| COSI Center of Science and IndustryEIN 31-4383802 | Arts, Culture, Humanities | OH | $17,916,053Large | 85.79 |
| Country Music FoundationEIN 62-0753887 | Arts, Culture, Humanities | TN | $31,719,231Large | 80.61 |
| Creative Capital FoundationEIN 31-1605982 | Arts, Culture, Humanities | NY | $5,792,226Mid-sized | 92.38 |
| Creative TimeEIN 13-2835847 | Arts, Culture, Humanities | NY | $2,920,073Small | 86.13 |
| Creede Repertory TheatreEIN 84-0660026 | Arts, Culture, Humanities | CO | $1,623,226Small | 91.03 |
| Crooked Tree Arts CenterEIN 23-7187264 | Arts, Culture, Humanities | MI | $2,194,400Small | 82.56 |
| Crow Canyon Archaeological CenterEIN 84-0631786 | Arts, Culture, Humanities | CO | $4,488,765Mid-sized | 86.52 |
| CuriOdysseyEIN 94-1262434 | Arts, Culture, Humanities | CA | $4,418,168Mid-sized | 86.57 |
| Curious Theatre CompanyEIN 84-1364297 | Arts, Culture, Humanities | CO | $1,227,492Small | 79.93 |
| Dallas ContemporaryEIN 75-1575687 | Arts, Culture, Humanities | TX | $1,826,588Small | 87.23 |
| Dallas Holocaust MuseumEIN 75-2113723 | Arts, Culture, Humanities | TX | $3,316,399Small | 84.85 |
| Dallas Museum of ArtEIN 75-0808774 | Arts, Culture, Humanities | TX | $28,537,301Large | 81.64 |
| Dallas Theater CenterEIN 75-0959992 | Arts, Culture, Humanities | TX | $10,134,614Mid-sized | 81.30 |
| Dance ExchangeEIN 52-1076232 | Arts, Culture, Humanities | MD | $447,360Small | 79.19 |
| Dance Theatre of HarlemEIN 13-2642091 | Arts, Culture, Humanities | NY | $5,536,736Mid-sized | 83.11 |
| Dance/USAEIN 52-1253457 | Arts, Culture, Humanities | DC | $2,307,036Small | 87.61 |
| Danforth ArtEIN 04-2526917 | Arts, Culture, Humanities | MA | $1,216,820Small | 75.73 |
| Daughters of the American RevolutionEIN 53-0205923 | Arts, Culture, Humanities | DC | $16,267,791Large | 75.61 |
| Dayton Art InstituteEIN 31-0537480 | Arts, Culture, Humanities | OH | $5,217,588Mid-sized | 84.58 |
| Dayton Contemporary Dance CompanyEIN 23-7220259 | Arts, Culture, Humanities | OH | $1,339,004Small | 72.01 |
| Dayton HistoryEIN 31-6037490 | Arts, Culture, Humanities | OH | $5,703,691Mid-sized | 92.22 |
| Dayton Masonic FoundationEIN 31-1385609 | Arts, Culture, Humanities | OH | $780,648Small | 80.86 |
| Dayton Performing Arts AllianceEIN 31-6000101 | Arts, Culture, Humanities | OH | $8,167,915Mid-sized | 83.97 |
| Dayton Society of Natural HistoryEIN 31-0585917 | Arts, Culture, Humanities | OH | $5,296,073Mid-sized | 79.89 |
| DeCordova Sculpture Park and MuseumEIN 04-2067315 | Arts, Culture, Humanities | MA | $4,862,222Mid-sized | 79.43 |
| Delaware Art MuseumEIN 51-0065746 | Arts, Culture, Humanities | DE | $5,189,312Mid-sized | 87.68 |
| Delaware Museum of Natural HistoryEIN 51-0083535 | Arts, Culture, Humanities | DE | $2,423,622Small | 89.09 |
| Democracy Now!EIN 01-0708733 | Arts, Culture, Humanities | NY | $7,100,320Mid-sized | 81.61 |
| Denver Art MuseumEIN 84-6038240 | Arts, Culture, Humanities | CO | $41,996,799Large | 91.19 |
| Denver Center for the Performing ArtsEIN 84-0407760 | Arts, Culture, Humanities | CO | $52,094,113Large | 83.04 |
