| Rehabilitation Center for Children and AdultsEIN 59-0791037 | Health | FL | $2,835,023Small | 88.29 |
| Religious Community ServicesEIN 59-1309186 | Human Services | FL | $9,886,130Mid-sized | 91.45 |
| Rodeheaver Boys RanchEIN 59-0830750 | Human Services | FL | $1,967,247Small | 94.56 |
| Ronald McDonald House Charities of Central FloridaEIN 59-3211250 | Health | FL | $3,418,782Small | 91.33 |
| Ronald McDonald House Charities of JacksonvilleEIN 59-2625008 | Health | FL | $3,069,398Small | 90.58 |
| Ronald McDonald House Charities of Northwest FloridaEIN 59-2172279 | Health | FL | $1,578,712Small | 88.73 |
| Ronald McDonald House Charities of South FloridaEIN 59-1899866 | Health | FL | $2,137,980Small | 84.91 |
| Ronald McDonald House Charities of Southwest FloridaEIN 11-3704163 | Health | FL | $1,109,274Small | 80.59 |
| Ronald McDonald House Charities of Tampa BayEIN 59-1835985 | Health | FL | $3,252,462Small | 93.36 |
| Ruth & Norman Rales Jewish Family ServiceEIN 65-1115689 | Human Services | FL | $11,478,842Mid-sized | 95.05 |
| Salvador Dalí MuseumEIN 59-2015192 | Arts, Culture, Humanities | FL | $10,091,648Mid-sized | 86.60 |
| Salvadoran American Humanitarian FoundationEIN 59-2339140 | International | FL | $25,123,269Large | 94.69 |
| Samaritan Center for Young Boys & FamiliesEIN 59-1373247 | Human Services | FL | $503,874Small | 73.91 |
| Sanibel-Captiva Conservation FoundationEIN 59-1205087 | Environment | FL | $3,095,476Small | 90.45 |
| Sarasota OperaEIN 23-7089047 | Arts, Culture, Humanities | FL | $8,600,781Mid-sized | 86.80 |
| Sarasota OrchestraEIN 59-2603081 | Arts, Culture, Humanities | FL | $9,770,009Mid-sized | 90.31 |
| Save the Manatee ClubEIN 59-3131709 | Animals | FL | $1,168,356Small | 90.23 |
| Sea Turtle ConservancyEIN 59-6151069 | Animals | FL | $3,339,353Small | 96.46 |
| Second Harvest Food Bank of Central FloridaEIN 59-2142315 | Human Services | FL | $122,484,539Large | 92.92 |
| Shake-A-Leg MiamiEIN 65-0611917 | Education | FL | $2,152,655Small | 83.20 |
| ShelterBox USAEIN 20-0471604 | International | FL | $5,478,172Mid-sized | 94.42 |
| Sheridan House Family MinistriesEIN 59-1258384 | Human Services | FL | $4,200,026Mid-sized | 90.19 |
| Shriners Hospitals for ChildrenEIN 36-2193608 | Health | FL | $856,243,943Large | 95.61 |
| SKY Family YMCAEIN 59-1629660 | Human Services | FL | $14,895,916Large | 91.77 |
| Society of the Four ArtsEIN 59-0454318 | Arts, Culture, Humanities | FL | $8,133,941Mid-sized | 86.63 |
| South Florida MuseumEIN 59-0598726 | Arts, Culture, Humanities | FL | $3,401,335Small | 87.76 |
| South Florida PBSEIN 59-0737868 | Arts, Culture, Humanities | FL | $18,553,742Large | 78.65 |
| South Florida Science Center and AquariumEIN 59-0915177 | Arts, Culture, Humanities | FL | $3,583,072Mid-sized | 90.59 |
| South Florida Wildlife CenterEIN 23-7086391 | Animals | FL | $3,713,493Mid-sized | 78.77 |
| Southeastern Guide DogsEIN 59-2252352 | Animals | FL | $9,239,038Mid-sized | 95.32 |
| Southern Scholarship FoundationEIN 59-0939481 | Education | FL | $1,950,039Small | 94.17 |
| SPCA Tampa BayEIN 59-0715928 | Animals | FL | $5,909,487Mid-sized | 82.57 |
| Special Olympics FloridaEIN 23-7181560 | Human Services | FL | $13,729,105Large | 92.61 |
| Special Operations Warrior FoundationEIN 52-1183585 | Education | FL | $11,730,490Mid-sized | 94.47 |
| St. Gerard CampusEIN 59-2483955 | Human Services | FL | $756,996Small | 74.01 |
| St. Matthew's HouseEIN 65-1110501 | Human Services | FL | $7,624,221Mid-sized | 92.14 |
| St. Petersburg Free ClinicEIN 23-7208280 | Health | FL | $12,323,655Mid-sized | 97.17 |
| Step Up For StudentsEIN 59-3649371 | Education | FL | $674,603,917Large | 96.66 |
| Sulzbacher CenterEIN 59-3229898 | Human Services | FL | $14,566,080Large | 92.02 |
| Suncoast Humane SocietyEIN 23-7174193 | Animals | FL | $2,251,735Small | 83.19 |
| SuperChannel WACX-TVEIN 59-1798262 | Religion | FL | $2,508,450Small | 56.43 |
| Susan B. Anthony Recovery CenterEIN 65-0583089 | Human Services | FL | $3,840,666Mid-sized | 79.43 |
| Take Stock in ChildrenEIN 59-3331584 | Education | FL | $8,938,574Mid-sized | 87.88 |
| Take Stock in Children Palm Beach CountyEIN 20-8077416 | Education | FL | $1,371,374Small | 91.59 |
| Tampa Metropolitan Area YMCAEIN 59-1742909 | Human Services | FL | $33,632,520Large | 92.49 |
| Teen Missions InternationalEIN 23-7125177 | Religion | FL | $3,049,497Small | 72.21 |
| The Aleph InstituteEIN 59-2291627 | Human Services | FL | $3,717,868Mid-sized | 80.10 |
| The Billfish FoundationEIN 59-2694327 | Animals | FL | $1,217,072Small | 79.61 |
| The Buoniconti Fund to Cure ParalysisEIN 65-0244316 | Health | FL | $7,655,599Mid-sized | 90.51 |
| The Center of Anna Maria IslandEIN 59-6166231 | Human Services | FL | $1,497,901Small | 76.58 |
| The Chi Chi Rodriguez Youth FoundationEIN 59-2017124 | Education | FL | $2,156,579Small | 89.51 |
| The Community Foundation for Northeast FloridaEIN 59-6150746 | Community Development | FL | $41,921,959Large | 93.74 |
| The Community Foundation of Sarasota CountyEIN 59-1956886 | Community Development | FL | $38,090,969Large | 91.34 |
| The Cummer Museum of Art & GardensEIN 59-2191587 | Arts, Culture, Humanities | FL | $4,800,748Mid-sized | 86.34 |
| The Education Foundation of Collier CountyEIN 65-0230582 | Education | FL | $2,224,265Small | 97.14 |
| The Education FundEIN 59-2468114 | Education | FL | $2,612,408Small | 86.44 |
| The Florida AquariumEIN 59-2807815 | Animals | FL | $18,265,885Large | 90.00 |
| The Florida Bar FoundationEIN 59-1004604 | Human and Civil Rights | FL | $13,470,190Mid-sized | 79.94 |
| The Florida OrchestraEIN 59-1223691 | Arts, Culture, Humanities | FL | $10,882,617Mid-sized | 89.92 |
| The GatheringEIN 59-2810392 | Religion | FL | $1,469,520Small | 73.72 |