| Safe PassageEIN 01-0532835 | International | ME | $2,200,573Small | 84.19 |
| Safe Place of the Permian BasinEIN 75-1657264 | Human Services | TX | $1,809,322Small | 85.44 |
| SAFEchildEIN 56-1817816 | Human Services | NC | $1,394,963Small | 92.22 |
| SafeHouse CenterEIN 38-2121751 | Human Services | MI | $2,244,935Small | 93.08 |
| SafeHouse OutreachEIN 58-2130936 | Human Services | GA | $966,006Small | 78.67 |
| Saginaw Art MuseumEIN 38-1280546 | Arts, Culture, Humanities | MI | $811,425Small | 82.71 |
| Salina Area United WayEIN 48-0573808 | Community Development | KS | $855,591Small | 82.71 |
| Salina Rescue MissionEIN 48-0944358 | Human Services | KS | $1,309,100Small | 93.77 |
| Samaritan Center for Young Boys & FamiliesEIN 59-1373247 | Human Services | FL | $503,874Small | 73.91 |
| Samaritan InnsEIN 52-1474935 | Human Services | DC | $3,384,447Small | 97.66 |
| Samaritan MinistriesEIN 56-1490019 | Human Services | NC | $1,372,704Small | 87.50 |
| Samaritan Ministry of Greater WashingtonEIN 52-1434143 | Human Services | DC | $1,171,383Small | 92.80 |
| SamaritansEIN 04-2643466 | Health | MA | $1,950,989Small | 82.85 |
| Samuel Waxman Cancer Research FoundationEIN 13-3020943 | Health | NY | $2,301,162Small | 78.41 |
| San Antonio Botanical Garden SocietyEIN 74-2178792 | Environment | TX | $2,825,220Small | 88.42 |
| San Diego Botanic GardenEIN 95-6120581 | Environment | CA | $2,978,807Small | 84.42 |
| San Diego Center for the BlindEIN 95-3076944 | Health | CA | $1,712,478Small | 94.05 |
| San Diego Children's Discovery MuseumEIN 33-0912735 | Arts, Culture, Humanities | CA | $1,516,896Small | 91.02 |
| San Diego CoastkeeperEIN 33-0647946 | Environment | CA | $668,734Small | 78.81 |
| San Diego History CenterEIN 95-1728991 | Arts, Culture, Humanities | CA | $2,750,444Small | 80.20 |
| San Diego River Park FoundationEIN 01-0565671 | Environment | CA | $939,333Small | 85.40 |
| San Francisco BaykeeperEIN 68-0120240 | Environment | CA | $1,512,332Small | 84.75 |
| San Francisco CASAEIN 94-3039028 | Human Services | CA | $1,314,905Small | 92.51 |
| San Francisco Education FundEIN 94-1592822 | Education | CA | $2,439,113Small | 97.17 |
| San Francisco Gay Men's ChorusEIN 94-2576101 | Arts, Culture, Humanities | CA | $2,592,794Small | 79.95 |
| San Francisco Girls ChorusEIN 94-2711726 | Education | CA | $1,869,096Small | 79.41 |
| San Francisco PerformancesEIN 94-2600147 | Arts, Culture, Humanities | CA | $3,233,850Small | 88.79 |
| San Joaquin River Parkway and Conservation TrustEIN 77-0196692 | Environment | CA | $1,749,897Small | 90.56 |
| San Luis Obispo SymphonyEIN 95-2493144 | Arts, Culture, Humanities | CA | $1,134,318Small | 76.61 |
| Sandusky State TheaterEIN 34-1568622 | Arts, Culture, Humanities | OH | $1,008,488Small | 72.56 |
| Sanibel-Captiva Conservation FoundationEIN 59-1205087 | Environment | FL | $3,095,476Small | 90.45 |
| Sankara Nethralaya Om TrustEIN 52-1611548 | Health | MD | $912,982Small | 86.07 |
| Santa Barbara Historical MuseumEIN 95-6005796 | Arts, Culture, Humanities | CA | $1,580,925Small | 85.57 |
| Santa Barbara Opera AssociationEIN 77-0347413 | Arts, Culture, Humanities | CA | $1,636,380Small | 72.64 |
| Santa Barbara Rescue MissionEIN 95-6134271 | Human Services | CA | $2,671,065Small | 83.81 |
| Santa Barbara Symphony Orchestra AssociationEIN 95-2104089 | Arts, Culture, Humanities | CA | $3,200,471Small | 87.97 |
| Santa Cruz Museum of Art and History at the McPherson CenterEIN 94-2718861 | Arts, Culture, Humanities | CA | $1,864,470Small | 92.02 |
| Santa Fe Art InstituteEIN 85-0404277 | Arts, Culture, Humanities | NM | $775,980Small | 83.63 |
| Santa Fe Chamber Music FestivalEIN 85-0224461 | Arts, Culture, Humanities | NM | $2,360,562Small | 82.12 |
| Sarah's CircleEIN 36-3043662 | Human Services | IL | $2,023,629Small | 92.21 |
| Sarcoma Foundation of AmericaEIN 52-2275294 | Health | MD | $1,903,735Small | 94.74 |
| Savannah Jewish FederationEIN 58-0566231 | Community Development | GA | $2,108,440Small | 94.04 |
| Save a Child's Heart FoundationEIN 52-1783323 | International | MD | $2,474,430Small | 96.16 |
| Save Our Wild SalmonEIN 91-1673170 | Animals | WA | $219,201Small | 77.10 |
| Save Our YouthEIN 84-1295393 | Human Services | CO | $1,378,599Small | 72.08 |
| Save the Manatee ClubEIN 59-3131709 | Animals | FL | $1,168,356Small | 90.23 |
| SAVE, A Friend to Homeless AnimalsEIN 22-6082741 | Animals | NJ | $1,313,195Small | 90.29 |
| Save-A-Pet Adoption CenterEIN 23-7304570 | Animals | IL | $1,746,870Small | 91.33 |
| Schlitz Audubon Nature CenterEIN 39-1231819 | Environment | WI | $2,897,570Small | 90.69 |
| School on WheelsEIN 95-4422640 | Education | CA | $2,114,477Small | 95.47 |
| Schoolseed FoundationEIN 26-4477567 | Education | TN | $2,998,033Small | 88.14 |
| Sci-PortEIN 72-1136273 | Arts, Culture, Humanities | LA | $2,808,564Small | 65.56 |
| Science CentralEIN 31-1032583 | Arts, Culture, Humanities | IN | $1,724,835Small | 88.58 |
| Science Friday InitiativeEIN 13-4252173 | Arts, Culture, Humanities | NY | $2,963,802Small | 92.22 |
| Science Museum of Western VirginiaEIN 54-1023953 | Arts, Culture, Humanities | VA | $871,912Small | 88.97 |
| Scleroderma Research FoundationEIN 68-0087234 | Health | CA | $2,527,636Small | 97.17 |
| Scottsdale League for the ArtsEIN 94-2562752 | Arts, Culture, Humanities | AZ | $418,735Small | 60.53 |
| Scripture Memory Mountain MissionEIN 61-6034476 | Religion | KY | $1,260,347Small | 64.88 |
| Scripture Union/USAEIN 25-1228715 | Religion | PA | $1,673,692Small | 83.74 |
| Sea Turtle ConservancyEIN 59-6151069 | Animals | FL | $3,339,353Small | 96.46 |