| St. Baldrick's FoundationEIN 20-1173824 | Health | CA | $41,680,500Large | 77.72 |
| St. Boniface Haiti FoundationEIN 04-3067595 | International | MA | $22,333,400Large | 95.87 |
| St. Joseph CenterEIN 95-3874381 | Human Services | CA | $15,753,740Large | 91.58 |
| St. Louis Area FoodbankEIN 43-1253102 | Human Services | MO | $81,514,749Large | 98.86 |
| St. Mary's Food Bank AllianceEIN 23-7353532 | Human Services | AZ | $160,093,972Large | 93.07 |
| St. Patrick CenterEIN 43-1263499 | Human Services | MO | $16,391,436Large | 85.08 |
| St. Vincent de Paul DetroitEIN 38-1359592 | Human Services | MI | $15,821,834Large | 89.01 |
| St. Vincent de Paul of BaltimoreEIN 52-0597056 | Human Services | MD | $20,808,081Large | 94.18 |
| St. Vincent de Paul VillageEIN 33-0492302 | Human Services | CA | $31,913,973Large | 81.26 |
| