| Louisiana Children's MuseumEIN 72-0929068 | Arts, Culture, Humanities | LA | $2,248,572Small | 85.55 |
| Louisiana Philharmonic OrchestraEIN 72-1189023 | Arts, Culture, Humanities | LA | $5,568,310Mid-sized | 86.72 |
| Louisiana Resource Center for EducatorsEIN 58-1704372 | Education | LA | $1,493,374Small | 71.54 |
| Louisiana SPCAEIN 72-0471368 | Animals | LA | $8,212,256Mid-sized | 96.30 |
| Louisiana Symphony AssociationEIN 72-6001959 | Arts, Culture, Humanities | LA | $2,049,050Small | 72.62 |
| Louisville BalletEIN 61-6033779 | Arts, Culture, Humanities | KY | $4,486,519Mid-sized | 88.95 |
| Louisville Central Community CenterEIN 61-0590743 | Human Services | KY | $1,575,467Small | 80.89 |
| Louisville Free Public Library FoundationEIN 61-0969361 | Arts, Culture, Humanities | KY | $3,582,104Mid-sized | 93.15 |
| Louisville OrchestraEIN 61-6000384 | Arts, Culture, Humanities | KY | $6,751,076Mid-sized | 88.89 |
| Louisville Public MediaEIN 61-1259787 | Arts, Culture, Humanities | KY | $6,051,773Mid-sized | 93.37 |
| Louisville Urban LeagueEIN 61-0444771 | Human and Civil Rights | KY | $3,979,281Mid-sized | 93.11 |
| Love A Child, Inc.EIN 59-2672303 | International | FL | $64,009,080Large | 94.28 |
| Love in the Name of ChristEIN 38-2578829 | Human Services | MI | $1,967,779Small | 81.60 |
| Love Without Boundaries FoundationEIN 06-1710161 | International | OK | $2,095,217Small | 90.71 |
| Love Worth FindingEIN 58-1730035 | Religion | TN | $5,564,717Mid-sized | 79.58 |
| Love146EIN 20-1168284 | Human Services | CT | $3,770,196Mid-sized | 86.96 |
| Lovelane Special Needs Horseback Riding ProgramEIN 04-3139666 | Health | MA | $1,169,575Small | 78.97 |
| Loving Grace MinistriesEIN 52-1160024 | Religion | NJ | $1,080,302Small | 69.01 |
| Lowcountry Food BankEIN 57-0751835 | Human Services | SC | $51,794,129Large | 90.42 |
| Lowell ObservatoryEIN 86-0098918 | Research and Public Policy | AZ | $12,648,803Mid-sized | 88.56 |
| Lower Cape Outreach CouncilEIN 04-2864255 | Human Services | MA | $1,191,323Small | 81.54 |
| Lower Manhattan Cultural CouncilEIN 23-7348782 | Arts, Culture, Humanities | NY | $3,660,793Mid-sized | 87.43 |
| Loyalhanna Watershed AssociationEIN 23-7135993 | Environment | PA | $681,889Small | 84.54 |
| Lubbock Area United WayEIN 75-0961812 | Community Development | TX | $5,582,174Mid-sized | 98.93 |
| Lubbock Meals on WheelsEIN 75-1333736 | Human Services | TX | $1,332,605Small | 85.04 |
| Luis Palau AssociationEIN 93-0713827 | Religion | OR | $9,118,819Mid-sized | 83.26 |
| LumberyardEIN 52-2158599 | Arts, Culture, Humanities | NY | $5,356,697Mid-sized | 84.71 |
| LuMind Research Down Syndrome FoundationEIN 37-1483975 | Health | MA | $2,821,799Small | 85.38 |
| Lung Cancer AllianceEIN 91-1821040 | Health | DC | $3,992,235Mid-sized | 82.85 |
| Lung Cancer Research FoundationEIN 14-1935776 | Health | NY | $4,554,246Mid-sized | 92.20 |
| LUNGevity FoundationEIN 36-4433410 | Health | IL | $7,605,367Mid-sized | 90.96 |
| Lupus Foundation of AmericaEIN 43-1131436 | Health | DC | $13,256,140Mid-sized | 72.88 |
| Lupus Research AllianceEIN 58-2492929 | Health | NY | $28,260,250Large | 91.47 |
| Lutheran Bible TranslatorsEIN 95-2630437 | Religion | MO | $3,933,406Mid-sized | 93.26 |
| Lutheran Heritage FoundationEIN 38-3106702 | Religion | MI | $2,309,004Small | 88.72 |
| Lutheran Homes of South Carolina FoundationEIN 57-0342978 | Human Services | SC | $2,029,254Small | 91.16 |
| Lutheran Indian MinistriesEIN 39-1509253 | Religion | WI | $2,151,386Small | 83.27 |
| Lutheran Music ProgramEIN 47-0638445 | Arts, Culture, Humanities | MN | $1,097,899Small | 79.63 |
| Lydia's HouseEIN 43-1699278 | Human Services | MO | $1,356,848Small | 94.18 |
| Lymphoma Research FoundationEIN 95-4335088 | Health | NY | $8,784,268Mid-sized | 79.06 |
| Lynn Sage Cancer Research FoundationEIN 36-3727715 | Health | IL | $245,075Small | 92.92 |
| Lyric Opera of ChicagoEIN 36-6008929 | Arts, Culture, Humanities | IL | $86,475,933Large | 89.58 |
| Lyric Opera of Kansas CityEIN 44-0626124 | Arts, Culture, Humanities | MO | $6,714,592Mid-sized | 89.96 |
| Lyric TheatreEIN 73-1001687 | Arts, Culture, Humanities | OK | $4,634,911Mid-sized | 90.34 |
| Maccabi USA/Sports for IsraelEIN 13-1810938 | Human Services | PA | $1,938,346Small | 75.73 |
| Mackinac CenterEIN 38-2701547 | Research and Public Policy | MI | $6,608,146Mid-sized | 92.92 |
| Macomb County Humane SocietyEIN 38-6120195 | Animals | MI | $828,307Small | 90.32 |
| MacPhail Center for MusicEIN 41-1729340 | Education | MN | $12,206,724Mid-sized | 88.48 |
| Macula Vision Research FoundationEIN 23-2876473 | Health | PA | $823,042Small | 86.25 |
| Macular Degeneration AssociationEIN 27-3025707 | Health | FL | $1,288,362Small | 73.72 |
| Madison Children's MuseumEIN 39-1383497 | Arts, Culture, Humanities | WI | $3,527,783Mid-sized | 75.57 |
| Madison Public Library FoundationEIN 39-1777242 | Arts, Culture, Humanities | WI | $1,412,832Small | 82.71 |
| Madison Square Boys & Girls ClubEIN 13-5596792 | Human Services | NY | $10,016,984Mid-sized | 92.12 |
| Madison Square Park ConservancyEIN 14-1859935 | Environment | NY | $4,811,212Mid-sized | 85.67 |
| MADREEIN 13-3280194 | International | NY | $4,284,836Mid-sized | 95.83 |
| Magic Johnson FoundationEIN 95-4349860 | Health | CA | $1,043,609Small | 79.21 |
| Mahaiwe Performing Arts CenterEIN 57-1140453 | Arts, Culture, Humanities | MA | $2,292,098Small | 84.68 |
| Mahoning Valley Historical SocietyEIN 34-0872868 | Arts, Culture, Humanities | OH | $1,151,615Small | 80.94 |
| Main Line Animal RescueEIN 23-3017210 | Animals | PA | $2,690,621Small | 86.15 |
| Main Stay Therapeutic FarmEIN 36-3565747 | Health | IL | $924,836Small | 95.05 |