| Denver Film SocietyEIN 84-0771070 | Arts, Culture, Humanities | CO | $4,826,421Mid-sized | 88.24 |
| Denver Public Library Friends FoundationEIN 84-6036979 | Arts, Culture, Humanities | CO | $2,403,593Small | 90.64 |
| Des Moines Art CenterEIN 42-0680419 | Arts, Culture, Humanities | IA | $8,717,426Mid-sized | 91.88 |
| Des Moines Community PlayhouseEIN 42-0710259 | Arts, Culture, Humanities | IA | $2,660,897Small | 88.27 |
| Detroit Historical SocietyEIN 38-1381144 | Arts, Culture, Humanities | MI | $5,818,479Mid-sized | 90.52 |
| Detroit Symphony OrchestraEIN 38-1385132 | Arts, Culture, Humanities | MI | $36,345,989Large | 92.06 |
| Dia Art FoundationEIN 23-7397946 | Arts, Culture, Humanities | NY | $16,546,314Large | 89.01 |
| Discovery Center of SpringfieldEIN 43-1568214 | Arts, Culture, Humanities | MO | $1,154,192Small | 85.38 |
| DISCOVERY Children's MuseumEIN 94-2943891 | Arts, Culture, Humanities | NV | $5,726,927Mid-sized | 88.33 |
| Discovery MuseumEIN 04-2741645 | Arts, Culture, Humanities | MA | $1,841,437Small | 87.63 |
| Discovery PlaceEIN 56-0529944 | Arts, Culture, Humanities | NC | $15,241,959Large | 91.91 |
| Discovery WorldEIN 39-1691578 | Arts, Culture, Humanities | WI | $9,457,339Mid-sized | 90.71 |
| Downtown Community Television CenterEIN 13-2742777 | Arts, Culture, Humanities | NY | $3,066,888Small | 91.45 |
| Dubuque County Historical SocietyEIN 42-6072050 | Arts, Culture, Humanities | IA | $7,001,981Mid-sized | 90.87 |
| DuPage Children's MuseumEIN 36-3565001 | Arts, Culture, Humanities | IL | $3,932,978Mid-sized | 84.78 |
| East Tennessee PBSEIN 62-1173293 | Arts, Culture, Humanities | TN | $3,188,133Small | 90.71 |
| Eastern Music FestivalEIN 56-0771005 | Arts, Culture, Humanities | NC | $2,334,231Small | 81.51 |
| ECHO Lake Aquarium and Science CenterEIN 03-0347288 | Arts, Culture, Humanities | VT | $3,464,446Small | 91.45 |
| EcoTariumEIN 04-2105868 | Arts, Culture, Humanities | MA | $4,965,747Mid-sized | 88.48 |
| EdVentureEIN 57-1013857 | Arts, Culture, Humanities | SC | $4,782,439Mid-sized | 86.39 |
| Eisenhower FoundationEIN 48-0634284 | Arts, Culture, Humanities | KS | $2,432,358Small | 77.15 |
| Eiteljorg Museum of American Indians and Western ArtEIN 31-1139447 | Arts, Culture, Humanities | IN | $9,127,483Mid-sized | 84.73 |
| El Museo del BarrioEIN 23-7156720 | Arts, Culture, Humanities | NY | $3,296,157Small | 74.33 |
| Ensemble Theater CompanyEIN 95-3408200 | Arts, Culture, Humanities | CA | $2,506,179Small | 90.58 |
| Eric Carle Museum of Picture Book ArtEIN 04-3542086 | Arts, Culture, Humanities | MA | $3,180,878Small | 84.43 |
| eTownEIN 84-1186181 | Arts, Culture, Humanities | CO | $2,265,458Small | 88.49 |
| ETV Endowment of South CarolinaEIN 57-0657549 | Arts, Culture, Humanities | SC | $7,062,134Mid-sized | 96.42 |
| Evansville MuseumEIN 35-0874517 | Arts, Culture, Humanities | IN | $2,213,959Small | 83.28 |
| Exploration PlaceEIN 48-1000295 | Arts, Culture, Humanities | KS | $5,298,435Mid-sized | 87.34 |
| ExploratoriumEIN 94-1696494 | Arts, Culture, Humanities | CA | $52,213,213Large | 90.09 |