| Second Stage TheatreEIN 13-3021180 | Arts, Culture, Humanities | NY | $9,254,856Mid-sized | 77.08 |
| Segerstrom Center for the ArtsEIN 23-7287150 | Arts, Culture, Humanities | CA | $69,295,404Large | 89.82 |
| Senator John Heinz History Center- Historical Society of Western PennsylvaniaEIN 25-0965391 | Arts, Culture, Humanities | PA | $11,115,252Mid-sized | 90.62 |
| SFFILMEIN 94-2663216 | Arts, Culture, Humanities | CA | $6,042,427Mid-sized | 87.22 |
| SFJAZZEIN 94-2990335 | Arts, Culture, Humanities | CA | $16,924,582Large | 84.54 |
| Shakespeare & CompanyEIN 04-2666826 | Arts, Culture, Humanities | MA | $4,795,855Mid-sized | 82.41 |
| Shakespeare Theatre CompanyEIN 52-1405988 | Arts, Culture, Humanities | DC | $21,930,518Large | 87.67 |
| Sharon Lynne Wilson Center for the ArtsEIN 39-1787648 | Arts, Culture, Humanities | WI | $2,952,831Small | 78.38 |
| Shelburne Museum EIN 03-0179436 | Arts, Culture, Humanities | VT | $6,774,923Mid-sized | 84.15 |
| SIFFEIN 91-1489660 | Arts, Culture, Humanities | WA | $6,896,394Mid-sized | 73.81 |
| Silicon Valley CreatesEIN 94-2825213 | Arts, Culture, Humanities | CA | $2,479,545Small | 88.98 |
| SilkroadEIN 04-3444069 | Arts, Culture, Humanities | MA | $4,595,602Mid-sized | 87.29 |
| SITE Santa FeEIN 85-0413922 | Arts, Culture, Humanities | NM | $2,574,910Small | 88.61 |
| Skirball Cultural CenterEIN 95-4538371 | Arts, Culture, Humanities | CA | $25,294,003Large | 87.83 |
| Skylight Music TheatreEIN 39-0975374 | Arts, Culture, Humanities | WI | $3,499,182Small | 78.63 |
| Smoky Hills Public TelevisionEIN 48-0874906 | Arts, Culture, Humanities | KS | $1,840,013Small | 79.50 |
| Smuin BalletEIN 94-3197247 | Arts, Culture, Humanities | CA | $4,135,237Mid-sized | 88.33 |
| Society of the CincinnatiEIN 53-0205423 | Arts, Culture, Humanities | DC | $4,196,909Mid-sized | 88.52 |
| Society of the Four ArtsEIN 59-0454318 | Arts, Culture, Humanities | FL | $8,133,941Mid-sized | 86.63 |
| Solomon R. Guggenheim FoundationEIN 13-5562233 | Arts, Culture, Humanities | NY | $80,072,379Large | 78.32 |
| South Coast RepertoryEIN 95-6122708 | Arts, Culture, Humanities | CA | $11,651,004Mid-sized | 86.11 |
| South Dakota Symphony OrchestraEIN 46-6017026 | Arts, Culture, Humanities | SD | $1,927,737Small | 83.34 |
| South Florida MuseumEIN 59-0598726 | Arts, Culture, Humanities | FL | $3,401,335Small | 87.76 |
| South Florida PBSEIN 59-0737868 | Arts, Culture, Humanities | FL | $18,553,742Large | 78.65 |
| South Florida Science Center and AquariumEIN 59-0915177 | Arts, Culture, Humanities | FL | $3,583,072Mid-sized | 90.59 |
| South Street Seaport MuseumEIN 13-2596500 | Arts, Culture, Humanities | NY | $3,179,707Small | 82.13 |
| Southern California Public RadioEIN 95-4765734 | Arts, Culture, Humanities | CA | $27,593,781Large | 85.94 |
| Spoleto Festival USAEIN 57-0660848 | Arts, Culture, Humanities | SC | $8,737,036Mid-sized | 82.85 |
| Springfield Library and Museums AssociationEIN 04-6002239 | Arts, Culture, Humanities | MA | $7,616,989Mid-sized | 87.57 |
| St. Louis Public Library FoundationEIN 43-1541947 | Arts, Culture, Humanities | MO | $744,456Small | 79.60 |
| Stamford Center for the ArtsEIN 06-1048684 | Arts, Culture, Humanities | CT | $3,601,344Mid-sized | 86.08 |
| Stamford Symphony OrchestraEIN 06-6100039 | Arts, Culture, Humanities | CT | $1,439,725Small | 80.32 |
| Stan Hywet Hall & GardensEIN 34-0819149 | Arts, Culture, Humanities | OH | $5,263,087Mid-sized | 73.90 |
| State Street BalletEIN 86-0717486 | Arts, Culture, Humanities | CA | $1,295,799Small | 80.63 |
| Statue of Liberty-Ellis Island FoundationEIN 13-3118415 | Arts, Culture, Humanities | NY | $18,817,780Large | 92.24 |
| Stern Grove Festival AssociationEIN 94-6064356 | Arts, Culture, Humanities | CA | $2,645,452Small | 80.95 |
| Storm King Art CenterEIN 14-1457573 | Arts, Culture, Humanities | NY | $8,396,023Mid-sized | 89.00 |
| StoryCorpsEIN 13-3753011 | Arts, Culture, Humanities | NY | $10,638,243Mid-sized | 94.93 |
| StrathmoreEIN 52-1233092 | Arts, Culture, Humanities | MD | $12,121,219Mid-sized | 90.00 |
| Strawbery Banke MuseumEIN 02-0260158 | Arts, Culture, Humanities | NH | $3,204,942Small | 93.92 |
| Strings Music FestivalEIN 84-1101995 | Arts, Culture, Humanities | CO | $2,051,356Small | 89.13 |
| Studio Museum in HarlemEIN 13-2590805 | Arts, Culture, Humanities | NY | $7,761,083Mid-sized | 88.58 |
| Sundance InstituteEIN 87-0361394 | Arts, Culture, Humanities | CA | $42,985,822Large | 88.22 |
| Sunvalley Summer SymphonyEIN 82-0397940 | Arts, Culture, Humanities | ID | $3,471,245Small | 83.13 |
| Symphony Orchestra AugustaEIN 58-1806334 | Arts, Culture, Humanities | GA | $1,329,082Small | 71.30 |
| Symphony Silicon ValleyEIN 32-0083030 | Arts, Culture, Humanities | CA | $3,744,844Mid-sized | 83.56 |
| Symphony SpaceEIN 13-2941455 | Arts, Culture, Humanities | NY | $6,686,548Mid-sized | 91.83 |
| Symphony TacomaEIN 91-6032976 | Arts, Culture, Humanities | WA | $1,209,023Small | 77.32 |
| Syracuse StageEIN 15-0623468 | Arts, Culture, Humanities | NY | $5,682,361Mid-sized | 84.78 |
| TACAEIN 75-6061186 | Arts, Culture, Humanities | TX | $2,449,418Small | 88.02 |
| Tacoma Art MuseumEIN 91-0697444 | Arts, Culture, Humanities | WA | $5,952,363Mid-sized | 86.03 |
| Taubman Museum of ArtEIN 54-6026841 | Arts, Culture, Humanities | VA | $4,213,597Mid-sized | 88.16 |
| Telfair Museum of ArtEIN 58-0610074 | Arts, Culture, Humanities | GA | $6,217,237Mid-sized | 85.62 |
| Ten Chimneys FoundationEIN 39-1862290 | Arts, Culture, Humanities | WI | $999,353Small | 82.29 |
| Texas Ballet TheaterEIN 84-1622654 | Arts, Culture, Humanities | TX | $8,289,958Mid-sized | 86.07 |
| Texas Cultural TrustEIN 74-2778878 | Arts, Culture, Humanities | TX | $2,233,098Small | 86.56 |
| Texas Public RadioEIN 74-2559514 | Arts, Culture, Humanities | TX | $4,888,453Mid-sized | 95.17 |
| Texas State Historical AssociationEIN 74-6025220 | Arts, Culture, Humanities | TX | $2,690,694Small | 79.26 |
| The Abraham Lincoln FoundationEIN 23-2822856 | Arts, Culture, Humanities | PA | $1,233,060Small | 77.53 |
| The Academy of Natural Sciences of Drexel UniversityEIN 23-1352000 | Arts, Culture, Humanities | PA | $20,069,886Large | 88.54 |