| American Composers ForumEIN 23-7452688 | Arts, Culture, Humanities | MN | $1,550,517Small | 85.47 |
| American Composers OrchestraEIN 13-2838450 | Arts, Culture, Humanities | NY | $1,629,135Small | 88.39 |
| American Conservatory TheaterEIN 94-6135772 | Arts, Culture, Humanities | CA | $23,341,174Large | 89.42 |
| American Constitution Society for Law and PolicyEIN 52-2313694 | Research and Public Policy | DC | $5,891,120Mid-sized | 88.13 |
| American Council on Science and HealthEIN 13-2911127 | Research and Public Policy | NY | $1,729,003Small | 86.87 |
| American Dance FestivalEIN 06-0932294 | Arts, Culture, Humanities | NC | $3,568,666Mid-sized | 87.64 |
| American DocumentaryEIN 13-3447752 | Arts, Culture, Humanities | NY | $4,013,582Mid-sized | 89.53 |
| American Enterprise Institute for Public Policy ResearchEIN 53-0218495 | Research and Public Policy | DC | $55,822,303Large | 87.22 |
| American Federation for Children Growth FundEIN 52-2111508 | Education | DC | $7,828,481Mid-sized | 83.70 |
| American Film InstituteEIN 52-6072925 | Arts, Culture, Humanities | CA | $30,818,470Large | 80.43 |
| American Folk Art MuseumEIN 13-1985627 | Arts, Culture, Humanities | NY | $4,220,031Mid-sized | 85.39 |
| American ForestsEIN 53-0196544 | Environment | DC | $5,495,270Mid-sized | 86.81 |
| American Foundation For Children With AIDSEIN 30-0247823 | International | PA | $1,841,016Small | 87.96 |
| American Foundation for Suicide PreventionEIN 13-3393329 | Health | NY | $23,219,954Large | 89.12 |
| American Foundation for the BlindEIN 13-5562161 | Human Services | VA | $12,764,530Mid-sized | 84.99 |
| American Friends of ALYN HospitalEIN 13-6100833 | Health | NY | $3,113,775Small | 86.75 |
| American Friends of Beit Issie ShapiroEIN 13-3434781 | Human Services | NY | $2,203,983Small | 84.82 |
| American Friends of IDCEIN 31-1577589 | Education | NY | $19,778,201Large | 86.56 |
| American Friends of Leket IsraelEIN 20-8202424 | International | NJ | $5,856,154Mid-sized | 88.19 |
| American Friends of Magen David AdomEIN 13-1790719 | Health | NY | $34,622,656Large | 85.50 |
| American Friends of Neve Shalom/Wahat al-SalamEIN 13-3441742 | International | CA | $492,665Small | 83.89 |
| American Friends of Shalva IsraelEIN 56-2676533 | Human Services | NY | $4,298,752Mid-sized | 87.30 |
| American Friends of the Hebrew UniversityEIN 13-1568923 | Education | NY | $60,923,877Large | 87.98 |
| American Friends of the Israel MuseumEIN 23-7182582 | Arts, Culture, Humanities | NY | $17,264,366Large | 85.11 |
| American Friends of the Israel National Museum of ScienceEIN 13-3329462 | Arts, Culture, Humanities | NY | $1,274,004Small | 84.82 |
| American Friends of the Israel Philharmonic OrchestraEIN 23-7183563 | Arts, Culture, Humanities | NY | $6,296,009Mid-sized | 86.19 |
| American Friends of the Open University of IsraelEIN 13-3091674 | Education | NY | $1,111,082Small | 84.69 |
| American Heart AssociationEIN 13-5613797 | Health | TX | $827,059,831Large | 88.07 |
| American Horticultural SocietyEIN 53-0226408 | Environment | VA | $2,954,031Small | 87.74 |
| American Indian College FundEIN 52-1573446 | Education | CO | $24,590,104Large | 83.67 |
| American Indian Science and Engineering SocietyEIN 73-1023474 | Human Services | NM | $4,132,365Mid-sized | 86.99 |
| American Institute for Contemporary German StudiesEIN 52-1309525 | International | DC | $1,959,488Small | 86.76 |
| American Israel Education FoundationEIN 52-1623781 | Education | DC | $56,112,739Large | 81.71 |
| American Legislative Exchange CouncilEIN 52-0140979 | Research and Public Policy | VA | $9,056,582Mid-sized | 80.87 |
| American Leprosy MissionsEIN 13-5562163 | International | SC | $14,437,414Large | 87.06 |
| American Liver FoundationEIN 36-2883000 | Health | NY | $8,921,259Mid-sized | 87.43 |
| American Lung Association of the Midland StatesEIN 31-4379531 | Health | OH | $7,270,087Mid-sized | 87.46 |
| American Lung Association, National HeadquartersEIN 13-1632524 | Health | IL | $39,339,462Large | 83.94 |
| American Printing House For The BlindEIN 61-0444640 | Human Services | KY | $18,252,464Large | 84.71 |
| American Psychiatric Association FoundationEIN 13-0433740 | Health | DC | $5,462,166Mid-sized | 86.81 |
| American Public Gardens AssociationEIN 23-7110058 | Environment | PA | $2,276,779Small | 84.24 |
| American Quarter Horse FoundationEIN 51-0187823 | Education | TX | $3,881,056Mid-sized | 84.61 |
| American Red CrossEIN 53-0196605 | Human Services | DC | $3,142,984,060Large | 88.71 |
| American Repertory BalletEIN 21-0732575 | Arts, Culture, Humanities | NJ | $4,032,932Mid-sized | 80.78 |
| American RiversEIN 23-7305963 | Environment | DC | $14,465,768Large | 86.37 |
| American Society for the Prevention of Cruelty to AnimalsEIN 13-1623829 | Animals | NY | $208,434,628Large | 83.75 |
| American Society of Transplant SurgeonsEIN 13-3048373 | Health | VA | $5,646,358Mid-sized | 83.97 |
| American Swedish InstituteEIN 41-0711603 | Arts, Culture, Humanities | MN | $4,258,783Mid-sized | 88.46 |
| American Theatre WingEIN 13-1893906 | Arts, Culture, Humanities | NY | $2,895,023Small | 89.28 |
| American Tinnitus AssociationEIN 93-0749558 | Health | VA | $918,238Small | 81.62 |
| Americans for Peace NowEIN 13-3509867 | International | DC | $1,602,208Small | 82.25 |
| Americans For Prosperity FoundationEIN 52-1527294 | Human and Civil Rights | VA | $23,028,942Large | 81.16 |
| Americans United for Separation of Church and StateEIN 53-0184647 | Human and Civil Rights | DC | $7,210,878Mid-sized | 81.63 |
| Americas SocietyEIN 13-2569185 | International | NY | $6,259,184Mid-sized | 87.88 |
| AMG InternationalEIN 13-1766596 | Religion | TN | $6,760,457Mid-sized | 89.17 |
| Amherst H. Wilder FoundationEIN 41-0693889 | Human Services | MN | $45,788,233Large | 86.30 |
| Amigos de JesusEIN 23-3027589 | Human Services | PA | $1,391,900Small | 83.73 |
| Amigos de las AméricasEIN 74-1547146 | International | TX | $4,223,247Mid-sized | 86.98 |
| Amnesty International USAEIN 52-0851555 | International | NY | $39,020,245Large | 89.40 |
| Amoud FoundationEIN 75-2882187 | International | TX | $4,108,828Mid-sized | 86.79 |