| The Second StepEIN 22-2868513 | Human Services | MA | $1,830,231Small | 81.36 |
| The SEED FoundationEIN 54-1850819 | Education | DC | $5,472,657Mid-sized | 89.48 |
| The Seeing EyeEIN 22-1539721 | Animals | NJ | $27,150,791Large | 85.82 |
| The SentryEIN 20-8827879 | International | DC | $2,861,789Small | 89.39 |
| The Shade TreeEIN 88-0253276 | Human Services | NV | $3,411,140Small | 89.89 |
| The Shakespeare Theatre of New JerseyEIN 22-1962163 | Arts, Culture, Humanities | NJ | $4,083,714Mid-sized | 87.14 |
| The Sharing CenterEIN 59-2744535 | Human Services | FL | $3,997,342Mid-sized | 88.85 |
| The Shea Center for Therapeutic RidingEIN 95-3351363 | Health | CA | $3,757,858Mid-sized | 89.18 |
| The SheepfoldEIN 95-3426900 | Human Services | CA | $2,577,494Small | 87.25 |
| The Sheldon Arts FoundationEIN 43-1489756 | Arts, Culture, Humanities | MO | $3,282,775Small | 89.73 |
| The Sikh CoalitionEIN 22-3834037 | Human and Civil Rights | NY | $1,580,818Small | 89.79 |
| The Society of St. AndrewEIN 54-1285793 | Human Services | VA | $15,925,960Large | 87.66 |
| The Society of St. Vincent de Paul GeorgiaEIN 58-0967972 | Human Services | GA | $15,390,829Large | 89.52 |
| The Source for WomenEIN 76-0025661 | Health | TX | $1,488,827Small | 86.75 |
| The South Carolina Historical SocietyEIN 57-0323800 | Arts, Culture, Humanities | SC | $950,748Small | 84.84 |
| The Sphinx OrganizationEIN 38-3283759 | Arts, Culture, Humanities | MI | $5,008,617Mid-sized | 85.61 |
| The Spring of Tampa BayEIN 59-1777135 | Human Services | FL | $4,256,840Mid-sized | 89.55 |
| The Steppingstone FoundationEIN 04-3086666 | Education | MA | $4,848,517Mid-sized | 81.68 |
| The Sun Valley Center for the ArtsEIN 23-7113276 | Arts, Culture, Humanities | ID | $3,229,667Small | 87.30 |
| The Sunlight FoundationEIN 20-3903427 | Human and Civil Rights | DC | $1,451,359Small | 81.08 |
| The Supreme Court Historical SocietyEIN 23-7420574 | Arts, Culture, Humanities | DC | $2,694,765Small | 82.95 |
| The THANC FoundationEIN 80-0062118 | Health | NY | $1,981,338Small | 87.04 |
| The Tribe ClubEIN 54-6056480 | Education | VA | $6,675,496Mid-sized | 80.90 |
| The Trinity ForumEIN 54-1612640 | Education | DC | $1,119,991Small | 86.40 |
| The Tulsa Symphony OrchestraEIN 20-3798077 | Arts, Culture, Humanities | OK | $2,164,852Small | 86.90 |
| The Ulman Cancer Fund for Young AdultsEIN 52-2057636 | Health | MD | $2,454,766Small | 86.10 |
| The United Way of Amarillo & CanyonEIN 75-0800600 | Community Development | TX | $4,858,845Mid-sized | 85.52 |
| The United Way of Clark, Champaign and Madison Counties OhioEIN 31-0549095 | Community Development | OH | $1,439,544Small | 89.33 |
| The Urban AlternativeEIN 75-1835253 | Religion | TX | $11,099,552Mid-sized | 86.59 |
| The Valentine Richmond History CenterEIN 54-0505967 | Arts, Culture, Humanities | VA | $2,787,806Small | 88.94 |
| The Valentine TheatreEIN 34-1385037 | Arts, Culture, Humanities | OH | $1,642,428Small | 80.66 |
| The W. Haywood Burns InstituteEIN 81-0594086 | Human and Civil Rights | CA | $3,972,480Mid-sized | 87.78 |
| The Wild CenterEIN 14-1811534 | Environment | NY | $5,741,631Mid-sized | 86.69 |
| The Wilderness SocietyEIN 53-0167933 | Environment | DC | $31,030,390Large | 89.71 |
| The Wing Luke Museum of the Asian Pacific American ExperienceEIN 91-6067431 | Arts, Culture, Humanities | WA | $2,713,683Small | 82.92 |
| The Women's Center, VirginiaEIN 23-7423496 | Human Services | VA | $2,865,951Small | 83.90 |
| The Women's Center, WisconsinEIN 39-1269698 | Human Services | WI | $2,192,093Small | 86.46 |
| The Women's Foundation of ColoradoEIN 84-1039305 | Human and Civil Rights | CO | $3,377,212Small | 85.58 |
| The Women's Fund Miami-DadeEIN 65-0436923 | Human and Civil Rights | FL | $793,154Small | 82.19 |
| The Women's Fund of Central OhioEIN 31-1784310 | Human and Civil Rights | OH | $1,517,707Small | 86.18 |
| The Women's HomeEIN 74-1467811 | Human Services | TX | $4,186,752Mid-sized | 89.15 |
| The Wooden FloorEIN 33-0299356 | Education | CA | $2,732,524Small | 85.41 |
| The Woodruff Arts CenterEIN 58-0633971 | Arts, Culture, Humanities | GA | $96,220,136Large | 87.65 |
| The Woodson CenterEIN 52-1217891 | Community Development | DC | $5,621,177Mid-sized | 84.04 |
| The Zoo SocietyEIN 91-6066667 | Animals | WA | $2,428,208Small | 89.19 |
| Theatre Bay AreaEIN 94-2476071 | Arts, Culture, Humanities | CA | $1,042,524Small | 81.82 |
| Theatre Under The StarsEIN 74-1621647 | Arts, Culture, Humanities | TX | $17,408,127Large | 87.85 |
| Thelonious Monk Institute of JazzEIN 52-1544030 | Arts, Culture, Humanities | DC | $4,330,076Mid-sized | 88.81 |
| Theological Book NetworkEIN 35-2166244 | Religion | MI | $2,758,802Small | 84.99 |
| There With CareEIN 68-0606330 | Health | CO | $2,086,139Small | 80.80 |
| Thermal Belt Outreach MinistryEIN 56-1793796 | Human Services | NC | $1,217,403Small | 87.09 |
| Think SmallEIN 41-1260581 | Human Services | MN | $34,542,069Large | 88.29 |
| This Is The Place FoundationEIN 84-1426573 | Environment | UT | $6,104,884Mid-sized | 88.14 |
| Thistle FarmsEIN 58-2050089 | Human Services | TN | $3,578,410Mid-sized | 88.43 |
| Thomas Irvine Dodge Nature CenterEIN 41-6081794 | Environment | MN | $2,497,503Small | 89.57 |
| Thomas More Law CenterEIN 38-3448297 | Human and Civil Rights | MI | $1,799,459Small | 81.10 |
| Thompson Child & Family FocusEIN 56-0547460 | Human Services | NC | $15,157,223Large | 81.11 |
| Thrive Counseling CenterEIN 36-2179793 | Health | IL | $2,143,605Small | 88.22 |
| Thrive NetworksEIN 33-0316095 | International | CA | $8,327,900Mid-sized | 84.76 |
| Thrive St. LouisEIN 43-1304395 | Health | MO | $2,984,806Small | 87.98 |