| St. Louis Area FoodbankEIN 43-1253102 | Human Services | MO | $81,514,749Large | 98.86 |
| St. Mary's CenterEIN 68-0172229 | Human Services | CA | $3,039,558Small | 96.66 |
| St. Mary's Dining RoomEIN 94-2687280 | Human Services | CA | $2,522,317Small | 87.86 |
| St. Mary's Food Bank AllianceEIN 23-7353532 | Human Services | AZ | $160,093,972Large | 93.07 |
| St. Matthew's HouseEIN 65-1110501 | Human Services | FL | $7,624,221Mid-sized | 92.14 |
| St. Patrick CenterEIN 43-1263499 | Human Services | MO | $16,391,436Large | 85.08 |
| St. Vincent de Paul DetroitEIN 38-1359592 | Human Services | MI | $15,821,834Large | 89.01 |
| St. Vincent de Paul of BaltimoreEIN 52-0597056 | Human Services | MD | $20,808,081Large | 94.18 |
| St. Vincent de Paul of Seattle|King CountyEIN 91-0583891 | Human Services | WA | $10,749,665Mid-sized | 85.01 |
| St. Vincent de Paul Society of Marin CountyEIN 94-1207701 | Human Services | CA | $4,107,059Mid-sized | 96.42 |
| St. Vincent de Paul VillageEIN 33-0492302 | Human Services | CA | $31,913,973Large | 81.26 |
| St. Vincent Meals on WheelsEIN 95-3696693 | Human Services | CA | $8,085,613Mid-sized | 86.11 |
| StandUp for KidsEIN 33-0414855 | Human Services | GA | $1,220,228Small | 92.02 |
| Stanley M. Isaacs Neighborhood CenterEIN 13-2572034 | Human Services | NY | $7,899,036Mid-sized | 86.21 |
| Star of Hope MissionEIN 74-1152599 | Human Services | TX | $29,007,530Large | 86.35 |
| Starkey Hearing FoundationEIN 36-3297852 | Human Services | MN | $21,659,389Large | 92.82 |
| STARSEIN 62-1285699 | Human Services | TN | $3,850,505Mid-sized | 91.27 |
| STEPEIN 51-0188692 | Human Services | MN | $2,169,879Small | 93.36 |
| Step UpEIN 95-4701468 | Human Services | CA | $4,222,065Mid-sized | 95.14 |
| Stephen CenterEIN 36-3363994 | Human Services | NE | $3,889,802Mid-sized | 89.24 |
| Stephen Siller Tunnel to Towers FoundationEIN 02-0554654 | Human Services | NY | $16,641,583Large | 98.23 |
| Stephens Family YMCAEIN 37-0673564 | Human Services | IL | $5,276,013Mid-sized | 86.80 |
| Stewpot Community ServicesEIN 64-0655566 | Human Services | MS | $2,160,764Small | 91.15 |
| Still Creek RanchEIN 74-2614076 | Human Services | TX | $2,387,828Small | 67.40 |
| Storyteller Children's CenterEIN 77-0283072 | Human Services | CA | $1,611,343Small | 91.38 |
| Straight Ahead MinistriesEIN 04-3103694 | Human Services | MA | $2,008,144Small | 85.29 |
| Streets MinistriesEIN 62-1763815 | Human Services | TN | $2,137,688Small | 92.33 |
| STRIVEEIN 13-3255679 | Human Services | NY | $6,254,660Mid-sized | 88.95 |
| Strong City BaltimoreEIN 52-0897806 | Human Services | MD | $11,112,362Mid-sized | 90.71 |
| Students Run LAEIN 95-4430502 | Human Services | CA | $2,637,828Small | 97.10 |
| Suffolk County Police Athletic LeagueEIN 23-7356002 | Human Services | NY | $1,095,091Small | 76.76 |
| Sulzbacher CenterEIN 59-3229898 | Human Services | FL | $14,566,080Large | 92.02 |
| Sunday Breakfast MissionEIN 51-0073080 | Human Services | DE | $5,615,126Mid-sized | 79.65 |
| Sunday Breakfast Rescue MissionEIN 23-1352558 | Human Services | PA | $3,017,157Small | 79.81 |
| Sunflower HouseEIN 48-0918698 | Human Services | KS | $1,483,883Small | 93.82 |
| Sunny Glen Children's HomeEIN 74-1260706 | Human Services | TX | $2,484,409Small | 88.16 |
| Sunnyvale Community ServicesEIN 94-1713897 | Human Services | CA | $7,426,109Mid-sized | 95.10 |
| Sunshine Division Portland Police DeptEIN 93-0429354 | Human Services | OR | $5,667,244Mid-sized | 90.89 |
| Sunshine MinistriesEIN 43-0896665 | Human Services | MO | $1,553,900Small | 79.61 |
| Support The Enlisted Project (STEP)EIN 20-3051279 | Human Services | CA | $1,681,670Small | 94.41 |
| Surrey Services for SeniorsEIN 23-2610145 | Human Services | PA | $4,603,921Mid-sized | 91.37 |
| Susan B. Anthony Recovery CenterEIN 65-0583089 | Human Services | FL | $3,840,666Mid-sized | 79.43 |
| Susquehanna Council Boy Scouts of AmericaEIN 24-0795397 | Human Services | PA | $924,817Small | 86.77 |
| Sustainable Food CenterEIN 74-2441468 | Human Services | TX | $2,309,673Small | 91.45 |
| Table to TableEIN 22-3646125 | Human Services | NJ | $26,205,578Large | 98.23 |
| Tamassee DAR SchoolEIN 57-6000973 | Human Services | SC | $3,358,215Small | 91.85 |
| Tampa Metropolitan Area YMCAEIN 59-1742909 | Human Services | FL | $33,632,520Large | 92.49 |
| Tara HallEIN 23-7111696 | Human Services | SC | $1,175,001Small | 82.58 |
| Target HungerEIN 31-1548849 | Human Services | TX | $9,610,145Mid-sized | 83.45 |
| Tariq Khamisa FoundationEIN 33-0688465 | Human Services | CA | $381,431Small | 71.25 |
| Tarrant Area Food BankEIN 75-1822473 | Human Services | TX | $61,702,181Large | 94.77 |
| Taste of the NFLEIN 41-1760359 | Human Services | MN | $1,669,481Small | 70.15 |
| Teammates for Kids FoundationEIN 84-1484370 | Human Services | CO | $3,014,134Small | 94.24 |
| Tedford HousingEIN 01-0422035 | Human Services | ME | $1,500,344Small | 87.21 |
| Teen Living ProgramsEIN 36-2867274 | Human Services | IL | $2,783,106Small | 87.65 |
| Teen Parent ConnectionEIN 36-3387034 | Human Services | IL | $1,190,319Small | 92.23 |
| Tender MerciesEIN 31-1137270 | Human Services | OH | $2,937,755Small | 89.57 |
| Tennyson Center for ChildrenEIN 61-1458290 | Human Services | CO | $13,684,410Large | 91.30 |
| TGR Foundation, A Tiger Woods CharityEIN 20-0677815 | Human Services | CA | $11,035,526Mid-sized | 93.03 |
| The 52nd Street ProjectEIN 13-3467948 | Human Services | NY | $2,060,817Small | 91.70 |