| Hillel: The Foundation for Jewish Campus LifeEIN 52-1844823 | Religion | DC | $44,307,034Large | 86.43 |
| Hinds HospiceEIN 77-0071360 | Human Services | CA | $17,071,457Large | 88.26 |
| Hispanic FederationEIN 13-3573852 | Human Services | NY | $22,920,477Large | 93.91 |
| Hispanic Scholarship FundEIN 52-1051044 | Education | CA | $48,536,245Large | 89.06 |
| Historic New EnglandEIN 04-2104937 | Arts, Culture, Humanities | MA | $14,637,738Large | 92.21 |
| Hoag Hospital FoundationEIN 95-3222343 | Health | CA | $29,764,586Large | 82.25 |
| Holt International Children's ServicesEIN 23-7257390 | Human Services | OR | $25,692,316Large | 80.79 |
| Home of the InnocentsEIN 61-0445834 | Human Services | KY | $39,082,992Large | 90.87 |
| Homeboy IndustriesEIN 95-4800735 | Human Services | CA | $14,246,173Large | 81.86 |
| Homes For Our TroopsEIN 54-2143612 | Human Services | MA | $26,786,156Large | 89.76 |
| Honolulu Museum of ArtEIN 99-0079713 | Arts, Culture, Humanities | HI | $15,092,443Large | 85.23 |
| Hope for HaitiEIN 59-3564329 | International | FL | $24,552,991Large | 97.17 |
| HOPE InternationalEIN 23-2836648 | International | PA | $16,207,811Large | 91.41 |
| HOPE worldwideEIN 04-3129839 | International | CA | $21,961,902Large | 91.55 |
| Horatio Alger Association of Distinguished AmericansEIN 13-1669975 | Education | VA | $29,499,682Large | 92.38 |
| Hosanna/Faith Comes By HearingEIN 85-0223225 | Religion | NM | $17,163,576Large | 95.89 |
| Houston BalletEIN 74-1394920 | Arts, Culture, Humanities | TX | $34,183,785Large | 96.63 |
| Houston Food BankEIN 74-2181456 | Human Services | TX | $204,124,432Large | 97.10 |
| Houston Museum of Natural ScienceEIN 74-1036131 | Arts, Culture, Humanities | TX | $35,434,393Large | 88.66 |
| Houston Parks BoardEIN 74-1860046 | Environment | TX | $22,107,401Large | 94.34 |
| Houston Public Media FoundationEIN 74-1670740 | Arts, Culture, Humanities | TX | $15,686,987Large | 89.28 |
| Houston ZooEIN 74-1590271 | Animals | TX | $48,461,175Large | 95.47 |
| Howard Brown Health CenterEIN 36-2894128 | Health | IL | $68,173,341Large | 92.61 |
| Hudson InstituteEIN 13-1945157 | International | DC | $14,882,370Large | 91.87 |
| Human Rights Campaign FoundationEIN 52-1481896 | Human and Civil Rights | DC | $16,850,495Large | 84.29 |
| Human Rights WatchEIN 13-2875808 | International | NY | $70,558,186Large | 85.82 |
| Humane Society InternationalEIN 52-1769464 | Animals | DC | $14,265,429Large | 87.97 |
| Humane Society of MissouriEIN 43-0652638 | Animals | MO | $19,333,513Large | 91.59 |
| Hunger Task ForceEIN 39-1345847 | Human Services | WI | $16,848,662Large | 89.56 |
| Huntington Theatre CompanyEIN 22-2659560 | Arts, Culture, Humanities | MA | $14,175,401Large | 86.60 |
| ICNA Relief USAEIN 04-3810161 | Human Services | NY | $14,885,429Large | 95.47 |
| Idaho FoodbankEIN 82-0425400 | Human Services | ID | $35,648,299Large | 93.48 |
| Idaho Youth RanchEIN 82-0253346 | Human Services | ID | $23,775,946Large | 91.16 |
| Idyllwild Arts FoundationEIN 95-1801279 | Education | CA | $26,431,187Large | 81.19 |
| IMA World HealthEIN 52-2112460 | International | DC | $97,151,816Large | 82.32 |
| iMentorEIN 30-0105507 | Education | NY | $18,667,266Large | 90.00 |
| In Touch MinistriesEIN 58-1495310 | Religion | GA | $92,027,999Large | 86.14 |
| Indianapolis Symphony OrchestraEIN 35-0998627 | Arts, Culture, Humanities | IN | $23,290,238Large | 78.59 |
| Indianapolis ZooEIN 35-1074747 | Animals | IN | $32,985,416Large | 88.11 |
| InFaith Community FoundationEIN 41-1802412 | Community Development | MN | $27,770,587Large | 89.55 |
| Inner-City Scholarship FundEIN 51-0453629 | Education | NY | $17,315,161Large | 88.90 |
| Insight for LivingEIN 95-3392299 | Religion | TX | $19,580,163Large | 82.54 |
| Institute for Humane StudiesEIN 94-1623852 | Education | VA | $18,238,447Large | 83.65 |
| Institute for JusticeEIN 52-1744337 | Human and Civil Rights | VA | $22,312,263Large | 97.70 |
| Institute of International EducationEIN 13-1624046 | International | NY | $358,197,642Large | 83.33 |
| Inter-Faith Food ShuttleEIN 56-1753180 | Human Services | NC | $13,594,451Large | 82.98 |
| Interfaith Ministries for Greater HoustonEIN 74-1488102 | Human Services | TX | $17,732,074Large | 96.13 |
| Interlochen Center for the ArtsEIN 38-1689022 | Education | MI | $55,453,968Large | 86.94 |
| International AIDS Vaccine InitiativeEIN 13-3870223 | Health | NY | $85,397,465Large | 92.92 |
| International Center of PhotographyEIN 23-7412428 | Arts, Culture, Humanities | NY | $17,276,229Large | 81.79 |
| International Children's FundEIN 39-1303430 | International | WI | $51,113,670Large | 92.27 |
| International Cooperating MinistriesEIN 54-6338714 | Religion | VA | $23,865,869Large | 96.46 |
| International Fellowship of Christians and JewsEIN 36-3256096 | International | IL | $134,425,717Large | 85.68 |
| International Fund for Animal WelfareEIN 31-1594197 | Animals | MA | $23,001,672Large | 80.88 |
| International HouseEIN 13-1624048 | International | NY | $16,690,286Large | 88.41 |
| International Justice MissionEIN 54-1722887 | International | DC | $64,086,117Large | 87.44 |
| International Medical CorpsEIN 95-3949646 | International | CA | $138,130,256Large | 84.22 |
| International Myeloma FoundationEIN 95-4296919 | Health | CA | $16,025,421Large | 92.92 |
| International Orthodox Christian CharitiesEIN 25-1679348 | International | MD | $40,613,412Large | 85.85 |
| International Planned Parenthood Federation/Western Hemisphere RegionEIN 13-1845455 | Health | NY | $29,392,929Large | 93.32 |