| Christian Appalachian ProjectEIN 61-0661137 | Human Services | KY | $96,797,178Large | 91.92 |
| Christian Blind Mission InternationalEIN 36-2959883 | International | SC | $158,563,714Large | 90.00 |
| Christian Relief Services CharitiesEIN 91-1937903 | Human Services | VA | $48,136,468Large | 90.58 |
| ChrysalisEIN 95-3972624 | Human Services | CA | $18,364,058Large | 92.92 |
| Church Health EIN 58-1716113 | Health | TN | $20,797,265Large | 94.58 |
| Church World ServiceEIN 13-4080201 | International | IN | $65,527,734Large | 83.94 |
| Cincinnati Art MuseumEIN 31-0536653 | Arts, Culture, Humanities | OH | $14,729,738Large | 94.04 |
| Cincinnati Symphony OrchestraEIN 31-0537080 | Arts, Culture, Humanities | OH | $31,381,796Large | 91.96 |
| Cincinnati Zoo & Botanical GardenEIN 31-0537171 | Animals | OH | $43,193,066Large | 90.73 |
| CIS Development FoundationEIN 22-3304404 | International | NJ | $41,239,855Large | 83.73 |
| CitiHope Relief & DevelopmentEIN 13-2907656 | International | NY | $148,169,686Large | 95.05 |
| Citizen SchoolsEIN 04-3259160 | Education | MA | $20,565,491Large | 85.00 |
| City HarvestEIN 13-3170676 | Human Services | NY | $123,039,582Large | 87.08 |
| City Parks FoundationEIN 13-3561657 | Environment | NY | $20,273,100Large | 94.26 |
| City Union Mission, Inc.EIN 44-6005481 | Human Services | MO | $14,140,675Large | 95.87 |
| City YearEIN 22-2882549 | Human Services | MA | $148,415,766Large | 92.67 |
| Citymeals-on-WheelsEIN 13-3634381 | Human Services | NY | $20,441,242Large | 90.36 |
| CitySquareEIN 75-2332948 | Human Services | TX | $20,653,887Large | 92.74 |
| CityteamEIN 94-1501265 | Human Services | CA | $26,665,848Large | 87.76 |
| Clearwater Marine AquariumEIN 59-2086737 | Animals | FL | $15,652,675Large | 95.87 |
| Cleveland Museum of Natural HistoryEIN 34-0714338 | Arts, Culture, Humanities | OH | $18,722,320Large | 90.29 |
| Coastal Bend Food Bank EIN 74-2234089 | Human Services | TX | $16,183,493Large | 88.35 |
| Coastal Conservation AssociationEIN 74-1984482 | Environment | TX | $13,776,533Large | 81.37 |
| Cold Spring Harbor LaboratoryEIN 11-2013303 | Research and Public Policy | NY | $147,631,524Large | 92.80 |
| College PossibleEIN 41-1968798 | Education | MN | $16,391,039Large | 91.38 |
| College TrackEIN 94-3279613 | Education | CA | $18,429,592Large | 96.15 |
| Colonial Williamsburg FoundationEIN 54-0505888 | Arts, Culture, Humanities | VA | $138,893,757Large | 84.28 |
| Colorado Public RadioEIN 74-2324052 | Arts, Culture, Humanities | CO | $17,648,179Large | 95.44 |
| Columbus Museum of ArtEIN 31-4379447 | Arts, Culture, Humanities | OH | $13,970,682Large | 91.73 |
| Columbus Zoo and AquariumEIN 31-4390844 | Animals | OH | $71,124,051Large | 92.24 |
| Combined Jewish PhilanthropiesEIN 04-2103559 | Community Development | MA | $166,682,869Large | 94.56 |
| Comic Relief Inc.EIN 01-0885377 | Human Services | NY | $91,909,090Large | 89.02 |
| Commission To Every NationEIN 74-2730294 | Religion | TX | $17,045,573Large | 96.46 |
| Common Sense MediaEIN 41-2024986 | Arts, Culture, Humanities | CA | $22,906,362Large | 93.91 |
| CommonBond CommunitiesEIN 41-1260469 | Community Development | MN | $13,518,416Large | 92.27 |
| Communities Foundation of TexasEIN 75-0964565 | Community Development | TX | $129,532,950Large | 91.42 |
| Communities In Schools National OfficeEIN 58-1289174 | Education | VA | $20,927,294Large | 90.78 |
| Community Food Bank of Eastern OklahomaEIN 73-1184980 | Human Services | OK | $43,371,982Large | 96.27 |
| Community Food Bank of Southern ArizonaEIN 51-0192519 | Human Services | AZ | $111,072,094Large | 96.46 |
| Community Food ShareEIN 74-2227731 | Human Services | CO | $20,601,342Large | 98.39 |
| Community FoodBank of New JerseyEIN 22-2423882 | Human Services | NJ | $109,440,055Large | 93.22 |
| Community Foundation for Greater BuffaloEIN 22-2743917 | Community Development | NY | $24,816,523Large | 95.13 |
| Community Foundation for Southeast MichiganEIN 38-2530980 | Community Development | MI | $63,998,200Large | 92.29 |
| Community Foundation for the Fox Valley RegionEIN 39-1548450 | Community Development | WI | $25,089,419Large | 91.93 |
| Community Foundation of Greater MemphisEIN 58-1723645 | Community Development | TN | $168,373,829Large | 94.34 |
| Community Foundation of Middle TennesseeEIN 62-1471789 | Community Development | TN | $53,539,306Large | 93.67 |
| Community Foundation of New JerseyEIN 22-2281783 | Community Development | NJ | $61,663,141Large | 98.03 |
| Community Foundation Sonoma CountyEIN 68-0003212 | Community Development | CA | $17,422,939Large | 91.20 |
| Community Harvest Food Bank of Northeast IndianaEIN 31-1100607 | Human Services | IN | $22,984,466Large | 93.24 |
| Community Service Society of New YorkEIN 13-5562202 | Human Services | NY | $33,421,644Large | 91.66 |
| Compassion & ChoicesEIN 84-1328829 | Human and Civil Rights | CO | $14,808,739Large | 96.56 |
| Compassion InternationalEIN 36-2423707 | International | CO | $861,733,317Large | 84.76 |
| Concern Worldwide US, Inc.EIN 13-3712030 | International | NY | $42,569,967Large | 90.91 |
| Connecticut Food BankEIN 06-1063025 | Human Services | CT | $48,839,774Large | 91.03 |
| Connecticut Public BroadcastingEIN 06-0758938 | Arts, Culture, Humanities | CT | $22,123,694Large | 85.22 |
| Conquer Cancer Foundation of the American Society of Clinical OncologyEIN 31-1667995 | Health | VA | $27,245,874Large | 95.85 |
| Conservation InternationalEIN 52-1497470 | Environment | VA | $149,806,220Large | 95.88 |
| Consortium for Graduate Study in ManagementEIN 43-0962198 | Education | MO | $36,743,080Large | 84.82 |
| Convoy of HopeEIN 68-0051386 | Human Services | MO | $157,932,066Large | 96.46 |
| Corporation for Supportive HousingEIN 13-3600232 | Community Development | NY | $38,140,011Large | 94.67 |