| COSI Center of Science and IndustryEIN 31-4383802 | Arts, Culture, Humanities | OH | $17,916,053Large | 85.79 |
| Council of Independent CollegesEIN 01-6004776 | Education | DC | $13,706,554Large | 87.42 |
| Council on Foreign RelationsEIN 13-1628168 | International | NY | $69,262,800Large | 87.81 |
| Country Music FoundationEIN 62-0753887 | Arts, Culture, Humanities | TN | $31,719,231Large | 80.61 |
| Covenant House New YorkEIN 13-3076376 | Human Services | NY | $21,165,223Large | 88.04 |
| Cradles to CrayonsEIN 04-3584367 | Human Services | MA | $15,682,610Large | 96.46 |
| Crisis Assistance MinistryEIN 56-1416719 | Human Services | NC | $15,189,615Large | 89.39 |
| CRISTA MinistriesEIN 91-6012289 | Religion | WA | $114,902,453Large | 92.22 |
| Crohn's & Colitis Foundation EIN 13-6193105 | Health | NY | $75,664,404Large | 88.16 |
| Crossnore SchoolEIN 56-0567980 | Human Services | NC | $15,549,420Large | 94.62 |
| Cure Alzheimer's FundEIN 52-2396428 | Health | MA | $18,999,554Large | 98.23 |
| CURE InternationalEIN 58-2248383 | International | MI | $62,536,689Large | 94.69 |
| D.C. Central KitchenEIN 52-1584936 | Human Services | DC | $16,677,394Large | 92.92 |
| Dallas Area Habitat for HumanityEIN 75-2097161 | Community Development | TX | $20,413,100Large | 91.70 |
| Dallas Museum of ArtEIN 75-0808774 | Arts, Culture, Humanities | TX | $28,537,301Large | 81.64 |
| Damon Runyon Cancer Research FoundationEIN 13-1933825 | Health | NY | $19,596,662Large | 94.78 |
| Dana-Farber Cancer InstituteEIN 04-2263040 | Health | MA | $1,528,239,259Large | 92.74 |
| Dare to Care Food BankEIN 23-7345952 | Human Services | KY | $43,226,997Large | 97.26 |
| Daughters of the American RevolutionEIN 53-0205923 | Arts, Culture, Humanities | DC | $16,267,791Large | 75.61 |
| Dave Thomas Foundation for AdoptionEIN 31-1356151 | Human Services | OH | $24,102,108Large | 96.29 |
| Delancey Street FoundationEIN 23-7102690 | Human Services | CA | $102,283,206Large | 91.45 |
| Delivering GoodEIN 13-3300271 | Human Services | NY | $217,120,707Large | 94.69 |
| Denver Art MuseumEIN 84-6038240 | Arts, Culture, Humanities | CO | $41,996,799Large | 91.19 |
| Denver Botanic GardensEIN 84-0440359 | Environment | CO | $21,365,255Large | 90.84 |
| Denver Center for the Performing ArtsEIN 84-0407760 | Arts, Culture, Humanities | CO | $52,094,113Large | 83.04 |
| Denver Rescue MissionEIN 84-6038762 | Human Services | CO | $32,935,233Large | 89.43 |
| Denver Zoological FoundationEIN 84-0502539 | Animals | CO | $42,618,070Large | 88.57 |
| Desert AIDS ProjectEIN 33-0068583 | Health | CA | $32,043,691Large | 95.02 |
| Desert Botanical GardenEIN 86-0136925 | Environment | AZ | $15,606,893Large | 83.88 |
| Detroit Rescue Mission MinistriesEIN 38-1459371 | Human Services | MI | $20,146,632Large | 91.70 |
| Detroit Symphony OrchestraEIN 38-1385132 | Arts, Culture, Humanities | MI | $36,345,989Large | 92.06 |
| Detroit Zoological SocietyEIN 38-6027356 | Animals | MI | $40,691,390Large | 92.44 |
| Dia Art FoundationEIN 23-7397946 | Arts, Culture, Humanities | NY | $16,546,314Large | 89.01 |
| Direct ReliefEIN 95-1831116 | International | CA | $1,008,907,873Large | 100.00 |
| Disabled Veterans National FoundationEIN 26-1446183 | Human Services | MD | $29,301,117Large | 29.25 |
| Discovery PlaceEIN 56-0529944 | Arts, Culture, Humanities | NC | $15,241,959Large | 91.91 |
| DKT InternationalEIN 58-1593137 | International | DC | $199,519,332Large | 88.81 |
| Doctors Without Borders, USAEIN 13-3433452 | International | NY | $420,595,919Large | 94.74 |
| Doheny Eye InstituteEIN 95-2916590 | Health | CA | $23,595,251Large | 82.85 |
| Dollar Energy FundEIN 25-1442933 | Human Services | PA | $15,557,633Large | 91.16 |
| DonorsChoose.orgEIN 13-4129457 | Education | NY | $102,666,357Large | 96.66 |
| DREAMEIN 13-4025290 | Human Services | NY | $15,172,457Large | 91.42 |
| Dress for Success WorldwideEIN 13-4040377 | Human Services | NY | $22,405,064Large | 91.40 |
| Drug Policy AllianceEIN 52-1516692 | Research and Public Policy | NY | $14,612,498Large | 76.86 |
| Dumb Friends LeagueEIN 84-0405254 | Animals | CO | $18,015,992Large | 90.47 |
| e3 Partners MinistriesEIN 16-1680978 | Religion | TX | $18,419,441Large | 76.73 |
| EarthjusticeEIN 94-1730465 | Environment | CA | $51,564,754Large | 94.85 |
| East Bay Community FoundationEIN 94-6070996 | Community Development | CA | $29,631,756Large | 87.62 |
| East Lake FoundationEIN 58-2204306 | Community Development | GA | $16,362,404Large | 89.24 |
| East Side HouseEIN 13-1623989 | Human Services | NY | $22,000,963Large | 98.23 |
| East Texas Food BankEIN 75-2222686 | Human Services | TX | $32,138,551Large | 95.28 |
| East-West Ministries InternationalEIN 75-2486132 | Religion | TX | $17,806,811Large | 93.10 |
| Easter Seals Capper FoundationEIN 48-0543745 | Human Services | KS | $13,693,269Large | 92.92 |
| Eastern Illinois FoodbankEIN 37-1130252 | Human Services | IL | $19,826,056Large | 95.05 |
| EcoHealth AllianceEIN 31-1726494 | Animals | NY | $13,652,783Large | 92.92 |
| Educational Media FoundationEIN 94-2816342 | Religion | CA | $112,676,029Large | 94.34 |
| Elizabeth Glaser Pediatric AIDS FoundationEIN 95-4191698 | Health | DC | $180,014,269Large | 88.29 |
| Emergency Food NetworkEIN 94-3131776 | Human Services | WA | $23,422,846Large | 91.78 |
| EnactusEIN 74-2148471 | Education | MO | $14,501,666Large | 82.89 |
| Energy Outreach ColoradoEIN 74-2543881 | Human Services | CO | $25,022,578Large | 90.82 |