| Second Harvest Inland NorthwestEIN 23-7173826 | Human Services | WA | $104,702,103Large | 93.32 |
| Second Harvest Northern Lakes Food BankEIN 36-3479964 | Human Services | MN | $10,915,737Mid-sized | 94.46 |
| Second HelpingsEIN 35-1484281 | Human Services | IN | $6,711,056Mid-sized | 98.23 |
| Second StoryEIN 54-0899463 | Human Services | VA | $3,085,749Small | 91.02 |
| SECOREIN 20-4226894 | Human Services | CO | $4,048,217Mid-sized | 72.61 |
| Self Enhancement, Inc.EIN 93-1086629 | Human Services | OR | $16,850,558Large | 86.57 |
| Senior ConcernsEIN 95-2992927 | Human Services | CA | $1,864,713Small | 84.52 |
| Senior Link MidlandEIN 75-1899190 | Human Services | TX | $2,885,630Small | 90.74 |
| Senior NeighborsEIN 23-7195491 | Human Services | MI | $3,594,979Mid-sized | 94.69 |
| Senior ServicesEIN 56-1085968 | Human Services | NC | $6,935,007Mid-sized | 95.38 |
| Senior Services Inc. of WichitaEIN 48-0757988 | Human Services | KS | $2,430,872Small | 86.19 |
| Sephardic Food Fund EIN 56-2307777 | Human Services | NY | $2,663,245Small | 61.26 |
| Service Over SelfEIN 62-1760415 | Human Services | TN | $1,554,211Small | 84.96 |
| Several Sources SheltersEIN 22-2368937 | Human Services | NJ | $2,363,897Small | 93.65 |
| Sexual Assault CenterEIN 62-1043294 | Human Services | TN | $2,597,107Small | 91.17 |
| Shalom AustinEIN 74-1469465 | Human Services | TX | $13,606,228Large | 85.00 |
| Shane's InspirationEIN 95-4760497 | Human Services | CA | $2,205,495Small | 83.43 |
| Share Our SelvesEIN 95-3222316 | Human Services | CA | $17,655,264Large | 90.63 |
| Share Our StrengthEIN 52-1367538 | Human Services | DC | $51,056,766Large | 80.07 |
| Shared Harvest FoodbankEIN 31-1096571 | Human Services | OH | $9,251,021Mid-sized | 86.64 |
| Sharing and Caring HandsEIN 36-3412619 | Human Services | MN | $8,873,662Mid-sized | 61.86 |
| Sharing ConnectionsEIN 36-4363123 | Human Services | IL | $2,816,731Small | 90.62 |
| Sharing HouseEIN 56-1292875 | Human Services | NC | $1,429,960Small | 89.52 |
| Sheffield PlaceEIN 43-1532267 | Human Services | MO | $1,187,546Small | 100.00 |
| Shelter PartnershipEIN 95-3976214 | Human Services | CA | $11,932,800Mid-sized | 93.29 |
| Sheltering Wings Center for WomenEIN 35-2077713 | Human Services | IN | $1,678,269Small | 92.18 |
| Shepherd Community CenterEIN 35-1765846 | Human Services | IN | $6,208,023Mid-sized | 90.47 |
| Shepherd's GateEIN 94-2902803 | Human Services | CA | $5,006,170Mid-sized | 88.98 |
| Shepherd's TableEIN 52-1381738 | Human Services | MD | $1,756,776Small | 87.77 |
| Sheridan House Family MinistriesEIN 59-1258384 | Human Services | FL | $4,200,026Mid-sized | 90.19 |
| Sheriff's Youth Foundation of Los Angeles CountyEIN 95-4047797 | Human Services | CA | $1,407,444Small | 87.30 |
| Sheriffs' Association of TexasEIN 74-0896285 | Human Services | TX | $2,515,085Small | 64.57 |
| Sherwood Forest CampEIN 43-0653401 | Human Services | MO | $1,738,056Small | 94.76 |
| Shiloh Christian Children's RanchEIN 43-1122941 | Human Services | MO | $1,982,671Small | 86.85 |
| Shoes and Clothes for KidsEIN 34-1554285 | Human Services | OH | $5,419,032Mid-sized | 97.17 |
| Shoes That FitEIN 95-4425565 | Human Services | CA | $5,130,693Mid-sized | 94.69 |
| Shoreline Soup Kitchens & PantriesEIN 46-3773017 | Human Services | CT | $1,555,411Small | 93.84 |
| Show HopeEIN 32-0011220 | Human Services | TN | $10,019,254Mid-sized | 77.30 |
| Show-Me Christian Youth HomeEIN 43-1861323 | Human Services | MO | $2,080,172Small | 76.44 |
| Shreveport-Bossier Rescue MissionEIN 23-7050551 | Human Services | LA | $2,151,146Small | 77.27 |
| Siena/Francis HouseEIN 47-0601005 | Human Services | NE | $8,429,303Mid-sized | 97.03 |
| Single Stop USAEIN 20-8837690 | Human Services | NY | $21,924,829Large | 80.68 |
| Sister Carmen Community CenterEIN 84-0820308 | Human Services | CO | $4,207,307Mid-sized | 90.32 |
| Sitar Arts CenterEIN 52-2113471 | Human Services | DC | $1,914,367Small | 88.36 |
| SKY Family YMCAEIN 59-1629660 | Human Services | FL | $14,895,916Large | 91.77 |
| Smoky Mountain Children's HomeEIN 23-7110635 | Human Services | TN | $8,664,116Mid-sized | 87.30 |
| SnowCap Community CharitiesEIN 23-7121915 | Human Services | OR | $4,003,598Mid-sized | 96.53 |
| Soaring EagleEIN 84-1409114 | Human Services | MT | $3,535,909Mid-sized | 79.67 |
| Sociedad LatinaEIN 04-2678255 | Human Services | MA | $1,814,005Small | 93.02 |
| Society of St. Vincent De Paul Archdiocesan Council of St. LouisEIN 43-0652684 | Human Services | MO | $23,619,507Large | 92.02 |
| Society of St. Vincent de Paul ChicagoEIN 36-3195567 | Human Services | IL | $4,872,627Mid-sized | 82.73 |
| Society of St. Vincent de Paul of Alameda CountyEIN 94-1156493 | Human Services | CA | $5,959,918Mid-sized | 84.57 |
| Society of St. Vincent de Paul of San Mateo CountyEIN 94-1375833 | Human Services | CA | $6,229,067Mid-sized | 87.77 |
| Society of St. Vincent de Paul, Portland CouncilEIN 93-0456525 | Human Services | OR | $7,058,723Mid-sized | 86.84 |
| Sojourner CenterEIN 94-2465081 | Human Services | AZ | $7,335,341Mid-sized | 72.33 |
| Sojourner Family Peace CenterEIN 39-1276210 | Human Services | WI | $7,587,653Mid-sized | 83.73 |
| Soldiers' AngelsEIN 20-0583415 | Human Services | TX | $18,391,429Large | 94.28 |
| Solid GroundEIN 36-3578158 | Human Services | MN | $1,371,215Small | 97.58 |
| Solutions for ChangeEIN 33-0902617 | Human Services | CA | $3,329,200Small | 79.52 |
| SOMEEIN 23-7098123 | Human Services | DC | $28,344,473Large | 93.11 |