| Dayspring InternationalEIN 51-0237239 | Religion | VA | $7,364,681Mid-sized | 72.03 |
| Dayton Contemporary Dance CompanyEIN 23-7220259 | Arts, Culture, Humanities | OH | $1,339,004Small | 72.01 |
| Dayton Society of Natural HistoryEIN 31-0585917 | Arts, Culture, Humanities | OH | $5,296,073Mid-sized | 79.89 |
| DeCordova Sculpture Park and MuseumEIN 04-2067315 | Arts, Culture, Humanities | MA | $4,862,222Mid-sized | 79.43 |
| Denison Pequotsepos Nature CenterEIN 06-0884024 | Environment | CT | $1,362,888Small | 76.92 |
| Detroit Lakes Community & Cultural CenterEIN 41-1970351 | Human Services | MN | $2,571,753Small | 73.98 |
| DIFFAEIN 13-3224150 | Health | NY | $2,754,888Small | 79.35 |
| Dikembe Mutombo FoundationEIN 58-2359589 | International | GA | $3,333,046Small | 75.95 |
| Diskin Orphan Fund of IsraelEIN 13-5608399 | Human Services | NY | $1,817,844Small | 75.86 |
| Domestic Abuse ProjectEIN 41-1356278 | Human Services | MN | $1,595,408Small | 76.76 |
| Drisha Institute for Jewish EducationEIN 13-2968932 | Religion | NY | $2,333,063Small | 75.76 |
| Drug Policy AllianceEIN 52-1516692 | Research and Public Policy | NY | $14,612,498Large | 76.86 |
| e3 Partners MinistriesEIN 16-1680978 | Religion | TX | $18,419,441Large | 76.73 |
| Earth Conservation CorpsEIN 52-1683270 | Environment | DC | $350,700Small | 74.09 |
| EarthShareEIN 52-1601960 | Environment | MD | $6,743,365Mid-sized | 76.31 |
| EarthShare CaliforniaEIN 94-2840364 | Environment | CA | $1,349,632Small | 73.23 |
| ECHO of BrandonEIN 59-3051533 | Human Services | FL | $1,536,158Small | 78.95 |
| Education PioneersEIN 77-0602311 | Education | CA | $8,576,514Mid-sized | 72.24 |
| Eisenhower FoundationEIN 48-0634284 | Arts, Culture, Humanities | KS | $2,432,358Small | 77.15 |
| El Museo del BarrioEIN 23-7156720 | Arts, Culture, Humanities | NY | $3,296,157Small | 74.33 |
| ELEM/Youth in Distress in IsraelEIN 13-3171815 | Human Services | NY | $888,375Small | 74.55 |
| Emmaus H.O.M.E.EIN 01-0287624 | Community Development | ME | $1,561,527Small | 72.60 |
| Empowering Lives InternationalEIN 33-0610787 | International | CA | $1,459,122Small | 79.89 |
| Endometriosis AssociationEIN 39-1414754 | Health | WI | $337,741Small | 73.20 |
| endPoverty.orgEIN 54-1371549 | International | VA | $501,476Small | 76.19 |
| Environmental Traveling CompanionsEIN 51-0158789 | Human Services | CA | $1,111,244Small | 78.76 |
| Equal Justice AmericaEIN 13-3708596 | Human and Civil Rights | VA | $1,109,390Small | 73.99 |
| ESCAPE Family Resource CenterEIN 76-0029184 | Human Services | TX | $1,330,222Small | 75.99 |
| Evangelistic Outreach MinistriesEIN 23-7299935 | Religion | OH | $1,273,615Small | 73.32 |
| Everytown for Gun Safety Support FundEIN 26-1598353 | Research and Public Policy | NY | $15,515,941Large | 76.39 |
| EyebeamEIN 13-3952075 | Arts, Culture, Humanities | NY | $1,057,256Small | 73.66 |
| FACE FoundationEIN 13-6165672 | International | NY | $2,861,348Small | 75.38 |
| Fair St. Louis FoundationEIN 43-1218720 | Arts, Culture, Humanities | MO | $2,149,500Small | 76.89 |
| Fairbanks Community Food Bank ServiceEIN 92-0088266 | Human Services | AK | $1,355,270Small | 79.75 |
| Faith and Politics InstituteEIN 52-1759052 | Education | DC | $1,906,591Small | 73.28 |
| Faith Mission of ElkhartEIN 35-6033504 | Human Services | IN | $3,156,064Small | 72.29 |
| Faithful Friends Animal SocietyEIN 51-0410508 | Animals | DE | $2,314,876Small | 75.60 |
| Family CompassEIN 75-2400158 | Human Services | TX | $1,615,254Small | 79.40 |
| Family Equality CouncilEIN 52-1438455 | Human and Civil Rights | NY | $2,186,108Small | 72.01 |
| Family Online Safety InstituteEIN 52-2210323 | Research and Public Policy | DC | $1,588,755Small | 75.34 |
| FCNL Education FundEIN 52-1254489 | Human and Civil Rights | DC | $3,680,702Mid-sized | 78.94 |
| Feminist Majority FoundationEIN 54-1426440 | Human and Civil Rights | VA | $5,626,447Mid-sized | 76.28 |
| Figge Art MuseumEIN 42-6090398 | Arts, Culture, Humanities | IA | $2,865,093Small | 79.93 |
| First Love International MinistriesEIN 36-4423774 | Religion | IL | $3,505,976Mid-sized | 78.53 |
| First PlaceEIN 94-3092447 | Education | WA | $2,652,266Small | 72.57 |
| FixNationEIN 83-0452460 | Animals | CA | $1,275,992Small | 79.61 |
| Flatbush Volunteers of HatzolohEIN 13-3213138 | Health | NY | $1,354,561Small | 73.69 |
| Florida Studio TheatreEIN 23-7362760 | Arts, Culture, Humanities | FL | $7,195,987Mid-sized | 77.97 |
| Florida Wildlife FederationEIN 59-1398265 | Animals | FL | $1,419,414Small | 78.11 |
| FOCASEIN 31-1237943 | International | OH | $800,883Small | 74.94 |
| Focus: HOPEEIN 38-1948285 | Human Services | MI | $24,307,131Large | 79.38 |
| Folksbiene Yiddish TheatreEIN 13-3998872 | Arts, Culture, Humanities | NY | $1,798,228Small | 73.19 |
| Fonkoze USAEIN 52-2022113 | International | DC | $1,800,783Small | 77.87 |
| Food Bank of El Dorado CountyEIN 68-0457594 | Human Services | CA | $3,792,014Mid-sized | 72.71 |
| FoodLink for Tulare CountyEIN 94-2558802 | Human Services | CA | $6,349,821Mid-sized | 77.69 |
| Foundation of Shalom ParkEIN 58-1477833 | Community Development | NC | $3,347,463Small | 79.77 |
| Free Arts NYCEIN 13-3958495 | Human Services | NY | $1,782,779Small | 74.91 |
| Freedom FoundationEIN 94-3136961 | Research and Public Policy | WA | $4,123,043Mid-sized | 78.12 |
| French Institute Alliance FrançaiseEIN 13-1624099 | Arts, Culture, Humanities | NY | $12,169,973Mid-sized | 77.87 |
| Fresno PhilharmonicEIN 94-1309738 | Arts, Culture, Humanities | CA | $1,553,890Small | 71.72 |