| Abode ServicesEIN 94-3087060 | Human Services | CA | $39,690,545Large | 94.69 |
| ACCION InternationalEIN 13-2535763 | International | MA | $30,276,113Large | 89.54 |
| Achievement FirstEIN 65-1203744 | Education | CT | $44,360,810Large | 84.01 |
| ACLU Foundation of Southern CaliforniaEIN 95-2673361 | Human and Civil Rights | CA | $15,441,711Large | 89.24 |
| Action Against Hunger USAEIN 13-3327220 | International | NY | $158,347,012Large | 93.98 |
| AcumenEIN 13-4166228 | International | NY | $19,444,682Large | 95.27 |
| Adler PlanetariumEIN 36-6210902 | Arts, Culture, Humanities | IL | $18,818,691Large | 84.58 |
| ADRA InternationalEIN 52-1314847 | International | MD | $58,086,587Large | 88.57 |
| AfricareEIN 23-7116952 | International | DC | $26,832,661Large | 78.62 |
| AFS-USAEIN 39-1711417 | International | NY | $34,083,573Large | 82.12 |
| Aga Khan Foundation, USAEIN 52-1231983 | International | DC | $47,638,836Large | 86.72 |
| Aid for Starving ChildrenEIN 52-1224507 | International | CA | $14,522,855Large | 72.71 |
| Air Force Aid SocietyEIN 54-1797281 | Human Services | VA | $13,528,744Large | 92.39 |
| Akron Community FoundationEIN 34-1087615 | Community Development | OH | $14,391,251Large | 89.24 |
| Akron-Canton Regional FoodbankEIN 34-1369388 | Human Services | OH | $37,914,003Large | 93.94 |
| Alameda County Community Food BankEIN 94-2960297 | Human Services | CA | $73,775,567Large | 97.78 |
| Albright-Knox Art GalleryEIN 16-6001555 | Arts, Culture, Humanities | NY | $18,644,249Large | 90.62 |
| Alex's Lemonade Stand FoundationEIN 56-2496146 | Health | PA | $22,149,112Large | 97.40 |
| All Faiths Food BankEIN 65-0115814 | Human Services | FL | $20,387,573Large | 93.32 |
| Alley TheatreEIN 74-1143076 | Arts, Culture, Humanities | TX | $20,708,905Large | 92.13 |
| Alliance Defending FreedomEIN 54-1660459 | Human and Civil Rights | AZ | $50,304,647Large | 86.60 |
| Aloha United WayEIN 99-0073494 | Community Development | HI | $13,846,084Large | 88.25 |
| Alvin Ailey Dance FoundationEIN 13-2584273 | Arts, Culture, Humanities | NY | $40,518,013Large | 89.43 |
| Alzheimer's AssociationEIN 13-3039601 | Health | IL | $359,577,467Large | 88.70 |
| American Associates, Ben-Gurion University of the NegevEIN 23-7270753 | Education | NY | $47,792,268Large | 95.94 |
| American Association for the Advancement of ScienceEIN 53-0196568 | Research and Public Policy | DC | $107,624,973Large | 87.49 |
| American Ballet TheatreEIN 13-1882106 | Arts, Culture, Humanities | NY | $45,050,346Large | 87.98 |
| American Bar Association Fund for Justice and EducationEIN 36-6110299 | Human and Civil Rights | IL | $74,100,402Large | 82.08 |
| American Battlefield TrustEIN 54-1426643 | Arts, Culture, Humanities | DC | $17,884,556Large | 96.94 |
| American Cancer SocietyEIN 13-1788491 | Health | GA | $879,276,674Large | 80.02 |
| American Civil Liberties Union FoundationEIN 13-6213516 | Human and Civil Rights | NY | $115,464,165Large | 96.66 |
| American Committee for Shaare Zedek Medical Center In JerusalemEIN 13-5645878 | Health | NY | $20,966,439Large | 94.74 |
| American Committee for the Weizmann Institute of ScienceEIN 13-1623886 | Health | NY | $83,439,000Large | 90.96 |
| American Conservatory TheaterEIN 94-6135772 | Arts, Culture, Humanities | CA | $23,341,174Large | 89.42 |
| American Enterprise Institute for Public Policy ResearchEIN 53-0218495 | Research and Public Policy | DC | $55,822,303Large | 87.22 |
| American Family AssociationEIN 64-0607275 | Human and Civil Rights | MS | $18,860,780Large | 90.91 |
| American Film InstituteEIN 52-6072925 | Arts, Culture, Humanities | CA | $30,818,470Large | 80.43 |
| American Foundation for Suicide PreventionEIN 13-3393329 | Health | NY | $23,219,954Large | 89.12 |
| American Friends of IDCEIN 31-1577589 | Education | NY | $19,778,201Large | 86.56 |
| American Friends of Magen David AdomEIN 13-1790719 | Health | NY | $34,622,656Large | 85.50 |
| American Friends of Rabbinical College of TelzstoneEIN 13-3503955 | Religion | NJ | $16,039,770Large | 72.71 |
| American Friends of the Hebrew UniversityEIN 13-1568923 | Education | NY | $60,923,877Large | 87.98 |
| American Friends of the Israel MuseumEIN 23-7182582 | Arts, Culture, Humanities | NY | $17,264,366Large | 85.11 |
| American Friends of The Tel Aviv UniversityEIN 13-1996126 | Education | NY | $36,078,234Large | 93.25 |
| American Friends of Yad EliezerEIN 11-3459952 | Human Services | NJ | $41,944,264Large | 94.69 |
| American Heart AssociationEIN 13-5613797 | Health | TX | $827,059,831Large | 88.07 |
| American HumaneEIN 84-0432950 | Animals | DC | $15,536,919Large | 90.25 |
| American Indian College FundEIN 52-1573446 | Education | CO | $24,590,104Large | 83.67 |
| American Israel Education FoundationEIN 52-1623781 | Education | DC | $56,112,739Large | 81.71 |
| American Jewish Joint Distribution CommitteeEIN 13-1656634 | International | NY | $317,102,196Large | 96.37 |
| American Leprosy MissionsEIN 13-5562163 | International | SC | $14,437,414Large | 87.06 |
| American Lung Association, National HeadquartersEIN 13-1632524 | Health | IL | $39,339,462Large | 83.94 |
| American Museum of Natural HistoryEIN 13-6162659 | Arts, Culture, Humanities | NY | $214,025,292Large | 90.52 |
| American Nicaraguan FoundationEIN 65-0326517 | International | FL | $107,910,005Large | 97.44 |
| American Printing House For The BlindEIN 61-0444640 | Human Services | KY | $18,252,464Large | 84.71 |
| American Red CrossEIN 53-0196605 | Human Services | DC | $3,142,984,060Large | 88.71 |
| American Refugee CommitteeEIN 36-3241033 | International | MN | $45,843,947Large | 96.46 |
| American RiversEIN 23-7305963 | Environment | DC | $14,465,768Large | 86.37 |
| American Society for the Defense of Tradition, Family and PropertyEIN 23-7325778 | Religion | PA | $14,478,944Large | 78.93 |
| American Society for the Prevention of Cruelty to AnimalsEIN 13-1623829 | Animals | NY | $208,434,628Large | 83.75 |