| American Skin AssociationEIN 13-3401320 | Health | NY | $1,405,914Small | 92.92 |
| American Society for the Protection of Nature in IsraelEIN 52-1467954 | Animals | NY | $1,822,784Small | 91.16 |
| American Society for Yad VashemEIN 13-3106768 | Arts, Culture, Humanities | NY | $16,168,788Large | 92.22 |
| American Society of TransplantationEIN 42-1182936 | Health | NJ | $4,846,825Mid-sized | 90.68 |
| American Technion SocietyEIN 13-0434195 | Education | NY | $102,913,014Large | 93.52 |
| American Thyroid AssociationEIN 41-6038600 | Health | VA | $2,874,645Small | 91.42 |
| American Veterinary Medical FoundationEIN 36-6117739 | Animals | IL | $2,053,777Small | 92.38 |
| American WhitewaterEIN 23-7083760 | Environment | NC | $1,302,577Small | 92.22 |
| American Youth FoundationEIN 43-0652614 | Human Services | MO | $6,196,477Mid-sized | 92.39 |
| American Youth Policy ForumEIN 31-1576455 | Research and Public Policy | DC | $1,439,978Small | 91.69 |
| American-Scandinavian FoundationEIN 13-1623897 | International | NY | $4,819,474Mid-sized | 91.67 |
| Americans for the ArtsEIN 52-1996467 | Arts, Culture, Humanities | DC | $16,084,664Large | 91.45 |
| AmericaresEIN 06-1008595 | International | CT | $1,927,303,882Large | 97.87 |
| Amigos for ChristEIN 58-2484257 | International | GA | $13,425,711Mid-sized | 100.00 |
| Amigos For KidsEIN 65-0361629 | Human Services | FL | $1,912,759Small | 91.36 |
| AMITEIN 13-5631502 | Education | NY | $10,330,407Mid-sized | 93.35 |
| Anacostia Watershed SocietyEIN 52-1666511 | Environment | MD | $3,962,805Mid-sized | 90.58 |
| And Justice for AllEIN 87-0659915 | Human and Civil Rights | UT | $2,318,717Small | 92.22 |
| Anderson Animal ShelterEIN 36-6164626 | Animals | IL | $2,677,397Small | 94.45 |
| Andrew Wommack MinistriesEIN 84-0780017 | Religion | CO | $47,946,843Large | 96.32 |
| AneraEIN 52-0882226 | International | DC | $68,483,582Large | 92.56 |
| Angel Flight NortheastEIN 04-3314346 | Health | MA | $831,086Small | 90.04 |
| Angel Flight WestEIN 95-3956297 | Health | CA | $8,131,490Mid-sized | 91.36 |
| Angelman Syndrome FoundationEIN 59-3092842 | Health | IL | $2,446,564Small | 90.57 |
| Animal Defense League of TexasEIN 74-6002033 | Animals | TX | $5,059,654Mid-sized | 97.86 |
| Animal FriendsEIN 25-0951565 | Animals | PA | $6,341,173Mid-sized | 91.34 |
| Animal Humane New MexicoEIN 85-0207652 | Animals | NM | $6,189,256Mid-sized | 94.47 |
| Animal Legal Defense FundEIN 94-2681680 | Animals | CA | $12,487,558Mid-sized | 93.04 |
| Animal Protective Association of MissouriEIN 43-0699783 | Animals | MO | $2,515,712Small | 92.72 |
| Animal Rescue Fund of the HamptonsEIN 23-7400663 | Animals | NY | $4,545,405Mid-sized | 94.58 |
| Animal Rescue League of Berks County, Inc.EIN 23-1417505 | Animals | PA | $2,025,484Small | 91.92 |
| Animal Rescue League of IowaEIN 42-0680427 | Animals | IA | $5,904,398Mid-sized | 91.39 |
| Animal Welfare AssociationEIN 22-1752792 | Animals | NJ | $3,186,672Small | 91.71 |
| Animal Welfare InstituteEIN 13-5655952 | Animals | DC | $2,737,309Small | 92.92 |
| Animal Welfare LeagueEIN 36-2235155 | Animals | IL | $6,855,668Mid-sized | 91.39 |
| Animal Welfare League of AlexandriaEIN 54-0796610 | Animals | VA | $2,882,177Small | 90.45 |
| Animal Welfare League of ArlingtonEIN 54-0603502 | Animals | VA | $3,195,704Small | 91.63 |
| Animal Welfare SocietyEIN 23-7018176 | Animals | ME | $3,126,373Small | 95.22 |
| Anita Borg InstituteEIN 77-0480427 | Education | CA | $19,390,962Large | 92.66 |
| Any Baby Can of San AntonioEIN 74-2684333 | Health | TX | $3,063,243Small | 90.32 |
| Aplastic Anemia & MDS International FoundationEIN 52-1336903 | Health | MD | $6,448,619Mid-sized | 91.51 |
| Appalachia Service ProjectEIN 62-0989383 | Community Development | TN | $11,166,665Mid-sized | 92.92 |
| Appalachian Mountain ClubEIN 04-6001677 | Environment | MA | $31,787,810Large | 95.87 |
| Appalachian Trail ConservancyEIN 52-6046689 | Environment | WV | $9,331,050Mid-sized | 94.19 |
| Appalachian VoicesEIN 56-2049956 | Environment | NC | $2,237,713Small | 100.00 |
| Aquarium of the PacificEIN 33-0532354 | Animals | CA | $31,141,128Large | 91.67 |
| Arby's FoundationEIN 58-1692997 | Human Services | GA | $8,124,464Mid-sized | 94.58 |
| Archaeological ConservancyEIN 95-3403273 | Arts, Culture, Humanities | NM | $3,693,315Mid-sized | 96.66 |
| Archaeology SouthwestEIN 86-0640183 | Arts, Culture, Humanities | AZ | $1,591,501Small | 92.92 |
| Arizona Animal Welfare League & SPCAEIN 23-7149453 | Animals | AZ | $4,398,395Mid-sized | 93.87 |
| Arizona Christian School Tuition OrganizationEIN 86-0931047 | Education | AZ | $19,281,533Large | 91.05 |
| Arizona Community FoundationEIN 86-0348306 | Community Development | AZ | $67,913,276Large | 92.98 |
| Arizona Humane SocietyEIN 86-0135567 | Animals | AZ | $18,373,050Large | 90.64 |
| Arizona Private Education Scholarship FundEIN 86-0958161 | Education | AZ | $6,349,350Mid-sized | 94.74 |
| Arkansas FoodbankEIN 71-0596734 | Human Services | AR | $43,348,876Large | 90.22 |
| Arlington Food Assistance CenterEIN 54-1473207 | Human Services | VA | $5,583,702Mid-sized | 96.40 |
| Arlington Free ClinicEIN 54-1671883 | Health | VA | $4,036,752Mid-sized | 90.45 |
| Arlington Street People's Assistance NetworkEIN 54-1615993 | Human Services | VA | $4,004,806Mid-sized | 90.58 |
| Arm In ArmEIN 22-3198464 | Human Services | NJ | $2,461,297Small | 95.29 |
| Armed Services YMCAEIN 36-3274346 | Human Services | VA | $22,350,334Large | 93.12 |