| Chapman School of SeamanshipEIN 59-1416396 | Education | FL | $1,966,950Small | 76.20 |
| Charcot-Marie-Tooth AssociationEIN 22-2480896 | Health | PA | $2,539,687Small | 87.39 |
| Charity CarsEIN 59-3362703 | Human Services | FL | $7,458,283Mid-sized | 94.74 |
| Charity MotorsEIN 38-3251827 | Human Services | MI | $6,804,600Mid-sized | 54.61 |
| Charity NewsiesEIN 31-6401150 | Human Services | OH | $1,919,088Small | 94.28 |
| Charity VisionEIN 77-0222786 | International | UT | $11,957,329Mid-sized | 96.66 |
| charity: waterEIN 22-3936753 | International | NY | $35,902,241Large | 91.16 |
| Charles H. Wright Museum of African American HistoryEIN 38-1882096 | Arts, Culture, Humanities | MI | $6,275,367Mid-sized | 82.26 |
| Charles River Watershed AssociationEIN 04-6136989 | Environment | MA | $1,159,643Small | 76.43 |
| Charleston Animal SocietyEIN 57-6021863 | Animals | SC | $7,048,049Mid-sized | 94.16 |
| Charleston Symphony OrchestraEIN 57-6000192 | Arts, Culture, Humanities | SC | $3,490,071Small | 89.02 |
| Charleston Wine + Food FestivalEIN 20-2671674 | Arts, Culture, Humanities | SC | $3,135,643Small | 85.49 |
| Charlotte BalletEIN 58-1314711 | Arts, Culture, Humanities | NC | $7,537,739Mid-sized | 93.80 |
| Charlotte Family HousingEIN 58-1599120 | Human Services | NC | $3,197,515Small | 93.41 |
| Charlotte Rescue MissionEIN 56-0571223 | Human Services | NC | $6,345,655Mid-sized | 87.26 |
| Charlotte Symphony OrchestraEIN 56-6011568 | Arts, Culture, Humanities | NC | $9,930,801Mid-sized | 76.92 |
| Charlottesville Free ClinicEIN 54-1610405 | Health | VA | $4,215,026Mid-sized | 89.71 |
| Charlottesville-Albemarle SPCAEIN 54-0595009 | Animals | VA | $3,518,707Mid-sized | 86.45 |
| Chattahoochee RiverkeeperEIN 58-2095413 | Environment | GA | $2,483,987Small | 95.05 |
| Chattanooga Area Food BankEIN 62-0867645 | Human Services | TN | $28,411,914Large | 93.49 |
| Chattanooga Symphony & OperaEIN 62-6002098 | Arts, Culture, Humanities | TN | $2,521,056Small | 87.15 |
| Cheekwood Botanical Garden & Museum of ArtEIN 62-0627921 | Arts, Culture, Humanities | TN | $10,709,480Mid-sized | 96.66 |
| Cheetah Conservation FundEIN 31-1726923 | Animals | VA | $2,458,012Small | 91.55 |
| Cherokee National Historical SocietyEIN 73-6103406 | Arts, Culture, Humanities | OK | $1,360,287Small | 58.58 |
| Cherry Creek Arts FestivalEIN 74-2546811 | Arts, Culture, Humanities | CO | $2,530,675Small | 84.55 |
| Cherry Street Mission MinistriesEIN 34-1133369 | Human Services | OH | $6,252,648Mid-sized | 83.69 |
| Chesapeake Bay Maritime MuseumEIN 23-7051889 | Arts, Culture, Humanities | MD | $4,451,861Mid-sized | 94.91 |
| Chesapeake Bay TrustEIN 52-1454182 | Environment | MD | $12,114,935Mid-sized | 97.23 |
| Chesapeake Climate Action NetworkEIN 11-3644283 | Environment | MD | $1,350,959Small | 91.29 |
| Chesapeake ConservancyEIN 26-2271377 | Environment | MD | $4,045,632Mid-sized | 97.13 |
