| Wolf Trap Foundation for the Performing ArtsEIN 23-7011544 | Arts, Culture, Humanities | VA | $36,931,309Large | 93.20 |
| Wolfpack ClubEIN 56-0650623 | Education | NC | $23,648,439Large | 89.62 |
| Women for Women InternationalEIN 52-1838756 | International | DC | $21,770,442Large | 78.10 |
| Woodlawn FoundationEIN 13-3055729 | Community Development | NY | $17,995,143Large | 93.00 |
| Woodrow Wilson International Center for ScholarsEIN 52-1067541 | Research and Public Policy | DC | $23,108,789Large | 90.34 |
| Woodrow Wilson National Fellowship FoundationEIN 21-0703075 | Education | NJ | $24,168,314Large | 87.50 |
| Woods Hole Oceanographic InstitutionEIN 04-2105850 | Research and Public Policy | MA | $236,368,081Large | 92.95 |
| Word of Life FellowshipEIN 13-5648615 | Religion | NY | $47,064,537Large | 93.21 |
| World EducationEIN 13-1804349 | International | MA | $48,607,047Large | 87.25 |
| World Emergency ReliefEIN 95-4014743 | International | CA | $23,969,741Large | 83.97 |
| World Food Program USAEIN 13-3843435 | International | DC | $17,450,941Large | 85.41 |
| World HelpEIN 54-1615454 | International | VA | $35,916,092Large | 88.43 |
| World Hope InternationalEIN 35-1985485 | International | VA | $19,235,029Large | 92.92 |
| World Medical ReliefEIN 38-1575570 | International | MI | $30,348,974Large | 92.73 |
| World ReliefEIN 23-6393344 | International | MD | $76,751,245Large | 91.20 |
| World Resources InstituteEIN 52-1257057 | Environment | DC | $94,564,842Large | 95.47 |
| World VisionEIN 95-1922279 | International | WA | $999,702,678Large | 86.15 |
| Wounded Warrior ProjectEIN 20-2370934 | Human Services | FL | $231,827,345Large | 86.02 |
| WTTWEIN 36-2246703 | Arts, Culture, Humanities | IL | $44,903,779Large | 83.90 |
| WTVS Detroit Public TelevisionEIN 38-1440200 | Arts, Culture, Humanities | MI | $17,810,033Large | 84.62 |
| WVIA Public MediaEIN 23-1663603 | Arts, Culture, Humanities | PA | $31,292,986Large | 90.71 |
| XPRIZE FoundationEIN 52-1876879 | Research and Public Policy | CA | $36,428,638Large | 78.44 |
| Year UpEIN 04-3534407 | Education | MA | $126,205,361Large | 90.18 |
| Yellowstone ForeverEIN 47-5427975 | Environment | WY | $17,497,778Large | 90.63 |
| Yerba Buena Center for the ArtsEIN 94-3042571 | Arts, Culture, Humanities | CA | $15,060,479Large | 92.91 |
| YMCA and JCC of Greater ToledoEIN 34-4428262 | Human Services | OH | $30,240,839Large | 84.15 |
| YMCA of Capital DistrictEIN 14-1726531 | Human Services | NY | $37,431,981Large | 86.19 |
| YMCA of Central KentuckyEIN 61-0444842 | Human Services | KY | $14,108,069Large | 88.88 |
| YMCA of Central MassachusettsEIN 04-2105885 | Human Services | MA | $18,125,089Large | 89.70 |
| YMCA of Greater BostonEIN 04-2103551 | Human Services | MA | $73,546,098Large | 85.34 |
| YMCA of Greater CharlotteEIN 56-1045299 | Human Services | NC | $87,362,021Large | 91.65 |
| YMCA of Greater Des MoinesEIN 42-0680438 | Human Services | IA | $24,791,877Large | 90.55 |
| YMCA of Greater Grand RapidsEIN 38-1358058 | Human Services | MI | $32,974,563Large | 93.51 |
| YMCA of Greater HoustonEIN 74-1109737 | Human Services | TX | $131,905,393Large | 90.26 |
| YMCA of Greater IndianapolisEIN 35-0868211 | Human Services | IN | $58,412,976Large | 94.34 |
| YMCA of Greater Kansas CityEIN 44-0546002 | Human Services | MO | $48,107,319Large | 87.69 |
| YMCA of Greater New YorkEIN 13-1624228 | Human Services | NY | $190,793,573Large | 93.31 |
| YMCA of Greater OmahaEIN 47-0376586 | Human Services | NE | $20,216,069Large | 93.91 |
| YMCA of Greater PittsburghEIN 25-0969497 | Human Services | PA | $38,361,058Large | 89.27 |
| YMCA of Greater RochesterEIN 16-0743242 | Human Services | NY | $47,133,041Large | 91.42 |
| YMCA of Greater SeattleEIN 91-0482710 | Human Services | WA | $92,328,628Large | 96.15 |
| YMCA of Greater St. PetersburgEIN 59-0624468 | Human Services | FL | $13,559,665Large | 92.28 |
| YMCA of Greater Williamson CountyEIN 74-2206558 | Human Services | TX | $22,253,673Large | 88.74 |
| YMCA of GreenvilleEIN 57-0314424 | Human Services | SC | $22,324,916Large | 84.15 |
| YMCA of HonoluluEIN 99-0073533 | Human Services | HI | $28,641,629Large | 91.90 |
| YMCA of Long IslandEIN 11-1649914 | Human Services | NY | $35,401,188Large | 89.81 |
| YMCA of Metropolitan AtlantaEIN 58-0566253 | Human Services | GA | $106,169,583Large | 93.61 |
| YMCA of Metropolitan ChicagoEIN 36-2179782 | Human Services | IL | $98,359,657Large | 88.33 |
| YMCA of Metropolitan DallasEIN 75-0800696 | Human Services | TX | $58,010,719Large | 93.93 |
| YMCA of Metropolitan DetroitEIN 38-1358055 | Human Services | MI | $37,134,782Large | 85.01 |
| YMCA of Metropolitan Fort WorthEIN 75-0827471 | Human Services | TX | $25,011,179Large | 89.52 |
| YMCA of Metropolitan Los AngelesEIN 95-1644052 | Human Services | CA | $92,647,202Large | 93.13 |
| YMCA of Middle TennesseeEIN 62-0476243 | Human Services | TN | $81,859,823Large | 86.33 |
| YMCA of Orange CountyEIN 95-1644055 | Human Services | CA | $41,178,500Large | 92.23 |
| YMCA of San Diego CountyEIN 95-2039198 | Human Services | CA | $179,969,000Large | 93.64 |
| YMCA of San FranciscoEIN 94-0997140 | Human Services | CA | $86,038,853Large | 89.12 |
| YMCA of the Fox CitiesEIN 39-0806191 | Human Services | WI | $24,652,066Large | 93.42 |
| YMCA of the Pikes Peak RegionEIN 84-0404266 | Human Services | CO | $27,030,879Large | 97.92 |
| YMCA of the RockiesEIN 84-0404913 | Human Services | CO | $35,505,449Large | 91.30 |
| YMCA of the SuncoastEIN 59-0810731 | Human Services | FL | $26,612,638Large | 95.40 |