| Center for Teaching QualityEIN 04-3606319 | Education | NC | $2,140,229Small | 84.11 |
| Center for the HomelessEIN 35-1768544 | Human Services | IN | $3,240,450Small | 85.36 |
| Center for the National InterestEIN 26-2117013 | Research and Public Policy | DC | $4,008,865Mid-sized | 89.04 |
| Center for the New EconomyEIN 66-0566096 | Research and Public Policy | PR | $2,308,832Small | 87.15 |
| Center for the Study of Social PolicyEIN 52-1254948 | Human Services | DC | $13,048,910Mid-sized | 89.42 |
| Center for Third World OrganizingEIN 52-1211059 | Human and Civil Rights | CA | $679,062Small | 59.78 |
| Center for Urban Renewal and EducationEIN 31-1467594 | Research and Public Policy | DC | $1,671,710Small | 78.59 |
| Center for Women & EnterpriseEIN 04-3256236 | Community Development | MA | $2,797,407Small | 84.58 |
| Center for Women in TransitionEIN 38-2181204 | Human Services | MI | $2,733,719Small | 90.72 |
| Center for Wooden BoatsEIN 91-1061721 | Education | WA | $1,600,728Small | 73.42 |
| Center of ConcernEIN 52-0941367 | Human and Civil Rights | DC | $931,090Small | 61.71 |
| Center of the American ExperimentEIN 36-3611426 | Research and Public Policy | MN | $2,247,617Small | 77.54 |
| Center on Budget and Policy PrioritiesEIN 52-1234565 | Research and Public Policy | DC | $28,721,352Large | 90.53 |
| Center on HalstedEIN 51-0178807 | Human and Civil Rights | IL | $6,293,773Mid-sized | 97.46 |
| Center on Policy InitiativesEIN 33-0824881 | Research and Public Policy | CA | $2,041,680Small | 91.84 |
| Center StageEIN 52-0780194 | Arts, Culture, Humanities | MD | $9,050,818Mid-sized | 86.65 |
| Centers for the Arts of Bonita SpringsEIN 65-0295085 | Arts, Culture, Humanities | FL | $2,634,919Small | 85.14 |
| Central American Medical OutreachEIN 34-1740695 | International | OH | $2,489,025Small | 86.05 |
| Central Asia InstituteEIN 51-0376237 | International | MT | $5,291,098Mid-sized | 84.66 |
| Central California Food BankEIN 77-0320851 | Human Services | CA | $65,008,490Large | 94.67 |
| Central Coast Alliance United for A Sustainable EconomyEIN 77-0578864 | Human and Civil Rights | CA | $1,051,634Small | 88.85 |
| Central Florida YMCAEIN 59-0624430 | Human Services | FL | $59,588,094Large | 85.96 |
| Central Florida Zoo & Botanical GardensEIN 59-1357197 | Animals | FL | $5,702,682Mid-sized | 92.50 |
| Central Illinois FoodbankEIN 37-1106465 | Human Services | IL | $18,256,991Large | 92.92 |
| Central Indiana Community FoundationEIN 35-1793680 | Community Development | IN | $27,466,633Large | 91.42 |
| Central Institute for the DeafEIN 43-0662456 | Education | MO | $7,510,069Mid-sized | 93.44 |
| Central Iowa Shelter & ServicesEIN 42-1394212 | Human Services | IA | $2,529,003Small | 90.09 |
| Central New York Community FoundationEIN 15-0626910 | Community Development | NY | $22,768,461Large | 97.89 |
| Central Ohio Diabetes AssociationEIN 31-6054100 | Health | OH | $1,223,080Small | 73.68 |
| Central Oklahoma Habitat for HumanityEIN 73-1305668 | Community Development | OK | $10,160,701Mid-sized | 91.18 |
| Central Park ConservancyEIN 13-3022855 | Environment | NY | $72,425,618Large | 94.20 |
| Central Pennsylvania Food BankEIN 23-2202250 | Human Services | PA | $83,599,202Large | 98.23 |
| Central ScholarshipEIN 52-6012589 | Education | MD | $1,899,217Small | 96.74 |
| Central Texas Food BankEIN 74-2217350 | Human Services | TX | $88,983,352Large | 96.46 |
| Central Union MissionEIN 53-0218650 | Human Services | DC | $16,421,755Large | 89.86 |
| Centre County United WayEIN 25-1215290 | Community Development | PA | $1,792,114Small | 91.96 |
| Centre Pompidou FoundationEIN 13-2941675 | Arts, Culture, Humanities | CA | $7,552,193Mid-sized | 92.22 |
| CentroEIN 41-1290349 | Human Services | MN | $1,493,898Small | 90.38 |
| Centro Legal De La RazaEIN 23-7181456 | Human and Civil Rights | CA | $5,659,231Mid-sized | 92.22 |
| Centurion MinistriesEIN 22-2563979 | Human and Civil Rights | NJ | $1,587,880Small | 92.25 |
| Cerebral PalsyEIN 39-0901265 | Health | WI | $6,080,335Mid-sized | 88.99 |
| Cerebral Palsy FoundationEIN 13-6093337 | Health | NY | $1,808,965Small | 82.51 |
| CeresEIN 22-3053747 | Environment | MA | $14,937,631Large | 96.52 |
| CERGE-EI FoundationEIN 25-1725738 | International | NJ | $3,260,105Small | 92.14 |
| CETEIN 31-0560051 | Arts, Culture, Humanities | OH | $5,016,398Mid-sized | 84.20 |
| CFES Brilliant PathwaysEIN 22-3159630 | Education | NY | $3,564,584Mid-sized | 84.83 |
| Chabad's Children of ChernobylEIN 13-3722594 | International | NY | $172,434Small | 58.25 |
| Chai LifelineEIN 11-2940331 | Human Services | NY | $19,233,028Large | 86.18 |
| Challenge AspenEIN 84-1315910 | Human Services | CO | $3,320,748Small | 100.00 |
| Challenged Athletes FoundationEIN 33-0739596 | Human Services | CA | $8,869,120Mid-sized | 84.16 |
| Challenged Child & FriendsEIN 58-1622732 | Education | GA | $2,311,777Small | 80.16 |
| Chamber Music AmericaEIN 13-2934575 | Arts, Culture, Humanities | NY | $2,826,648Small | 91.12 |
| Chamber Music NorthwestEIN 23-7355562 | Arts, Culture, Humanities | OR | $1,637,657Small | 95.38 |
| Chamber Music Society of Lincoln CenterEIN 13-2628036 | Arts, Culture, Humanities | NY | $8,916,142Mid-sized | 91.66 |
| Champaign County Humane SocietyEIN 37-0714217 | Animals | IL | $1,058,761Small | 85.28 |
| Changed LivesEIN 62-6081698 | Religion | TN | $1,145,541Small | 94.37 |
| Channel 3 Kids CampEIN 06-0660003 | Education | CT | $2,401,293Small | 70.71 |
| Channel Islands YMCAEIN 95-1643379 | Human Services | CA | $18,458,636Large | 90.64 |
| Channel One Regional Food BankEIN 41-1379713 | Human Services | MN | $15,937,633Large | 92.05 |
| Chapman PartnershipEIN 65-0425069 | Human Services | FL | $16,277,068Large | 95.11 |