| The Minneapolis Institute of ArtsEIN 41-0693915 | Arts, Culture, Humanities | MN | $41,681,111Large | 92.05 |
| The Morgan Library & MuseumEIN 13-1624146 | Arts, Culture, Humanities | NY | $25,933,283Large | 87.87 |
| The Morton ArboretumEIN 36-1505770 | Environment | IL | $34,397,968Large | 91.76 |
| The Multiple Myeloma Research FoundationEIN 06-1504413 | Health | CT | $30,536,598Large | 98.23 |
| The Museum of Contemporary Art, Los AngelesEIN 95-3433820 | Arts, Culture, Humanities | CA | $20,004,107Large | 88.87 |
| The Museum of Fine Arts, HoustonEIN 74-1109655 | Arts, Culture, Humanities | TX | $93,408,860Large | 88.15 |
| The Museum of Modern ArtEIN 13-1624100 | Arts, Culture, Humanities | NY | $252,692,693Large | 91.83 |
| The Nature ConservancyEIN 53-0242652 | Environment | VA | $829,488,331Large | 84.06 |
| The New World FoundationEIN 13-1919791 | Human and Civil Rights | NY | $18,406,528Large | 92.22 |
| The New York Botanical GardenEIN 13-1693134 | Environment | NY | $85,186,570Large | 90.56 |
| The New York Public LibraryEIN 13-1887440 | Arts, Culture, Humanities | NY | $341,319,058Large | 91.19 |
| The New-York Historical SocietyEIN 13-1624124 | Arts, Culture, Humanities | NY | $33,697,074Large | 92.75 |
| The Oregon Community FoundationEIN 23-7315673 | Community Development | OR | $116,579,036Large | 96.40 |
| The Paley Center for MediaEIN 13-2805582 | Arts, Culture, Humanities | NY | $20,236,116Large | 83.96 |
| The Philadelphia OrchestraEIN 23-1352289 | Arts, Culture, Humanities | PA | $50,597,401Large | 82.16 |
| The Philadelphia ZooEIN 23-1352298 | Animals | PA | $38,329,612Large | 90.22 |
| The Phillips CollectionEIN 53-0204620 | Arts, Culture, Humanities | DC | $13,559,889Large | 86.75 |
| The Pittsburgh Cultural TrustEIN 25-1469002 | Arts, Culture, Humanities | PA | $60,047,764Large | 89.13 |
| The Pittsburgh FoundationEIN 25-0965466 | Community Development | PA | $58,758,228Large | 91.19 |
| The Posse FoundationEIN 13-3840394 | Education | NY | $22,609,348Large | 89.18 |
| The Public Theater/New York Shakespeare FestivalEIN 13-1844852 | Arts, Culture, Humanities | NY | $43,034,852Large | 89.24 |
| The Rams ClubEIN 56-6058412 | Education | NC | $50,463,082Large | 88.22 |
| The Raymond F. Kravis Center for the Performing ArtsEIN 59-2245054 | Arts, Culture, Humanities | FL | $31,969,350Large | 92.29 |
| The Redwood Empire Food BankEIN 68-0121855 | Human Services | CA | $31,667,737Large | 96.94 |
| The Richard Nixon FoundationEIN 52-1278303 | Arts, Culture, Humanities | CA | $13,772,526Large | 91.36 |
| The Road HomeEIN 87-0212465 | Human Services | UT | $15,310,245Large | 95.30 |
| The Rotary Foundation of Rotary InternationalEIN 36-3245072 | International | IL | $283,724,333Large | 97.51 |
| The SAFE AllianceEIN 74-2320657 | Human Services | TX | $19,434,147Large | 96.37 |
| The Saint Paul FoundationEIN 41-6031510 | Community Development | MN | $76,717,221Large | 93.71 |
| The San Diego FoundationEIN 95-2942582 | Community Development | CA | $62,750,165Large | 86.93 |
| The San Francisco FoundationEIN 01-0679337 | Community Development | CA | $167,683,582Large | 97.17 |
| The San Francisco-Marin Food BankEIN 94-3041517 | Human Services | CA | $95,814,790Large | 91.06 |
| The Santa Fe OperaEIN 85-0131810 | Arts, Culture, Humanities | NM | $26,057,135Large | 86.72 |
| The School of American BalletEIN 13-1275970 | Arts, Culture, Humanities | NY | $15,413,167Large | 89.14 |
| The Scripps Research InstituteEIN 33-0435954 | Health | CA | $366,352,436Large | 90.57 |
| The Seeing EyeEIN 22-1539721 | Animals | NJ | $27,150,791Large | 85.82 |
| The Shalom Hartman Institute of North AmericaEIN 13-3014387 | Education | NY | $16,313,890Large | 91.51 |
| The Society of St. AndrewEIN 54-1285793 | Human Services | VA | $15,925,960Large | 87.66 |
| The Society of St. Vincent de Paul GeorgiaEIN 58-0967972 | Human Services | GA | $15,390,829Large | 89.52 |
| The Tech Museum of InnovationEIN 94-2864660 | Arts, Culture, Humanities | CA | $19,542,724Large | 94.26 |
| The Toledo ZooEIN 34-4440256 | Animals | OH | $32,785,728Large | 92.16 |
| The United Way of Southwestern PennsylvaniaEIN 25-1043578 | Community Development | PA | $37,508,330Large | 93.98 |
| The V FoundationEIN 13-3705951 | Health | NC | $27,693,120Large | 94.69 |
| The Wild Animal SanctuaryEIN 84-1351483 | Animals | CO | $14,203,892Large | 92.38 |
| The Wilderness SocietyEIN 53-0167933 | Environment | DC | $31,030,390Large | 89.71 |
| The Winston-Salem FoundationEIN 56-6037615 | Community Development | NC | $43,190,146Large | 99.79 |
| The Woodruff Arts CenterEIN 58-0633971 | Arts, Culture, Humanities | GA | $96,220,136Large | 87.65 |
| The YMCA of Columbia-WillametteEIN 93-0386981 | Human Services | OR | $26,372,084Large | 91.02 |
| Theatre Under The StarsEIN 74-1621647 | Arts, Culture, Humanities | TX | $17,408,127Large | 87.85 |
| Think SmallEIN 41-1260581 | Human Services | MN | $34,542,069Large | 88.29 |
| Thomas Jefferson FoundationEIN 54-0505959 | Arts, Culture, Humanities | VA | $31,701,531Large | 91.32 |
| Thompson Child & Family FocusEIN 56-0547460 | Human Services | NC | $15,157,223Large | 81.11 |
| Three SquareEIN 30-0396918 | Human Services | NV | $84,710,940Large | 97.23 |
| Thru the Bible Radio NetworkEIN 95-6145276 | Religion | CA | $20,313,129Large | 86.33 |
| Thurgood Marshall College FundEIN 41-1750692 | Education | DC | $22,162,863Large | 92.15 |
| Tides CenterEIN 94-3213100 | Community Development | CA | $110,657,162Large | 96.28 |
| Tiger Athletic FoundationEIN 72-1004960 | Human Services | LA | $36,937,190Large | 90.45 |
| Tigers Unlimited FoundationEIN 36-4538203 | Human Services | AL | $37,400,685Large | 89.91 |
| Tipping Point CommunityEIN 20-2121739 | Human Services | CA | $32,110,248Large | 92.21 |
| Toledo Northwestern Ohio Food Bank, Inc.EIN 34-1441016 | Human Services | OH | $19,677,280Large | 95.05 |