| Special Olympics of Rhode IslandEIN 05-0377867 | Human Services | RI | $1,725,626Small | 80.02 |
| Special Olympics OklahomaEIN 23-7174120 | Human Services | OK | $1,669,667Small | 90.94 |
| Special Olympics South CarolinaEIN 57-0680248 | Human Services | SC | $2,816,864Small | 91.89 |
| Special Olympics South DakotaEIN 46-0359776 | Human Services | SD | $1,508,882Small | 92.62 |
| Special Olympics TennesseeEIN 23-7348136 | Human Services | TN | $1,738,490Small | 85.72 |
| Spina Bifida AssociationEIN 58-1342181 | Health | VA | $1,821,008Small | 82.11 |
| Splash InternationalEIN 56-2600599 | International | WA | $3,266,231Small | 94.18 |
| Spokane Valley PartnersEIN 91-1478830 | Human Services | WA | $3,099,717Small | 82.63 |
| Spondylitis Association of AmericaEIN 95-3890767 | Health | CA | $1,301,054Small | 91.90 |
| Sports Outreach InstituteEIN 54-1479310 | Religion | VA | $1,923,423Small | 85.93 |
| Sports World, Inc.EIN 23-7073822 | Religion | IN | $1,106,989Small | 75.82 |
| Sportsmen's Alliance FoundationEIN 31-0941103 | Animals | OH | $1,443,394Small | 89.30 |
| Sportsmen's Tennis & Enrichment CenterEIN 23-7037183 | Human Services | MA | $1,815,033Small | 83.64 |
| Springfield Victory MissionEIN 43-1345089 | Human Services | MO | $2,352,783Small | 79.57 |
| SquashBustersEIN 04-3330698 | Education | MA | $2,154,696Small | 91.21 |
| St. Francis CenterEIN 95-4479271 | Human Services | CA | $3,444,965Small | 87.34 |
| St. Gerard CampusEIN 59-2483955 | Human Services | FL | $756,996Small | 74.01 |
| St. John CenterEIN 61-1135907 | Human Services | KY | $1,261,698Small | 88.93 |
| St. Louis Public Library FoundationEIN 43-1541947 | Arts, Culture, Humanities | MO | $744,456Small | 79.60 |
| St. Mary's CenterEIN 68-0172229 | Human Services | CA | $3,039,558Small | 96.66 |
| St. Mary's Dining RoomEIN 94-2687280 | Human Services | CA | $2,522,317Small | 87.86 |
| St. Mary's SewaneeEIN 62-1359755 | Religion | TN | $915,612Small | 74.38 |
| Stamford Symphony OrchestraEIN 06-6100039 | Arts, Culture, Humanities | CT | $1,439,725Small | 80.32 |
| Stand.earthEIN 94-3331587 | Environment | CA | $3,081,289Small | 88.89 |
| StandUp for KidsEIN 33-0414855 | Human Services | GA | $1,220,228Small | 92.02 |
| State Street BalletEIN 86-0717486 | Arts, Culture, Humanities | CA | $1,295,799Small | 80.63 |
| Staten Island Economic Development Corporation (SIEDC)EIN 13-3706442 | Community Development | NY | $1,787,552Small | 86.03 |
| STEPEIN 51-0188692 | Human Services | MN | $2,169,879Small | 93.36 |
| Stephen's Children FoundationEIN 58-2219199 | International | MI | $1,332,560Small | 71.83 |
| SteppingStone TheatreEIN 36-3557115 | Education | MN | $871,063Small | 79.18 |
| Stern Grove Festival AssociationEIN 94-6064356 | Arts, Culture, Humanities | CA | $2,645,452Small | 80.95 |
| Stevens-Swan Humane Society of Oneida CountyEIN 15-0551485 | Animals | NY | $1,087,872Small | 77.21 |
| Stewpot Community ServicesEIN 64-0655566 | Human Services | MS | $2,160,764Small | 91.15 |
| Still Creek RanchEIN 74-2614076 | Human Services | TX | $2,387,828Small | 67.40 |
| Stony Brook Millstone Watershed Association EIN 21-0649717 | Environment | NJ | $2,183,497Small | 91.01 |
| Storyteller Children's CenterEIN 77-0283072 | Human Services | CA | $1,611,343Small | 91.38 |
| Straight Ahead MinistriesEIN 04-3103694 | Human Services | MA | $2,008,144Small | 85.29 |
| Strawbery Banke MuseumEIN 02-0260158 | Arts, Culture, Humanities | NH | $3,204,942Small | 93.92 |
| Streams MinistriesEIN 74-2703460 | Religion | TX | $1,018,510Small | 60.02 |
| Street Law, Inc.EIN 52-2015256 | Education | MD | $1,726,408Small | 85.34 |
| Street SchoolEIN 73-0942963 | Education | OK | $2,022,478Small | 97.66 |
| Streets MinistriesEIN 62-1763815 | Human Services | TN | $2,137,688Small | 92.33 |
| Strings Music FestivalEIN 84-1101995 | Arts, Culture, Humanities | CO | $2,051,356Small | 89.13 |
| Students Run LAEIN 95-4430502 | Human Services | CA | $2,637,828Small | 97.10 |
| Suffolk County Police Athletic LeagueEIN 23-7356002 | Human Services | NY | $1,095,091Small | 76.76 |
| Summer Camp Opportunities Promote Education (SCOPE)EIN 20-2772242 | Education | NY | $713,151Small | 72.80 |
| Suncoast Humane SocietyEIN 23-7174193 | Animals | FL | $2,251,735Small | 83.19 |
| Sunday Breakfast Rescue MissionEIN 23-1352558 | Human Services | PA | $3,017,157Small | 79.81 |
| Sunflower HouseEIN 48-0918698 | Human Services | KS | $1,483,883Small | 93.82 |
| Sunny Glen Children's HomeEIN 74-1260706 | Human Services | TX | $2,484,409Small | 88.16 |
| Sunshine FoundationEIN 23-2044056 | Health | PA | $1,149,331Small | 84.68 |
| Sunshine MinistriesEIN 43-0896665 | Human Services | MO | $1,553,900Small | 79.61 |
| Sunvalley Summer SymphonyEIN 82-0397940 | Arts, Culture, Humanities | ID | $3,471,245Small | 83.13 |
| SuperChannel WACX-TVEIN 59-1798262 | Religion | FL | $2,508,450Small | 56.43 |
| Support Circle Pregnancy ClinicsEIN 94-2937281 | Health | CA | $1,470,007Small | 76.06 |
| Support Our Aging ReligiousEIN 52-1485481 | Religion | DC | $2,598,741Small | 87.13 |
| Support The Enlisted Project (STEP)EIN 20-3051279 | Human Services | CA | $1,681,670Small | 94.41 |
| Supportive Housing Network of New YorkEIN 13-3755149 | Research and Public Policy | NY | $1,876,483Small | 87.00 |
| Susquehanna Council Boy Scouts of AmericaEIN 24-0795397 | Human Services | PA | $924,817Small | 86.77 |
| Sustainable Food CenterEIN 74-2441468 | Human Services | TX | $2,309,673Small | 91.45 |