| American Friends of the Hebrew UniversityEIN 13-1568923 | Education | NY | $60,923,877Large | 87.98 |
| American Friends of the Israel Democracy InstituteEIN 13-3348313 | International | GA | $8,396,726Mid-sized | 73.82 |
| American Friends of the Israel MuseumEIN 23-7182582 | Arts, Culture, Humanities | NY | $17,264,366Large | 85.11 |
| American Friends of the Israel National Museum of ScienceEIN 13-3329462 | Arts, Culture, Humanities | NY | $1,274,004Small | 84.82 |
| American Friends of the Israel Philharmonic OrchestraEIN 23-7183563 | Arts, Culture, Humanities | NY | $6,296,009Mid-sized | 86.19 |
| American Friends of the LouvreEIN 52-2376786 | Arts, Culture, Humanities | NY | $4,755,697Mid-sized | 92.02 |
| American Friends of the Open University of IsraelEIN 13-3091674 | Education | NY | $1,111,082Small | 84.69 |
| American Friends of The Tel Aviv UniversityEIN 13-1996126 | Education | NY | $36,078,234Large | 93.25 |
| American Friends of Yad EliezerEIN 11-3459952 | Human Services | NJ | $41,944,264Large | 94.69 |
| American Friends of Yeshivot Bnei AkivaEIN 52-6080692 | Education | NY | $688,740Small | 69.87 |
| American Heart AssociationEIN 13-5613797 | Health | TX | $827,059,831Large | 88.07 |
| American Hiking SocietyEIN 51-0211993 | Environment | MD | $1,010,896Small | 77.15 |
| American Himalayan FoundationEIN 94-2951480 | International | CA | $5,218,592Mid-sized | 95.06 |
| American Horticultural SocietyEIN 53-0226408 | Environment | VA | $2,954,031Small | 87.74 |
| American HumaneEIN 84-0432950 | Animals | DC | $15,536,919Large | 90.25 |
| American Humanist AssociationEIN 94-6168317 | Human and Civil Rights | DC | $2,295,879Small | 93.41 |
| American Immigration CouncilEIN 52-1549711 | Human and Civil Rights | DC | $5,483,109Mid-sized | 94.52 |
| American India FoundationEIN 13-4159765 | International | NY | $7,577,120Mid-sized | 91.04 |
| American Indian College FundEIN 52-1573446 | Education | CO | $24,590,104Large | 83.67 |
| American Indian Science and Engineering SocietyEIN 73-1023474 | Human Services | NM | $4,132,365Mid-sized | 86.99 |
| American Indian ServicesEIN 87-0477049 | Education | UT | $2,559,455Small | 90.91 |
| American Institute for Contemporary German StudiesEIN 52-1309525 | International | DC | $1,959,488Small | 86.76 |
| American Institute for Economic ResearchEIN 04-2121305 | Research and Public Policy | MA | $4,008,116Mid-sized | 78.56 |
| American Israel Education FoundationEIN 52-1623781 | Education | DC | $56,112,739Large | 81.71 |
| American Italian Cancer FoundationEIN 13-3035711 | Health | NY | $1,688,237Small | 91.63 |
| American Jewish CongressEIN 13-1679610 | International | NY | $544,808Small | 53.76 |
| American Jewish Historical SocietyEIN 13-1764804 | Arts, Culture, Humanities | NY | $2,541,630Small | 71.93 |
| American Jewish Joint Distribution CommitteeEIN 13-1656634 | International | NY | $317,102,196Large | 96.37 |
| American Kennel Club Canine Health FoundationEIN 13-3813813 | Animals | NC | $3,097,717Small | 92.32 |
| American Legislative Exchange CouncilEIN 52-0140979 | Research and Public Policy | VA | $9,056,582Mid-sized | 80.87 |
| American Leprosy MissionsEIN 13-5562163 | International | SC | $14,437,414Large | 87.06 |
| American Life LeagueEIN 52-1238301 | Human and Civil Rights | VA | $3,632,951Mid-sized | 70.76 |
| American Liver FoundationEIN 36-2883000 | Health | NY | $8,921,259Mid-sized | 87.43 |
| American Lung Association of the Midland StatesEIN 31-4379531 | Health | OH | $7,270,087Mid-sized | 87.46 |
| American Lung Association, National HeadquartersEIN 13-1632524 | Health | IL | $39,339,462Large | 83.94 |
| American Medical Association FoundationEIN 36-6080517 | Health | IL | $2,759,140Small | 68.05 |
| American Museum of Natural HistoryEIN 13-6162659 | Arts, Culture, Humanities | NY | $214,025,292Large | 90.52 |
| American Nicaraguan FoundationEIN 65-0326517 | International | FL | $107,910,005Large | 97.44 |
| American Nonsmokers' Rights FoundationEIN 94-2922136 | Human and Civil Rights | CA | $2,848,886Small | 92.13 |
| American Printing House For The BlindEIN 61-0444640 | Human Services | KY | $18,252,464Large | 84.71 |
| American Psychiatric Association FoundationEIN 13-0433740 | Health | DC | $5,462,166Mid-sized | 86.81 |
| American Public Gardens AssociationEIN 23-7110058 | Environment | PA | $2,276,779Small | 84.24 |
| American Quarter Horse FoundationEIN 51-0187823 | Education | TX | $3,881,056Mid-sized | 84.61 |
| American Red CrossEIN 53-0196605 | Human Services | DC | $3,142,984,060Large | 88.71 |
| American Refugee CommitteeEIN 36-3241033 | International | MN | $45,843,947Large | 96.46 |
| American Relief Agency for the Horn of Africa (ARAHA)EIN 41-1989714 | International | MN | $6,168,900Mid-sized | 92.74 |
| American Repertory BalletEIN 21-0732575 | Arts, Culture, Humanities | NJ | $4,032,932Mid-sized | 80.78 |
| American RiversEIN 23-7305963 | Environment | DC | $14,465,768Large | 86.37 |
| American Sexual Health AssociationEIN 94-2494435 | Human and Civil Rights | NC | $2,166,882Small | 91.93 |
| American Skin AssociationEIN 13-3401320 | Health | NY | $1,405,914Small | 92.92 |
| American Society for the Defense of Tradition, Family and PropertyEIN 23-7325778 | Religion | PA | $14,478,944Large | 78.93 |
| American Society for the Prevention of Cruelty to AnimalsEIN 13-1623829 | Animals | NY | $208,434,628Large | 83.75 |
| American Society for the Protection of Nature in IsraelEIN 52-1467954 | Animals | NY | $1,822,784Small | 91.16 |
| American Society for Yad VashemEIN 13-3106768 | Arts, Culture, Humanities | NY | $16,168,788Large | 92.22 |
| American Society of Transplant SurgeonsEIN 13-3048373 | Health | VA | $5,646,358Mid-sized | 83.97 |
| American Society of TransplantationEIN 42-1182936 | Health | NJ | $4,846,825Mid-sized | 90.68 |
| American Studies CenterEIN 51-0232804 | Research and Public Policy | VA | $7,739,721Mid-sized | 78.15 |
| American Swedish InstituteEIN 41-0711603 | Arts, Culture, Humanities | MN | $4,258,783Mid-sized | 88.46 |
| American Symphony OrchestraEIN 13-1969375 | Arts, Culture, Humanities | NY | $3,301,829Small | 76.28 |
| American Technion SocietyEIN 13-0434195 | Education | NY | $102,913,014Large | 93.52 |