| Santa Barbara Opera AssociationEIN 77-0347413 | Arts, Culture, Humanities | CA | $1,636,380Small | 72.64 |
| Save Our Wild SalmonEIN 91-1673170 | Animals | WA | $219,201Small | 77.10 |
| Save Our YouthEIN 84-1295393 | Human Services | CO | $1,378,599Small | 72.08 |
| Second Amendment FoundationEIN 91-6184167 | Human and Civil Rights | WA | $4,129,021Mid-sized | 74.92 |
| Second Stage TheatreEIN 13-3021180 | Arts, Culture, Humanities | NY | $9,254,856Mid-sized | 77.08 |
| SECOREIN 20-4226894 | Human Services | CO | $4,048,217Mid-sized | 72.61 |
| Securing America's Future EnergyEIN 20-1727977 | Research and Public Policy | DC | $6,080,643Mid-sized | 74.06 |
| Seeds of PeaceEIN 52-1814447 | International | NY | $5,723,593Mid-sized | 79.84 |
| Serviam Girls AcademyEIN 26-0792594 | Education | DE | $864,712Small | 70.00 |
| Sharon Lynne Wilson Center for the ArtsEIN 39-1787648 | Arts, Culture, Humanities | WI | $2,952,831Small | 78.38 |
| Show HopeEIN 32-0011220 | Human Services | TN | $10,019,254Mid-sized | 77.30 |
| Show-Me Christian Youth HomeEIN 43-1861323 | Human Services | MO | $2,080,172Small | 76.44 |
| Shreveport-Bossier Rescue MissionEIN 23-7050551 | Human Services | LA | $2,151,146Small | 77.27 |
| Sierra Nevada AllianceEIN 77-0343881 | Environment | CA | $825,345Small | 79.38 |
| SIFFEIN 91-1489660 | Arts, Culture, Humanities | WA | $6,896,394Mid-sized | 73.81 |
| Sixth & IEIN 33-1036146 | Religion | DC | $3,489,232Small | 77.69 |
| Skylight Music TheatreEIN 39-0975374 | Arts, Culture, Humanities | WI | $3,499,182Small | 78.63 |
| Smoky Hills Public TelevisionEIN 48-0874906 | Arts, Culture, Humanities | KS | $1,840,013Small | 79.50 |
| Soaring EagleEIN 84-1409114 | Human Services | MT | $3,535,909Mid-sized | 79.67 |
| Soil Born Farms Urban Agriculture & Education ProjectEIN 20-0774693 | Education | CA | $1,888,739Small | 79.87 |
| Sojourner CenterEIN 94-2465081 | Human Services | AZ | $7,335,341Mid-sized | 72.33 |
| SoliyaEIN 32-0060209 | International | NY | $1,365,656Small | 72.22 |
| Solomon R. Guggenheim FoundationEIN 13-5562233 | Arts, Culture, Humanities | NY | $80,072,379Large | 78.32 |
| Solutions for ChangeEIN 33-0902617 | Human Services | CA | $3,329,200Small | 79.52 |
| SOLVEEIN 93-0579286 | Environment | OR | $1,209,987Small | 78.43 |
| Sons of Italy FoundationEIN 23-6276526 | Community Development | DC | $991,230Small | 77.48 |
| SonScape RetreatsEIN 74-2372030 | Religion | CO | $1,005,888Small | 73.32 |
| SOS Children's Villages-USAEIN 13-6188433 | International | DC | $10,446,173Mid-sized | 77.68 |
| South Africa Development FundEIN 22-2674813 | International | MA | $904,837Small | 78.60 |
| South Carolina Woman's Missionary UnionEIN 57-0362065 | Religion | SC | $2,531,177Small | 79.42 |
| South Florida PBSEIN 59-0737868 | Arts, Culture, Humanities | FL | $18,553,742Large | 78.65 |
| South Florida Wildlife CenterEIN 23-7086391 | Animals | FL | $3,713,493Mid-sized | 78.77 |
| Southern Partners FundEIN 58-2409301 | Human Services | GA | $1,225,922Small | 77.64 |
| Southwest Christian CareEIN 58-1849504 | Human Services | GA | $2,109,260Small | 73.34 |
| SPARKEIN 54-1498824 | Education | VA | $4,425,085Mid-sized | 78.96 |
| Spay-Neuter Assistance Program, Inc.EIN 76-0608925 | Animals | TX | $5,557,041Mid-sized | 73.07 |
| SPCA InternationalEIN 87-0773320 | Animals | NY | $14,673,812Large | 72.62 |
| Special Olympics IdahoEIN 23-7185185 | Human Services | ID | $789,375Small | 78.93 |
| Special Olympics LouisianaEIN 72-0706608 | Human Services | LA | $1,807,182Small | 76.42 |
| Special Olympics New MexicoEIN 85-0268084 | Human Services | NM | $1,782,183Small | 78.45 |
| Special Olympics OregonEIN 93-0752969 | Human Services | OR | $4,858,280Mid-sized | 73.03 |
| Sports World, Inc.EIN 23-7073822 | Religion | IN | $1,106,989Small | 75.82 |
| Springfield Victory MissionEIN 43-1345089 | Human Services | MO | $2,352,783Small | 79.57 |
| St. Baldrick's FoundationEIN 20-1173824 | Health | CA | $41,680,500Large | 77.72 |
| St. Gerard CampusEIN 59-2483955 | Human Services | FL | $756,996Small | 74.01 |
| St. Louis Public Library FoundationEIN 43-1541947 | Arts, Culture, Humanities | MO | $744,456Small | 79.60 |
| St. Mary's SewaneeEIN 62-1359755 | Religion | TN | $915,612Small | 74.38 |
| Stan Hywet Hall & GardensEIN 34-0819149 | Arts, Culture, Humanities | OH | $5,263,087Mid-sized | 73.90 |
| Stephen's Children FoundationEIN 58-2219199 | International | MI | $1,332,560Small | 71.83 |
| SteppingStone TheatreEIN 36-3557115 | Education | MN | $871,063Small | 79.18 |
| Stevens-Swan Humane Society of Oneida CountyEIN 15-0551485 | Animals | NY | $1,087,872Small | 77.21 |
| Storefront Academy HarlemEIN 13-2940671 | Education | NY | $3,785,092Mid-sized | 79.48 |
| Suffolk County Police Athletic LeagueEIN 23-7356002 | Human Services | NY | $1,095,091Small | 76.76 |
| Summer Camp Opportunities Promote Education (SCOPE)EIN 20-2772242 | Education | NY | $713,151Small | 72.80 |
| Summer SearchEIN 68-0200138 | Education | CA | $18,984,959Large | 79.19 |
| Summit Speech SchoolEIN 22-1829502 | Education | NJ | $4,019,719Mid-sized | 75.56 |
| Sunday Breakfast MissionEIN 51-0073080 | Human Services | DE | $5,615,126Mid-sized | 79.65 |
| Sunday Breakfast Rescue MissionEIN 23-1352558 | Human Services | PA | $3,017,157Small | 79.81 |
| Sunshine MinistriesEIN 43-0896665 | Human Services | MO | $1,553,900Small | 79.61 |
| Support Circle Pregnancy ClinicsEIN 94-2937281 | Health | CA | $1,470,007Small | 76.06 |