| Rainbow AcresEIN 86-0286420 | Human Services | AZ | $4,987,515Mid-sized | 82.26 |
| Rape, Abuse & Incest National NetworkEIN 52-1886511 | Human Services | DC | $6,409,790Mid-sized | 84.81 |
| Raphael House of PortlandEIN 93-0710963 | Human Services | OR | $2,069,832Small | 93.31 |
| REACH Beyond Domestic ViolenceEIN 04-2735449 | Human Services | MA | $2,038,047Small | 83.65 |
| REDFEIN 54-2132153 | Human Services | CA | $13,282,944Mid-sized | 95.33 |
| Religious Community ServicesEIN 59-1309186 | Human Services | FL | $9,886,130Mid-sized | 91.45 |
| ReSOURCEEIN 03-0326293 | Human Services | VT | $4,244,228Mid-sized | 88.17 |
| Resource and Crisis Center of Galveston CountyEIN 76-0121011 | Human Services | TX | $2,645,730Small | 91.88 |
| ReVive Center for Housing and HealingEIN 36-2192804 | Human Services | IL | $2,298,503Small | 85.05 |
| Rising Tide CapitalEIN 11-3720098 | Human Services | NJ | $4,068,979Mid-sized | 95.65 |
| Rockwall County Helping HandsEIN 75-2402276 | Human Services | TX | $2,821,282Small | 85.89 |
| Rose Brooks CenterEIN 51-0231573 | Human Services | MO | $6,361,265Mid-sized | 90.48 |
| Sabathani Community CenterEIN 41-0984859 | Human Services | MN | $2,184,671Small | 86.37 |
| Sacramento Loaves & FishesEIN 68-0189897 | Human Services | CA | $6,533,895Mid-sized | 96.86 |
| Sacred Heart CenterEIN 46-0417196 | Human Services | SD | $4,556,342Mid-sized | 68.70 |
| Sacred Heart Community ServiceEIN 23-7179787 | Human Services | CA | $22,848,309Large | 93.77 |
| Saddle Up!EIN 58-1930303 | Human Services | TN | $1,055,317Small | 87.81 |
| Safe ConnectionsEIN 43-1077667 | Human Services | MO | $2,357,049Small | 90.14 |
| Safe Nest: Temporary Assistance for Domestic CrisisEIN 94-2411883 | Human Services | NV | $5,347,813Mid-sized | 76.21 |
| Safe Place of the Permian BasinEIN 75-1657264 | Human Services | TX | $1,809,322Small | 85.44 |
| SafeHaven of Tarrant CountyEIN 75-1670281 | Human Services | TX | $7,907,012Mid-sized | 92.70 |
| SAFEHOMEEIN 48-0917798 | Human Services | KS | $3,636,486Mid-sized | 96.19 |
| SafeHouse CenterEIN 38-2121751 | Human Services | MI | $2,244,935Small | 93.08 |
| SAGE EldercareEIN 22-1657929 | Human Services | NJ | $3,605,635Mid-sized | 86.41 |
| Samaritan HouseEIN 23-7416272 | Human Services | CA | $10,205,305Mid-sized | 94.93 |
| San Diego Second Chance ProgramEIN 33-0539640 | Human Services | CA | $6,021,277Mid-sized | 87.55 |
| Sanctuary for FamiliesEIN 13-3193119 | Human Services | NY | $21,026,926Large | 92.24 |
| SBH Community Service NetworkEIN 23-7406410 | Human Services | NY | $9,752,470Mid-sized | 96.54 |
| Search and CareEIN 23-7444790 | Human Services | NY | $1,381,511Small | 94.70 |
| Second HelpingsEIN 35-1484281 | Human Services | IN | $6,711,056Mid-sized | 98.23 |
| SECOREIN 20-4226894 | Human Services | CO | $4,048,217Mid-sized | 72.61 |
| Senior ConcernsEIN 95-2992927 | Human Services | CA | $1,864,713Small | 84.52 |
| Senior Link MidlandEIN 75-1899190 | Human Services | TX | $2,885,630Small | 90.74 |
| Senior NeighborsEIN 23-7195491 | Human Services | MI | $3,594,979Mid-sized | 94.69 |
| Senior ServicesEIN 56-1085968 | Human Services | NC | $6,935,007Mid-sized | 95.38 |
| Senior Services Inc. of WichitaEIN 48-0757988 | Human Services | KS | $2,430,872Small | 86.19 |
| Sephardic Food Fund EIN 56-2307777 | Human Services | NY | $2,663,245Small | 61.26 |
| Service Over SelfEIN 62-1760415 | Human Services | TN | $1,554,211Small | 84.96 |
| Sexual Assault CenterEIN 62-1043294 | Human Services | TN | $2,597,107Small | 91.17 |
| Shane's InspirationEIN 95-4760497 | Human Services | CA | $2,205,495Small | 83.43 |
| Share Our StrengthEIN 52-1367538 | Human Services | DC | $51,056,766Large | 80.07 |
| Sharing ConnectionsEIN 36-4363123 | Human Services | IL | $2,816,731Small | 90.62 |
| Sharing HouseEIN 56-1292875 | Human Services | NC | $1,429,960Small | 89.52 |
| Sheltering Wings Center for WomenEIN 35-2077713 | Human Services | IN | $1,678,269Small | 92.18 |
| Shepherd Community CenterEIN 35-1765846 | Human Services | IN | $6,208,023Mid-sized | 90.47 |
| Shoreline Soup Kitchens & PantriesEIN 46-3773017 | Human Services | CT | $1,555,411Small | 93.84 |
| Single Stop USAEIN 20-8837690 | Human Services | NY | $21,924,829Large | 80.68 |
| SnowCap Community CharitiesEIN 23-7121915 | Human Services | OR | $4,003,598Mid-sized | 96.53 |
| Soaring EagleEIN 84-1409114 | Human Services | MT | $3,535,909Mid-sized | 79.67 |
| Society of St. Vincent De Paul Archdiocesan Council of St. LouisEIN 43-0652684 | Human Services | MO | $23,619,507Large | 92.02 |
| Society of St. Vincent de Paul ChicagoEIN 36-3195567 | Human Services | IL | $4,872,627Mid-sized | 82.73 |
| Society of St. Vincent de Paul of Alameda CountyEIN 94-1156493 | Human Services | CA | $5,959,918Mid-sized | 84.57 |
| Society of St. Vincent de Paul of San Mateo CountyEIN 94-1375833 | Human Services | CA | $6,229,067Mid-sized | 87.77 |
| Society of St. Vincent de Paul, Portland CouncilEIN 93-0456525 | Human Services | OR | $7,058,723Mid-sized | 86.84 |
| Sojourner CenterEIN 94-2465081 | Human Services | AZ | $7,335,341Mid-sized | 72.33 |
| Sojourner Family Peace CenterEIN 39-1276210 | Human Services | WI | $7,587,653Mid-sized | 83.73 |
| Soldiers' AngelsEIN 20-0583415 | Human Services | TX | $18,391,429Large | 94.28 |
| South Boston Neighborhood HouseEIN 04-2104807 | Human Services | MA | $1,756,067Small | 84.90 |
| Southern Partners FundEIN 58-2409301 | Human Services | GA | $1,225,922Small | 77.64 |
| Southwest Christian CareEIN 58-1849504 | Human Services | GA | $2,109,260Small | 73.34 |