| MERS Missouri Goodwill IndustriesEIN 43-0652657 | Human Services | MO | $161,570,313Large | 88.08 |
| Mesorah Heritage FoundationEIN 11-2981112 | Religion | NY | $8,542,211Mid-sized | 84.50 |
| Mesothelioma Applied Research FoundationEIN 75-2816066 | Health | DC | $2,190,623Small | 89.12 |
| Messianic Jewish Bible InstituteEIN 75-2812348 | Religion | TX | $1,757,135Small | 89.80 |
| Metro United WayEIN 61-0444680 | Community Development | KY | $25,634,353Large | 88.69 |
| Metropolitan Family ServicesEIN 36-2167940 | Human Services | IL | $40,309,248Large | 89.20 |
| MetroSquashEIN 20-2614486 | Human Services | IL | $2,204,245Small | 82.89 |
| Mexican American Legal Defense and Educational FundEIN 74-1563270 | Human and Civil Rights | CA | $6,747,829Mid-sized | 87.37 |
| Miami City BalletEIN 59-2578534 | Arts, Culture, Humanities | FL | $16,618,823Large | 84.95 |
| Michigan 4-H FoundationEIN 38-1539997 | Human Services | MI | $2,237,051Small | 80.60 |
| Michigan Community ResourcesEIN 20-5764501 | Community Development | MI | $1,072,508Small | 82.06 |
| Michigan Opera TheatreEIN 38-2052726 | Arts, Culture, Humanities | MI | $15,538,195Large | 85.35 |
| Mid America Assistance CoalitionEIN 43-1186173 | Human Services | MO | $1,257,864Small | 82.29 |
| Mid-Atlantic Foundation for Safety and EducationEIN 23-3100128 | Research and Public Policy | DE | $1,089,582Small | 82.32 |
| Mid-Iowa Council, Boy Scouts of AmericaEIN 42-0981715 | Human Services | IA | $3,162,411Small | 80.64 |
| Mid-Willamette Family YMCAEIN 93-0479079 | Human Services | OR | $3,059,581Small | 83.43 |
| Middle East ForumEIN 23-7749796 | Research and Public Policy | PA | $3,682,718Mid-sized | 88.61 |
| Middle Georgia Community Food BankEIN 58-2484086 | Human Services | GA | $10,581,893Mid-sized | 89.45 |
| Middle Tyger Community CenterEIN 57-1077940 | Human Services | SC | $1,068,622Small | 85.81 |
| Middle Way HouseEIN 23-7300355 | Human Services | IN | $2,098,358Small | 85.73 |
| Middlesex United WayEIN 06-0665170 | Community Development | CT | $1,706,457Small | 87.05 |
| Midland Community TheatreEIN 75-6003774 | Arts, Culture, Humanities | TX | $1,940,871Small | 85.18 |
| Midland-Odessa Symphony & ChoraleEIN 75-1301544 | Arts, Culture, Humanities | TX | $1,183,096Small | 89.29 |
| Midnight Golf ProgramEIN 38-3580432 | Human Services | MI | $1,521,282Small | 85.54 |
| Midtown Educational FoundationEIN 36-3417278 | Education | IL | $3,162,988Small | 81.33 |
| Midwest Organic & Sustainable Education ServicesEIN 39-1824623 | Education | WI | $1,371,688Small | 82.93 |
| Midwest Shelter for Homeless VeteransEIN 36-4337985 | Human Services | IL | $1,379,606Small | 86.11 |
| MIFA (Metropolitan Inter-Faith Association)EIN 62-0803601 | Human Services | TN | $9,032,602Mid-sized | 86.92 |
| Mike Silva InternationalEIN 37-3963621 | Religion | OR | $1,558,668Small | 88.55 |
| Mile High MinistriesEIN 84-0782214 | Religion | CO | $3,366,410Small | 80.83 |
| Mile High United WayEIN 84-0404235 | Community Development | CO | $27,515,091Large | 89.00 |
| Military Community Youth MinistriesEIN 74-2238462 | Religion | CO | $1,630,660Small | 84.91 |
| Milwaukee BalletEIN 39-1134735 | Arts, Culture, Humanities | WI | $6,450,332Mid-sized | 89.90 |
| Milwaukee Symphony OrchestraEIN 39-6023436 | Arts, Culture, Humanities | WI | $18,202,182Large | 84.79 |
| Mind & Life InstituteEIN 77-0284767 | Research and Public Policy | VA | $3,552,029Mid-sized | 89.22 |
| Minneapolis Jewish FederationEIN 41-0693866 | Community Development | MN | $15,487,288Large | 86.47 |
| Minnesota Children's MuseumEIN 41-1354181 | Arts, Culture, Humanities | MN | $9,321,847Mid-sized | 88.69 |
| Minnesota Environmental FundEIN 41-1693030 | Environment | MN | $964,468Small | 86.29 |
| Minnesota Historical SocietyEIN 41-0713907 | Arts, Culture, Humanities | MN | $60,451,270Large | 89.84 |
| Minnesota Museum of American ArtEIN 41-0726138 | Arts, Culture, Humanities | MN | $1,469,148Small | 89.23 |
| Minnesota OperaEIN 41-0946789 | Arts, Culture, Humanities | MN | $11,190,288Mid-sized | 85.27 |
| Minnesota State Fair FoundationEIN 41-2013696 | Arts, Culture, Humanities | MN | $1,855,342Small | 83.39 |
| Minnesota Zoo FoundationEIN 51-0147653 | Animals | MN | $3,820,920Mid-sized | 85.60 |
| Minnetrista Gathering PlaceEIN 35-1628916 | Arts, Culture, Humanities | IN | $4,487,847Mid-sized | 80.09 |
| Miracle Hill MinistriesEIN 57-0425826 | Human Services | SC | $17,579,619Large | 89.75 |
| Mission BlueEIN 26-1892969 | Environment | CA | $1,261,676Small | 80.39 |
| Mission EurasiaEIN 35-1835273 | Religion | IL | $4,262,417Mid-sized | 86.84 |
| Mission GranburyEIN 75-2766222 | Human Services | TX | $1,304,142Small | 85.84 |
| Mission of HopeEIN 62-1794508 | Human Services | TN | $2,958,234Small | 85.07 |
| Mission PossibleEIN 34-1290940 | Religion | OH | $1,114,129Small | 84.18 |
| Mission to HaitiEIN 59-2173214 | International | FL | $667,035Small | 83.54 |
| Mission Without BordersEIN 77-0292572 | International | CA | $1,198,470Small | 81.84 |
| Missionary Athletes InternationalEIN 33-0017152 | Religion | NC | $3,442,558Small | 83.18 |
| Missionary Maintenance Service AviationEIN 31-0919027 | Religion | OH | $1,854,255Small | 81.53 |
| Mississippi Center for JusticeEIN 13-4203234 | Human and Civil Rights | MS | $3,606,434Mid-sized | 86.39 |
| Missouri Botanical GardenEIN 43-0666759 | Environment | MO | $45,210,838Large | 87.76 |
| MN Community MeasurementEIN 35-2246162 | Research and Public Policy | MN | $3,570,442Mid-sized | 83.18 |
| Modest NeedsEIN 47-0863430 | Human Services | NY | $1,226,134Small | 83.84 |
| Modesto Gospel MissionEIN 94-6102833 | Human Services | CA | $6,196,894Mid-sized | 81.69 |
| Moffitt Cancer Center FoundationEIN 59-3238636 | Health | FL | $26,895,692Large | 82.04 |