| Maccabi USA/Sports for IsraelEIN 13-1810938 | Human Services | PA | $1,938,346Small | 75.73 |
| Macular Degeneration AssociationEIN 27-3025707 | Health | FL | $1,288,362Small | 73.72 |
| Madison Children's MuseumEIN 39-1383497 | Arts, Culture, Humanities | WI | $3,527,783Mid-sized | 75.57 |
| Magic Johnson FoundationEIN 95-4349860 | Health | CA | $1,043,609Small | 79.21 |
| Make-A-Wish Alaska and WashingtonEIN 91-1329433 | Health | WA | $8,859,325Mid-sized | 78.27 |
| Make-A-Wish Foundation of Central New YorkEIN 22-2572086 | Health | NY | $1,700,156Small | 74.64 |
| Make-A-Wish Foundation of Eastern North CarolinaEIN 58-1792140 | Health | NC | $3,320,233Small | 76.86 |
| Make-A-Wish Foundation of Greater Los AngelesEIN 95-4107024 | Health | CA | $6,391,728Mid-sized | 73.82 |
| Make-A-Wish Foundation of Greater Ohio, Kentucky and IndianaEIN 34-1471131 | Health | OH | $10,970,738Mid-sized | 76.24 |
| Make-A-Wish Foundation of Greater VirginiaEIN 54-1429614 | Health | VA | $2,539,494Small | 75.49 |
| Make-A-Wish Foundation of MaineEIN 01-0477512 | Health | ME | $1,270,648Small | 78.38 |
| Make-A-Wish Foundation of MinnesotaEIN 41-1422893 | Health | MN | $4,131,098Mid-sized | 75.53 |
| Make-A-Wish Foundation of Puerto RicoEIN 66-0529880 | Health | PR | $1,177,851Small | 79.71 |
| Make-A-Wish Foundation of South CarolinaEIN 57-0786119 | Health | SC | $3,589,748Mid-sized | 78.99 |
| Make-A-Wish Georgia EIN 58-2146828 | Health | GA | $5,694,610Mid-sized | 76.80 |
| Make-A-Wish Greater Bay AreaEIN 94-2958481 | Health | CA | $8,595,168Mid-sized | 76.79 |
| Make-A-Wish Greater Pennsylvania & West VirginiaEIN 25-1464177 | Health | PA | $8,870,799Mid-sized | 78.47 |
| Make-A-Wish MississippiEIN 64-0730362 | Health | MS | $2,058,583Small | 71.76 |
| Make-A-Wish OklahomaEIN 73-1176743 | Health | OK | $2,337,155Small | 73.64 |
| Make-A-Wish® Missouri & KansasEIN 43-1550697 | Health | MO | $5,144,874Mid-sized | 79.77 |
| Malachi HouseEIN 34-1598707 | Human Services | OH | $1,410,317Small | 77.65 |
| Mama's KitchenEIN 33-0434246 | Human Services | CA | $2,555,149Small | 78.24 |
| Manna Food PantriesEIN 59-2181031 | Human Services | FL | $1,417,371Small | 76.76 |
| Manship TheatreEIN 20-3999559 | Arts, Culture, Humanities | LA | $2,015,238Small | 72.39 |
| March of DimesEIN 13-1846366 | Health | VA | $152,470,269Large | 73.14 |
| Marijuana Policy Project FoundationEIN 52-1975211 | Research and Public Policy | DC | $2,866,841Small | 77.62 |
| Marine Corps Association FoundationEIN 80-0340923 | Human Services | VA | $1,536,917Small | 71.95 |
| Mario Lemieux FoundationEIN 25-1708231 | Health | PA | $1,249,212Small | 78.92 |
| Martha's Village and KitchenEIN 33-0777892 | Human Services | CA | $3,578,914Mid-sized | 71.26 |
| Martha's Vineyard MuseumEIN 04-2160642 | Arts, Culture, Humanities | MA | $2,030,611Small | 73.37 |
| Masonic Medical Research LaboratoryEIN 13-5648611 | Health | NY | $3,253,665Small | 79.52 |
| MASS MoCAEIN 04-3113688 | Arts, Culture, Humanities | MA | $14,296,459Large | 79.41 |
| Massanetta SpringsEIN 54-0505926 | Religion | VA | $1,173,464Small | 74.84 |
| Mastermedia InternationalEIN 33-0104548 | Religion | CA | $1,427,531Small | 70.76 |
| Maui Arts & Cultural CenterEIN 99-0222998 | Arts, Culture, Humanities | HI | $11,032,907Mid-sized | 78.21 |
| Mayor's Alliance for NYC's AnimalsEIN 73-1653635 | Animals | NY | $1,632,234Small | 76.21 |
| Media Matters for AmericaEIN 47-0928008 | Research and Public Policy | DC | $10,867,830Mid-sized | 75.10 |
| Memphis Symphony OrchestraEIN 62-6015885 | Arts, Culture, Humanities | TN | $4,372,302Mid-sized | 79.52 |
| Men of ValorEIN 62-1836815 | Religion | TN | $1,464,289Small | 78.69 |
| MentisEIN 94-1236934 | Health | CA | $2,114,980Small | 72.23 |
| MEOREIN 51-0430002 | Religion | NY | $6,140,357Mid-sized | 78.94 |
| Mercy StreetEIN 45-0536344 | Human Services | TX | $2,077,907Small | 79.92 |
| Metro Hope Recovery MinistriesEIN 41-0705786 | Health | MN | $1,487,004Small | 78.39 |
| Meyer Center for Special ChildrenEIN 57-0361503 | Human Services | SC | $3,157,517Small | 76.42 |
| Michigan Paralyzed Veterans of AmericaEIN 38-6120911 | Human and Civil Rights | MI | $617,011Small | 76.54 |
| Michigan Roundtable for Diversity and InclusionEIN 20-3122770 | Human and Civil Rights | MI | $1,007,165Small | 75.64 |
| Michigan Sheriffs' AssociationEIN 38-2289072 | Human Services | MI | $1,241,599Small | 75.29 |
| Mid-America Science MuseumEIN 20-2129318 | Arts, Culture, Humanities | AR | $1,975,757Small | 78.05 |
| Miles Perret Cancer ServicesEIN 75-3023211 | Health | LA | $1,060,301Small | 77.53 |
| Millennium PromiseEIN 20-3042135 | International | NY | $15,047,799Large | 77.83 |
| Millennium Relief & Development ServicesEIN 76-0574590 | International | TX | $4,170,539Mid-sized | 73.52 |
| MIND Research InstituteEIN 33-0798804 | Education | CA | $29,110,497Large | 79.92 |
| Mingei International MuseumEIN 23-7433357 | Arts, Culture, Humanities | CA | $3,695,785Mid-sized | 79.45 |
| Minnesota Indian Women's Resource CenterEIN 41-1500950 | Human Services | MN | $2,997,682Small | 72.33 |
| MinnPostEIN 26-0573427 | Arts, Culture, Humanities | MN | $1,628,555Small | 77.19 |
| Miracle FlightsEIN 88-0209952 | Health | NV | $3,726,507Mid-sized | 76.73 |
| Mission Medical ClinicEIN 68-0506812 | Health | CO | $384,914Small | 74.88 |
| Mission YearEIN 23-3005514 | Religion | IL | $735,526Small | 74.05 |
| Missionary Aviation Repair CenterEIN 92-0032812 | Religion | AK | $2,511,792Small | 75.64 |
| Missionary Flights InternationalEIN 23-7199063 | Religion | FL | $4,326,147Mid-sized | 74.94 |