa Barbara CountyEIN 95-3495141 | Human Services | CA | $1,830,345Small | 84.41 |
| Donald W. Reynolds Boys & Girls ClubEIN 71-0254287 | Human Services | AR | $2,246,524Small | 88.23 |
| Doug Flutie Jr. Foundation For AutismEIN 04-3543134 | Health | MA | $1,281,666Small | 87.31 |
| Downline MinistriesEIN 20-1374884 | Religion | TN | $1,631,991Small | 80.75 |
| Downtown Community Television CenterEIN 13-2742777 | Arts, Culture, Humanities | NY | $3,066,888Small | 91.45 |
| Dr. Susan Love Research FoundationEIN 77-0009065 | Health | CA | $2,750,486Small | 93.08 |
| Dream FactoryEIN 61-1220742 | Health | KY | $2,252,925Small | 92.38 |
| Dreamchaser PMU Rescue & RehabilitationEIN 20-5168546 | Animals | MO | $1,306,857Small | 68.73 |
| Dreams Come TrueEIN 59-2967803 | Health | FL | $2,459,405Small | 92.22 |
| Dress for Success HoustonEIN 76-0579697 | Human Services | TX | $2,618,328Small | 94.63 |
| Drisha Institute for Jewish EducationEIN 13-2968932 | Religion | NY | $2,333,063Small | 75.76 |
| Dubuque Regional Humane SocietyEIN 42-6039535 | Animals | IA | $1,228,456Small | 83.90 |
| Dutchess County SPCAEIN 14-1340058 | Animals | NY | $2,016,618Small | 85.23 |
| Dysautonomia FoundationEIN 13-6145280 | Health | NY | $2,427,386Small | 85.38 |
| Dystonia Medical Research FoundationEIN 95-3378526 | Health | IL | $2,608,986Small | 95.85 |
| Dystrophic Epidermolysis Bullosa Research Association of America (debra of America)EIN 11-2519726 | Health | NY | $1,416,573Small | 93.82 |
| dZi FoundationEIN 84-1595852 | International | CO | $1,351,526Small | 94.74 |
| Eagle MountEIN 84-1383214 | Health | MT | $1,623,071Small | 91.51 |
| Eagles Charitable FoundationEIN 23-2794290 | Human Services | PA | $1,448,292Small | 84.23 |
| Earth Conservation CorpsEIN 52-1683270 | Environment | DC | $350,700Small | 74.09 |
| Earth Day NetworkEIN 13-3798288 | Environment | DC | $2,970,282Small | 91.94 |
| Earth ForceEIN 52-1830873 | Environment | CO | $1,002,263Small | 84.00 |
| EarthEcho InternationalEIN 95-4789334 | Environment | DC | $698,764Small | 82.66 |
| EarthplaceEIN 06-0740523 | Environment | CT | $2,425,838Small | 85.32 |
| EarthRights InternationalEIN 04-3265555 | International | DC | $3,343,499Small | 99.01 |
| EarthShare CaliforniaEIN 94-2840364 | Environment | CA | $1,349,632Small | 73.23 |
| EarthShare GeorgiaEIN 58-2022001 | Environment | GA | $635,892Small | 80.68 |
| EarthShare TexasEIN 74-2627643 | Environment | TX | $407,224Small | 84.86 |
| EARTHWORKSEIN 52-1557765 | Environment | DC | $3,301,953Small | 94.74 |
| East Bay Alliance for A Sustainable EconomyEIN 94-3314108 | Human Services | CA | $1,290,909Small | 91.25 |
| East Cooper Community OutreachEIN 57-0939280 | Human Services | SC | $1,871,995Small | 97.17 |
| East End HouseEIN 04-2104163 | Human Services | MA | $2,610,655Small | 80.06 |
| East Tennessee PBSEIN 62-1173293 | Arts, Culture, Humanities | TN | $3,188,133Small | 90.71 |
| East Texas Crisis CenterEIN 75-1641173 | Human Services | TX | $2,141,385Small | 86.52 |
| East-West Center FoundationEIN 99-0218752 | International | HI | $819,979Small | 83.27 |
| Eastern Music FestivalEIN 56-0771005 | Arts, Culture, Humanities | NC | $2,334,231Small | 81.51 |
| Eastside Community MinistryEIN 31-0952074 | Human Services | OH | $698,117Small | 67.57 |
| Ebenezer Christian Children's HomeEIN 56-1861709 | Human Services | NC | $2,295,078Small | 82.89 |
| ECAD, Educated Canines Assisting with DisabilitiesEIN 06-1436718 | Animals | CT | $895,834Small | 92.92 |
| ECHO (Everyone Cooperating to Help Others)EIN 39-1222279 | Human Services | WI | $2,388,786Small | 92.59 |
| ECHO Lake Aquarium and Science CenterEIN 03-0347288 | Arts, Culture, Humanities | VT | $3,464,446Small | 91.45 |
| ECHO of BrandonEIN 59-3051533 | Human Services | FL | $1,536,158Small | 78.95 |
| EcoLogic Development FundEIN 25-1704582 | Environment | MA | $1,487,137Small | 81.51 |
| Ecology CenterEIN 38-1912803 | Environment | MI | $1,941,562Small | 93.09 |