| The Centers for Families and ChildrenEIN 23-7084455 | Human Services | OH | $39,184,196Large | 90.58 |
| The Chicago Council on Global AffairsEIN 36-2181969 | International | IL | $16,806,570Large | 94.08 |
| The Chicago LighthouseEIN 36-2169139 | Human Services | IL | $37,488,861Large | 92.32 |
| The Children's Clinic, Serving Children and Their FamiliesEIN 95-1643332 | Health | CA | $31,229,655Large | 91.32 |
| The Christian Broadcasting NetworkEIN 54-0678752 | Religion | VA | $319,708,060Large | 88.20 |
| The Cleveland FoundationEIN 34-0714588 | Community Development | OH | $104,350,367Large | 91.70 |
| The Cleveland Museum of ArtEIN 34-0714336 | Arts, Culture, Humanities | OH | $60,688,211Large | 88.50 |
| The Cleveland OrchestraEIN 34-0714468 | Arts, Culture, Humanities | OH | $55,320,592Large | 81.92 |
| The Climate Reality ProjectEIN 87-0745629 | Environment | DC | $16,685,214Large | 88.37 |
| The Clinton FoundationEIN 31-1580204 | International | NY | $227,328,658Large | 92.40 |
| The Columbus FoundationEIN 31-6044264 | Community Development | OH | $175,866,285Large | 95.05 |
| The Community Foundation for Greater AtlantaEIN 58-1344646 | Community Development | GA | $121,717,288Large | 90.99 |
| The Community Foundation for Northeast FloridaEIN 59-6150746 | Community Development | FL | $41,921,959Large | 93.74 |
| The Community Foundation of LouisvilleEIN 31-0997017 | Community Development | KY | $54,954,721Large | 96.46 |
| The Community Foundation of Sarasota CountyEIN 59-1956886 | Community Development | FL | $38,090,969Large | 91.34 |
| The Community Foundation of Western North CarolinaEIN 56-1223384 | Community Development | NC | $17,373,488Large | 90.07 |
| The Community Foundation Serving Richmond and Central VirginiaEIN 23-7009135 | Community Development | VA | $40,927,134Large | 92.25 |
| The Conservation FundEIN 52-1388917 | Environment | VA | $274,566,587Large | 96.46 |
| The Council of State GovernmentsEIN 36-6000818 | Research and Public Policy | KY | $39,651,190Large | 80.51 |
| The Dallas Arboretum and Botanical SocietyEIN 23-7375815 | Environment | TX | $24,493,663Large | 92.50 |
| The Dallas OperaEIN 75-6004746 | Arts, Culture, Humanities | TX | $18,462,712Large | 92.71 |
| The Dayton FoundationEIN 31-6027287 | Community Development | OH | $27,126,725Large | 83.65 |
| The Denver FoundationEIN 84-6048381 | Community Development | CO | $81,071,246Large | 90.42 |
| The Detroit Institute of ArtsEIN 38-1359510 | Arts, Culture, Humanities | MI | $40,056,968Large | 89.52 |
| The Educational AllianceEIN 13-5562210 | Human Services | NY | $41,828,233Large | 91.75 |
| The Family ConservancyEIN 44-0454800 | Human Services | KS | $13,903,035Large | 87.04 |
| The Federalist Society for Law and Public Policy StudiesEIN 36-3235550 | Research and Public Policy | DC | $18,233,577Large | 92.22 |
| The Field MuseumEIN 36-2167011 | Arts, Culture, Humanities | IL | $80,404,720Large | 90.93 |
| The Florida AquariumEIN 59-2807815 | Animals | FL | $18,265,885Large | 90.00 |
| The Food Bank for Central & Northeast MissouriEIN 43-1238934 | Human Services | MO | $58,016,683Large | 89.63 |
| The Food Bank of Western MassachusettsEIN 04-2751023 | Human Services | MA | $16,036,784Large | 90.87 |
| The Foodbank of Southern CaliforniaEIN 95-3557056 | Human Services | CA | $79,360,705Large | 96.46 |
| The Franklin InstituteEIN 23-1370501 | Arts, Culture, Humanities | PA | $39,781,763Large | 90.01 |
| The Fred Rogers CompanyEIN 25-1215087 | Human Services | PA | $22,348,535Large | 92.02 |
| The Free Library of PhiladelphiaEIN 52-1173474 | Arts, Culture, Humanities | PA | $39,234,948Large | 92.74 |
| The Fresh Air FundEIN 13-1656653 | Human Services | NY | $19,122,855Large | 83.47 |
| The Generosity TrustEIN 62-1536731 | Community Development | TN | $22,998,461Large | 95.94 |
| The Goodman TheatreEIN 36-2896025 | Arts, Culture, Humanities | IL | $24,992,342Large | 84.10 |
| The Granite YMCAEIN 02-0222248 | Human Services | NH | $17,909,293Large | 93.59 |
| The Greater Boston Food BankEIN 04-2717782 | Human Services | MA | $94,275,916Large | 86.16 |
| The Greater Cincinnati FoundationEIN 31-0669700 | Community Development | OH | $82,431,309Large | 93.72 |
| The Greater New Orleans FoundationEIN 72-0408921 | Community Development | LA | $29,757,031Large | 91.06 |
| The Henry FordEIN 38-1359513 | Arts, Culture, Humanities | MI | $75,344,480Large | 75.71 |
| The Heritage FoundationEIN 23-7327730 | Research and Public Policy | DC | $85,427,198Large | 86.19 |
| The Humane Society of the United StatesEIN 53-0225390 | Animals | DC | $126,131,691Large | 75.49 |
| The Hunger ProjectEIN 94-2443282 | International | NY | $16,822,489Large | 88.33 |
| The Huntington Library, Art Collections, and Botanical GardensEIN 95-1644589 | Arts, Culture, Humanities | CA | $75,523,759Large | 92.00 |
| The Institute for Human ServicesEIN 99-0199107 | Human Services | HI | $14,569,060Large | 80.30 |
| The Institute of Contemporary ArtEIN 04-2104327 | Arts, Culture, Humanities | MA | $15,163,979Large | 87.20 |
| The Ireland Funds AmericaEIN 25-1306992 | International | MA | $33,128,738Large | 91.16 |
| The Jackson LaboratoryEIN 01-0211513 | Health | ME | $335,594,164Large | 95.21 |
| The JCC in ManhattanEIN 13-3490745 | Human Services | NY | $33,977,017Large | 84.31 |
| The Jewish Federation of Greater WashingtonEIN 53-0212445 | Community Development | MD | $29,760,407Large | 88.93 |
| The Jewish MuseumEIN 13-6146854 | Arts, Culture, Humanities | NY | $20,095,013Large | 79.90 |
| The Joffrey BalletEIN 36-4009741 | Arts, Culture, Humanities | IL | $19,599,699Large | 91.61 |
| The John F. Kennedy Center for the Performing ArtsEIN 53-0245017 | Arts, Culture, Humanities | DC | $227,384,468Large | 90.46 |
| The Los Angeles PhilharmonicEIN 95-1696734 | Arts, Culture, Humanities | CA | $130,412,242Large | 93.73 |
| The Lustgarten Foundation for Pancreatic Cancer ResearchEIN 31-1611837 | Health | NY | $22,729,922Large | 100.00 |
| The McGaw YMCAEIN 36-2169194 | Human Services | IL | $17,470,946Large | 89.81 |
| The Minneapolis FoundationEIN 41-6029402 | Community Development | MN | $70,849,060Large | 94.48 |