| American Society for Yad VashemEIN 13-3106768 | Arts, Culture, Humanities | NY | $16,168,788Large | 92.22 |
| American Technion SocietyEIN 13-0434195 | Education | NY | $102,913,014Large | 93.52 |
| Americans For Prosperity FoundationEIN 52-1527294 | Human and Civil Rights | VA | $23,028,942Large | 81.16 |
| Americans for the ArtsEIN 52-1996467 | Arts, Culture, Humanities | DC | $16,084,664Large | 91.45 |
| AmericaresEIN 06-1008595 | International | CT | $1,927,303,882Large | 97.87 |
| Amherst H. Wilder FoundationEIN 41-0693889 | Human Services | MN | $45,788,233Large | 86.30 |
| Amnesty International USAEIN 52-0851555 | International | NY | $39,020,245Large | 89.40 |
| Andrew Wommack MinistriesEIN 84-0780017 | Religion | CO | $47,946,843Large | 96.32 |
| AneraEIN 52-0882226 | International | DC | $68,483,582Large | 92.56 |
| Animal Humane SocietyEIN 41-0693842 | Animals | MN | $18,408,428Large | 87.42 |
| Anita Borg InstituteEIN 77-0480427 | Education | CA | $19,390,962Large | 92.66 |
| Answers in GenesisEIN 33-0596423 | Religion | KY | $22,980,427Large | 76.50 |
| Anti-Defamation LeagueEIN 13-1818723 | Human and Civil Rights | NY | $63,917,573Large | 78.65 |
| Apartment LifeEIN 75-2868621 | Community Development | TX | $13,791,829Large | 85.68 |
| Apollo Theater FoundationEIN 13-3630066 | Arts, Culture, Humanities | NY | $16,923,763Large | 89.07 |
| Appalachian Mountain ClubEIN 04-6001677 | Environment | MA | $31,787,810Large | 95.87 |
| Aquarium of the PacificEIN 33-0532354 | Animals | CA | $31,141,128Large | 91.67 |
| Arizona Christian School Tuition OrganizationEIN 86-0931047 | Education | AZ | $19,281,533Large | 91.05 |
| Arizona Community FoundationEIN 86-0348306 | Community Development | AZ | $67,913,276Large | 92.98 |
| Arizona Humane SocietyEIN 86-0135567 | Animals | AZ | $18,373,050Large | 90.64 |
| Arkansas FoodbankEIN 71-0596734 | Human Services | AR | $43,348,876Large | 90.22 |
| Armed Services YMCAEIN 36-3274346 | Human Services | VA | $22,350,334Large | 93.12 |
| Armenian General Benevolent UnionEIN 13-5600421 | International | NY | $23,318,407Large | 85.03 |
| Army Emergency ReliefEIN 53-0196552 | Human Services | VA | $28,198,705Large | 93.98 |
| Artis—NaplesEIN 59-2322926 | Arts, Culture, Humanities | FL | $30,005,832Large | 94.36 |
| Arts & Science CouncilEIN 56-0693436 | Arts, Culture, Humanities | NC | $14,255,071Large | 84.22 |
| Artspace ProjectsEIN 41-1350071 | Arts, Culture, Humanities | MN | $35,730,629Large | 89.48 |
| ArtsWaveEIN 31-0537138 | Arts, Culture, Humanities | OH | $14,978,630Large | 84.38 |
| AshokaEIN 51-0255908 | International | VA | $20,517,822Large | 86.51 |
| Asia SocietyEIN 13-3234632 | International | NY | $31,773,102Large | 85.53 |
| Asian & Pacific Islander American Scholarship FundEIN 57-1192973 | Education | DC | $20,152,919Large | 89.92 |
| Asian Americans Advancing Justice Los AngelesEIN 95-3854152 | Human and Civil Rights | CA | $13,833,697Large | 92.02 |
| Aspen Music Festival and SchoolEIN 84-0445087 | Arts, Culture, Humanities | CO | $19,427,693Large | 91.83 |
| Association to Benefit ChildrenEIN 13-3303089 | Human Services | NY | $18,345,443Large | 96.61 |
| ASU FoundationEIN 86-6051042 | Education | AZ | $123,638,324Large | 97.70 |
| Atlanta Community Food BankEIN 58-1376648 | Human Services | GA | $144,693,855Large | 90.58 |
| Atlanta MissionEIN 58-0572430 | Human Services | GA | $17,707,982Large | 85.25 |
| Audubon Nature InstituteEIN 51-0157624 | Animals | LA | $35,617,671Large | 86.02 |
| Austin Community FoundationEIN 74-1934031 | Community Development | TX | $28,998,360Large | 91.33 |
| Autism SpeaksEIN 20-2329938 | Health | NY | $42,861,302Large | 80.10 |
| AwanaEIN 36-2428692 | Religion | IL | $31,541,865Large | 81.37 |
| Baltimore Community FoundationEIN 23-7180620 | Community Development | MD | $29,684,832Large | 90.54 |
| Baltimore Symphony OrchestraEIN 52-0629696 | Arts, Culture, Humanities | MD | $27,938,029Large | 80.71 |
| Baptist Children's Homes of North CarolinaEIN 56-0547499 | Human Services | NC | $25,600,894Large | 96.21 |
| Baptist Medical & Dental Mission InternationalEIN 64-0811705 | International | MS | $14,124,395Large | 93.34 |
| Barnabas FoundationEIN 36-2904503 | Community Development | IL | $67,443,319Large | 91.36 |
| Baton Rouge Area FoundationEIN 72-6030391 | Community Development | LA | $39,996,274Large | 93.08 |
| BBYOEIN 31-1794932 | Religion | DC | $31,255,555Large | 85.97 |
| BELL (Building Educated Leaders for Life)EIN 04-3182053 | Education | MA | $16,560,910Large | 88.19 |
| Bender Jewish Community Center of Greater WashingtonEIN 53-0205921 | Human Services | MD | $14,681,556Large | 92.74 |
| Bergen County's United WayEIN 22-6028959 | Community Development | NJ | $17,834,641Large | 89.86 |
| Berkeley Repertory TheatreEIN 94-1679756 | Arts, Culture, Humanities | CA | $20,346,600Large | 94.42 |
| Bermuda Institute of Ocean SciencesEIN 06-0706038 | Research and Public Policy | NY | $15,876,165Large | 94.04 |
| Best Buddies InternationalEIN 52-1614576 | Human Services | FL | $26,289,255Large | 87.85 |
| Bethesda Lutheran CommunitiesEIN 39-0806446 | Human Services | WI | $150,208,423Large | 84.39 |
| Big Brothers Big Sisters of AmericaEIN 23-1365190 | Human Services | FL | $22,384,996Large | 89.33 |
| Big Shoulders FundEIN 36-3490557 | Education | IL | $18,807,655Large | 98.64 |
| Birch Community ServicesEIN 93-1186020 | Human Services | OR | $15,057,816Large | 92.24 |
| Birthright Israel FoundationEIN 13-4092050 | Education | NY | $98,592,432Large | 90.74 |
| Blue Ridge Area Food BankEIN 52-1202644 | Human Services | VA | $47,554,040Large | 94.26 |