| Catholic Charities of St. Paul and MinneapolisEIN 41-1302487 | Human Services | MN | $50,683,237Large | 92.01 |
| Catholic Charities of the Archdiocese of Galveston-HoustonEIN 74-1109733 | Human Services | TX | $38,475,867Large | 93.20 |
| Catholic Charities of the Diocese of Santa RosaEIN 94-2479393 | Human Services | CA | $13,533,849Large | 90.17 |
| Catholic Charities Southwestern OhioEIN 31-0536968 | Human Services | OH | $16,836,807Large | 87.22 |
| Catholic Charities, Archdiocese of DenverEIN 84-0686679 | Human Services | CO | $25,590,589Large | 95.04 |
| Catholic Community FoundationEIN 34-1908579 | Human Services | OH | $18,059,323Large | 80.25 |
| Catholic Education ArizonaEIN 86-0937587 | Education | AZ | $18,380,089Large | 83.46 |
| Catholic Health Initiatives Colorado FoundationEIN 84-0902211 | Health | CO | $24,601,571Large | 81.46 |
| Catholic Medical Mission BoardEIN 13-5602319 | International | NY | $581,681,284Large | 97.87 |
| Catholic Near East Welfare Association (CNEWA)EIN 13-1623929 | Religion | NY | $25,303,965Large | 95.54 |
| CDC FoundationEIN 58-2106707 | Health | GA | $91,221,521Large | 98.23 |
| Cenikor FoundationEIN 76-0031861 | Health | TX | $20,080,690Large | 93.59 |
| Center for American ProgressEIN 30-0126510 | Research and Public Policy | DC | $46,765,901Large | 91.15 |
| Center for Biological Diversity EIN 27-3943866 | Environment | AZ | $17,996,339Large | 97.87 |
| Center for Community ChangeEIN 52-0888113 | Community Development | DC | $17,680,880Large | 88.05 |
| Center for Global DevelopmentEIN 52-2351337 | International | DC | $15,025,801Large | 92.81 |
| Center for Reproductive RightsEIN 13-3669731 | Human and Civil Rights | NY | $24,884,918Large | 93.94 |
| Center on Budget and Policy PrioritiesEIN 52-1234565 | Research and Public Policy | DC | $28,721,352Large | 90.53 |
| Central California Food BankEIN 77-0320851 | Human Services | CA | $65,008,490Large | 94.67 |
| Central Florida YMCAEIN 59-0624430 | Human Services | FL | $59,588,094Large | 85.96 |
| Central Illinois FoodbankEIN 37-1106465 | Human Services | IL | $18,256,991Large | 92.92 |
| Central Indiana Community FoundationEIN 35-1793680 | Community Development | IN | $27,466,633Large | 91.42 |
| Central New York Community FoundationEIN 15-0626910 | Community Development | NY | $22,768,461Large | 97.89 |
| Central Park ConservancyEIN 13-3022855 | Environment | NY | $72,425,618Large | 94.20 |
| Central Pennsylvania Food BankEIN 23-2202250 | Human Services | PA | $83,599,202Large | 98.23 |
| Central Texas Food BankEIN 74-2217350 | Human Services | TX | $88,983,352Large | 96.46 |
| Central Union MissionEIN 53-0218650 | Human Services | DC | $16,421,755Large | 89.86 |
| CeresEIN 22-3053747 | Environment | MA | $14,937,631Large | 96.52 |
| Chai LifelineEIN 11-2940331 | Human Services | NY | $19,233,028Large | 86.18 |
| Channel Islands YMCAEIN 95-1643379 | Human Services | CA | $18,458,636Large | 90.64 |
| Channel One Regional Food BankEIN 41-1379713 | Human Services | MN | $15,937,633Large | 92.05 |
| Chapman PartnershipEIN 65-0425069 | Human Services | FL | $16,277,068Large | 95.11 |
| charity: waterEIN 22-3936753 | International | NY | $35,902,241Large | 91.16 |
| Chattanooga Area Food BankEIN 62-0867645 | Human Services | TN | $28,411,914Large | 93.49 |
| Cheyenne Mountain ZooEIN 84-0407039 | Animals | CO | $13,534,283Large | 92.94 |
| Chicago Botanic GardenEIN 36-2225482 | Environment | IL | $48,755,048Large | 88.85 |
| Chicago History MuseumEIN 36-2167004 | Arts, Culture, Humanities | IL | $16,954,477Large | 77.98 |
| Chicago Public MediaEIN 36-3687394 | Arts, Culture, Humanities | IL | $24,050,416Large | 83.37 |
| Chicago Shakespeare TheaterEIN 36-3467607 | Arts, Culture, Humanities | IL | $16,536,820Large | 90.52 |
| Chicago Symphony OrchestraEIN 36-2167823 | Arts, Culture, Humanities | IL | $79,669,618Large | 83.61 |
| Chicago Zoological SocietyEIN 36-2167016 | Animals | IL | $73,409,870Large | 86.85 |
| Child Crisis ArizonaEIN 86-0324144 | Human Services | AZ | $13,582,767Large | 97.39 |
| Child Evangelism FellowshipEIN 38-6091187 | Religion | MO | $16,705,310Large | 82.62 |
| Child Mind InstituteEIN 80-0478843 | Health | NY | $14,159,225Large | 91.25 |
| ChildFund InternationalEIN 54-0536100 | International | VA | $198,375,886Large | 81.59 |
| ChildhelpEIN 95-2884608 | Human Services | AZ | $39,767,034Large | 85.77 |
| Children InternationalEIN 44-6005794 | International | MO | $137,699,672Large | 87.62 |
| Children's AidEIN 13-5562191 | Human Services | NY | $130,688,819Large | 86.93 |
| Children's Defense FundEIN 52-0895622 | Human Services | DC | $19,117,496Large | 84.09 |
| Children's Home Society of FloridaEIN 59-0192430 | Human Services | FL | $117,824,708Large | 85.01 |
| Children's Hospital Guild AssociationEIN 91-1394056 | Health | WA | $16,109,649Large | 86.84 |
| Children's Hospital of Wisconsin FoundationEIN 39-1500075 | Health | WI | $30,317,764Large | 87.65 |
| Children's Hunger FundEIN 95-4335462 | International | CA | $77,135,389Large | 95.47 |
| Children's Literacy InitiativeEIN 23-2515768 | Education | PA | $25,103,055Large | 91.16 |
| Children's Miracle Network HospitalsEIN 87-0387205 | Health | UT | $44,054,370Large | 87.12 |
| Children's Scholarship FundEIN 13-4002189 | Education | NY | $22,111,290Large | 89.39 |
| CHN Housing PartnersEIN 34-1346763 | Community Development | OH | $29,894,702Large | 85.57 |
| CHOC FoundationEIN 95-6097416 | Health | CA | $37,904,682Large | 91.07 |
| Christ for all NationsEIN 94-2742504 | Religion | FL | $17,579,946Large | 91.28 |
| Christian Aid MinistriesEIN 34-1344364 | International | OH | $122,451,700Large | 87.02 |