| Chess in the SchoolsEIN 13-6119036 | Education | NY | $2,849,813Small | 84.95 |
| CHEST FoundationEIN 36-3286520 | Health | IL | $1,575,560Small | 89.58 |
| Cheyenne Mountain ZooEIN 84-0407039 | Animals | CO | $13,534,283Large | 92.94 |
| Chicago Academy of Sciences / Peggy Notebaert Nature MuseumEIN 36-0895575 | Arts, Culture, Humanities | IL | $6,434,381Mid-sized | 87.59 |
| Chicago Arts Partnerships in EducationEIN 36-3969334 | Education | IL | $1,393,218Small | 81.00 |
| Chicago Bar FoundationEIN 36-6109584 | Human and Civil Rights | IL | $4,461,315Mid-sized | 88.90 |
| Chicago Botanic GardenEIN 36-2225482 | Environment | IL | $48,755,048Large | 88.85 |
| Chicago CaresEIN 36-3777709 | Community Development | IL | $3,287,575Small | 90.59 |
| Chicago Children's ChoirEIN 51-0140419 | Education | IL | $4,025,337Mid-sized | 82.63 |
| Chicago Children's MuseumEIN 36-3162484 | Arts, Culture, Humanities | IL | $7,043,221Mid-sized | 81.00 |
| Chicago Coalition for the HomelessEIN 36-3292607 | Human Services | IL | $2,898,914Small | 100.00 |
| Chicago Gateway GreenEIN 36-3764084 | Environment | IL | $618,570Small | 82.05 |
| Chicago History MuseumEIN 36-2167004 | Arts, Culture, Humanities | IL | $16,954,477Large | 77.98 |
| Chicago Hope AcademyEIN 36-4244054 | Education | IL | $4,257,955Mid-sized | 84.66 |
| Chicago Humanities FestivalEIN 36-7148236 | Arts, Culture, Humanities | IL | $3,736,155Mid-sized | 83.39 |
| Chicago Lawyers' Committee for Civil Rights Under LawEIN 51-0189264 | Human and Civil Rights | IL | $2,101,380Small | 86.04 |
| Chicago Legal ClinicEIN 36-3200465 | Human and Civil Rights | IL | $2,536,631Small | 88.29 |
| Chicago LightsEIN 36-3786331 | Human Services | IL | $2,284,416Small | 90.66 |
| Chicago Police Memorial FoundationEIN 56-2450501 | Human Services | IL | $1,841,097Small | 76.44 |
| Chicago Public Library FoundationEIN 36-3480353 | Arts, Culture, Humanities | IL | $7,357,415Mid-sized | 92.92 |
| Chicago Public MediaEIN 36-3687394 | Arts, Culture, Humanities | IL | $24,050,416Large | 83.37 |
| Chicago Scholars FoundationEIN 36-4117530 | Education | IL | $4,037,945Mid-sized | 90.73 |
| Chicago Shakespeare TheaterEIN 36-3467607 | Arts, Culture, Humanities | IL | $16,536,820Large | 90.52 |
| Chicago Symphony OrchestraEIN 36-2167823 | Arts, Culture, Humanities | IL | $79,669,618Large | 83.61 |
| Chicago Volunteer Legal ServicesEIN 23-7164989 | Human and Civil Rights | IL | $2,503,172Small | 82.20 |
| Chicago Youth CentersEIN 36-2344429 | Human Services | IL | $8,586,171Mid-sized | 87.30 |
| Chicago Youth ProgramsEIN 36-3635676 | Human Services | IL | $1,256,471Small | 95.05 |
| Chicago Zoological SocietyEIN 36-2167016 | Animals | IL | $73,409,870Large | 86.85 |
| Child Abuse NetworkEIN 73-1325326 | Human Services | OK | $1,356,882Small | 88.33 |
| Child AdvocatesEIN 76-0111345 | Human Services | TX | $5,333,168Mid-sized | 91.93 |