| SMVA TrustEIN 23-2785411 | International | TX | $1,015,991Small | 92.22 |
| Snow Leopard TrustEIN 91-1144119 | Animals | WA | $2,389,563Small | 93.73 |
| Social Venture PartnersEIN 91-1894424 | Research and Public Policy | WA | $2,722,955Small | 83.35 |
| Sociedad LatinaEIN 04-2678255 | Human Services | MA | $1,814,005Small | 93.02 |
| Society for Classical StudiesEIN 13-6018127 | Education | NY | $1,277,954Small | 93.82 |
| Society for the Improvement of Conditions for Stray AnimalsEIN 23-7367199 | Animals | OH | $1,504,640Small | 95.60 |
| Society for Women's Health ResearchEIN 52-1694732 | Human and Civil Rights | DC | $1,749,602Small | 81.80 |
| Soil Born Farms Urban Agriculture & Education ProjectEIN 20-0774693 | Education | CA | $1,888,739Small | 79.87 |
| Solar Cookers InternationalEIN 68-0153141 | Environment | CA | $773,030Small | 91.37 |
| Solid GroundEIN 36-3578158 | Human Services | MN | $1,371,215Small | 97.58 |
| Solid Rock InternationalEIN 34-1719319 | Religion | IN | $1,389,061Small | 96.88 |
| SoliyaEIN 32-0060209 | International | NY | $1,365,656Small | 72.22 |
| Solutions for ChangeEIN 33-0902617 | Human Services | CA | $3,329,200Small | 79.52 |
| SOLVEEIN 93-0579286 | Environment | OR | $1,209,987Small | 78.43 |
| Solve ME/CFS InitiativeEIN 56-1683450 | Health | CA | $1,925,767Small | 88.69 |
| Sonoma Valley Education FoundationEIN 68-0279152 | Education | CA | $1,722,094Small | 81.79 |
| Sonoran InstituteEIN 86-0684610 | Environment | AZ | $2,969,310Small | 82.94 |
| Sons of Italy FoundationEIN 23-6276526 | Community Development | DC | $991,230Small | 77.48 |
| SonScape RetreatsEIN 74-2372030 | Religion | CO | $1,005,888Small | 73.32 |
| SoundWatersEIN 06-1263947 | Environment | CT | $2,007,465Small | 94.48 |
| South Africa Development FundEIN 22-2674813 | International | MA | $904,837Small | 78.60 |
| South Asian Youth ActionEIN 13-3943630 | Human Services | NY | $3,370,395Small | 95.04 |
| South Boston Neighborhood HouseEIN 04-2104807 | Human Services | MA | $1,756,067Small | 84.90 |
| South Carolina Governor's School for Science and Math FoundationEIN 57-0881347 | Education | SC | $2,340,649Small | 86.43 |
| South Carolina Woman's Missionary UnionEIN 57-0362065 | Religion | SC | $2,531,177Small | 79.42 |
| South Dakota Symphony OrchestraEIN 46-6017026 | Arts, Culture, Humanities | SD | $1,927,737Small | 83.34 |
| South Florida MuseumEIN 59-0598726 | Arts, Culture, Humanities | FL | $3,401,335Small | 87.76 |
| South Hills Interfaith MovementEIN 25-1213332 | Human Services | PA | $2,330,337Small | 88.07 |
| South Shore Habitat for HumanityEIN 22-2701789 | Community Development | MA | $2,438,899Small | 94.69 |
| South Street Seaport MuseumEIN 13-2596500 | Arts, Culture, Humanities | NY | $3,179,707Small | 82.13 |
| Southeast Alaska Conservation CouncilEIN 92-0062992 | Environment | AK | $589,607Small | 82.59 |
| Southeastern Children's HomeEIN 23-7061916 | Human Services | SC | $1,045,679Small | 89.15 |
| Southeastern Legal FoundationEIN 58-1247027 | Human and Civil Rights | GA | $3,057,517Small | 88.92 |
| Southern Center for Human RightsEIN 62-1025326 | Human and Civil Rights | GA | $2,747,262Small | 99.34 |
| Southern Center for International StudiesEIN 58-1285654 | International | GA | $978,904Small | 81.80 |
| Southern Oregon Humane SocietyEIN 93-0391640 | Animals | OR | $893,883Small | 95.57 |
| Southern Partners FundEIN 58-2409301 | Human Services | GA | $1,225,922Small | 77.64 |
| Southern Scholarship FoundationEIN 59-0939481 | Education | FL | $1,950,039Small | 94.17 |
| Southern Utah Wilderness AllianceEIN 94-2936961 | Environment | UT | $2,658,079Small | 93.68 |
| Southside Early Childhood CenterEIN 43-0685348 | Human Services | MO | $2,611,208Small | 89.14 |
| Southwest Center for HIV/AIDSEIN 86-0695862 | Health | AZ | $3,377,818Small | 86.42 |
| Southwest Christian CareEIN 58-1849504 | Human Services | GA | $2,109,260Small | 73.34 |
| SOZO InternationalEIN 20-0166014 | International | CO | $1,452,252Small | 86.00 |
| Spartanburg Humane SocietyEIN 57-0481019 | Animals | SC | $1,598,762Small | 81.52 |
| SPCA of Anne Arundel CountyEIN 52-0609154 | Animals | MD | $1,645,867Small | 95.00 |
| SPCA of Luzerne CountyEIN 24-0855811 | Animals | PA | $1,218,527Small | 80.67 |
| SPCA of Wake CountyEIN 56-0891732 | Animals | NC | $2,819,747Small | 86.57 |
| SPCA of WestchesterEIN 13-1740069 | Animals | NY | $2,832,609Small | 100.00 |
| Special K RanchEIN 36-3378581 | Human Services | MT | $1,872,180Small | 90.04 |
| Special Olympics ChicagoEIN 23-7026774 | Human Services | IL | $1,938,952Small | 69.94 |
| Special Olympics DelawareEIN 23-7162877 | Human Services | DE | $1,795,879Small | 88.10 |
| Special Olympics HawaiiEIN 23-7173957 | Human Services | HI | $2,490,312Small | 92.65 |
| Special Olympics IdahoEIN 23-7185185 | Human Services | ID | $789,375Small | 78.93 |
| Special Olympics IowaEIN 51-0176029 | Human Services | IA | $2,539,940Small | 83.25 |
| Special Olympics LouisianaEIN 72-0706608 | Human Services | LA | $1,807,182Small | 76.42 |
| Special Olympics MaineEIN 01-0355822 | Human Services | ME | $1,238,463Small | 83.42 |
| Special Olympics MontanaEIN 81-0367064 | Human Services | MT | $2,626,115Small | 96.16 |
| Special Olympics NebraskaEIN 47-0546346 | Human Services | NE | $2,069,635Small | 84.88 |
| Special Olympics New HampshireEIN 23-7207522 | Human Services | NH | $1,437,290Small | 80.17 |
| Special Olympics New MexicoEIN 85-0268084 | Human Services | NM | $1,782,183Small | 78.45 |