| South Street Seaport MuseumEIN 13-2596500 | Arts, Culture, Humanities | NY | $3,179,707Small | 82.13 |
| Southeast Alaska Conservation CouncilEIN 92-0062992 | Environment | AK | $589,607Small | 82.59 |
| Southeastern Children's HomeEIN 23-7061916 | Human Services | SC | $1,045,679Small | 89.15 |
| Southeastern Legal FoundationEIN 58-1247027 | Human and Civil Rights | GA | $3,057,517Small | 88.92 |
| Southern California Public RadioEIN 95-4765734 | Arts, Culture, Humanities | CA | $27,593,781Large | 85.94 |
| Southern Center for International StudiesEIN 58-1285654 | International | GA | $978,904Small | 81.80 |
| Southern Poverty Law CenterEIN 63-0598743 | Human and Civil Rights | AL | $59,784,321Large | 88.78 |
| Southside Early Childhood CenterEIN 43-0685348 | Human Services | MO | $2,611,208Small | 89.14 |
| Southwest Center for HIV/AIDSEIN 86-0695862 | Health | AZ | $3,377,818Small | 86.42 |
| Southwest School of ArtEIN 74-6068932 | Education | TX | $5,289,868Mid-sized | 84.25 |
| SOZO InternationalEIN 20-0166014 | International | CO | $1,452,252Small | 86.00 |
| Spartanburg Humane SocietyEIN 57-0481019 | Animals | SC | $1,598,762Small | 81.52 |
| SPCA of Luzerne CountyEIN 24-0855811 | Animals | PA | $1,218,527Small | 80.67 |
| SPCA of Wake CountyEIN 56-0891732 | Animals | NC | $2,819,747Small | 86.57 |
| SPCA Serving Erie CountyEIN 16-0425315 | Animals | NY | $6,268,446Mid-sized | 86.67 |
| SPCA Tampa BayEIN 59-0715928 | Animals | FL | $5,909,487Mid-sized | 82.57 |
| spcaLAEIN 95-1738153 | Animals | CA | $7,647,760Mid-sized | 85.75 |
| Special Olympics ConnecticutEIN 23-7099756 | Human Services | CT | $5,001,707Mid-sized | 87.93 |
| Special Olympics DelawareEIN 23-7162877 | Human Services | DE | $1,795,879Small | 88.10 |
| Special Olympics GeorgiaEIN 23-7201676 | Human Services | GA | $3,924,681Mid-sized | 87.01 |
| Special Olympics IowaEIN 51-0176029 | Human Services | IA | $2,539,940Small | 83.25 |
| Special Olympics MaineEIN 01-0355822 | Human Services | ME | $1,238,463Small | 83.42 |
| Special Olympics MarylandEIN 23-7089144 | Human Services | MD | $4,631,154Mid-sized | 89.88 |
| Special Olympics MassachusettsEIN 23-7242294 | Human Services | MA | $4,403,489Mid-sized | 82.89 |
| Special Olympics MinnesotaEIN 41-1228157 | Human Services | MN | $6,699,150Mid-sized | 87.44 |
| Special Olympics MissouriEIN 23-7328374 | Human Services | MO | $4,342,896Mid-sized | 88.50 |
| Special Olympics NebraskaEIN 47-0546346 | Human Services | NE | $2,069,635Small | 84.88 |
| Special Olympics New HampshireEIN 23-7207522 | Human Services | NH | $1,437,290Small | 80.17 |
| Special Olympics of Rhode IslandEIN 05-0377867 | Human Services | RI | $1,725,626Small | 80.02 |
| Special Olympics TennesseeEIN 23-7348136 | Human Services | TN | $1,738,490Small | 85.72 |
| Special Olympics TexasEIN 74-1998367 | Human Services | TX | $9,080,131Mid-sized | 86.84 |
| Special Olympics VirginiaEIN 54-1013637 | Human Services | VA | $4,833,080Mid-sized | 89.91 |
| Special Olympics WashingtonEIN 91-0962383 | Human Services | WA | $4,115,372Mid-sized | 85.40 |
| Special Olympics WisconsinEIN 39-1176591 | Human Services | WI | $4,554,211Mid-sized | 82.06 |
| Speedway Children's CharitiesEIN 56-1331429 | Education | NC | $3,925,136Mid-sized | 86.80 |
| Spence-Chapin Services to Families and ChildrenEIN 13-1834590 | Human Services | NY | $7,266,046Mid-sized | 81.35 |
| Spina Bifida AssociationEIN 58-1342181 | Health | VA | $1,821,008Small | 82.11 |
| Spokane County United WayEIN 91-0606058 | Community Development | WA | $4,118,437Mid-sized | 86.72 |
| Spokane Valley PartnersEIN 91-1478830 | Human Services | WA | $3,099,717Small | 82.63 |
| Spoleto Festival USAEIN 57-0660848 | Arts, Culture, Humanities | SC | $8,737,036Mid-sized | 82.85 |
| Sports Outreach InstituteEIN 54-1479310 | Religion | VA | $1,923,423Small | 85.93 |
| Sportsmen's Alliance FoundationEIN 31-0941103 | Animals | OH | $1,443,394Small | 89.30 |
| Sportsmen's Tennis & Enrichment CenterEIN 23-7037183 | Human Services | MA | $1,815,033Small | 83.64 |
| Springfield Library and Museums AssociationEIN 04-6002239 | Arts, Culture, Humanities | MA | $7,616,989Mid-sized | 87.57 |
| Springfield Rescue MissionEIN 52-1047790 | Human Services | MA | $5,894,186Mid-sized | 80.93 |
| Springs Rescue MissionEIN 84-1340824 | Human Services | CO | $11,053,485Mid-sized | 87.91 |
| SPUREIN 94-1498232 | Research and Public Policy | CA | $6,462,777Mid-sized | 88.07 |
| St. Francis CenterEIN 95-4479271 | Human Services | CA | $3,444,965Small | 87.34 |
| St. Francis HouseEIN 22-2519129 | Human Services | MA | $8,991,131Mid-sized | 83.47 |
| St. John CenterEIN 61-1135907 | Human Services | KY | $1,261,698Small | 88.93 |
| St. John's Bread & LifeEIN 11-3174514 | Human Services | NY | $4,064,642Mid-sized | 89.71 |
| St. Mary's Dining RoomEIN 94-2687280 | Human Services | CA | $2,522,317Small | 87.86 |
| St. Patrick CenterEIN 43-1263499 | Human Services | MO | $16,391,436Large | 85.08 |
| St. Rita School for the DeafEIN 31-0537509 | Education | OH | $6,147,225Mid-sized | 87.66 |
| St. Vincent de Paul DetroitEIN 38-1359592 | Human Services | MI | $15,821,834Large | 89.01 |
| St. Vincent de Paul of Seattle|King CountyEIN 91-0583891 | Human Services | WA | $10,749,665Mid-sized | 85.01 |
| St. Vincent de Paul VillageEIN 33-0492302 | Human Services | CA | $31,913,973Large | 81.26 |
| St. Vincent Meals on WheelsEIN 95-3696693 | Human Services | CA | $8,085,613Mid-sized | 86.11 |
| Stamford Center for the ArtsEIN 06-1048684 | Arts, Culture, Humanities | CT | $3,601,344Mid-sized | 86.08 |
| Stamford Symphony OrchestraEIN 06-6100039 | Arts, Culture, Humanities | CT | $1,439,725Small | 80.32 |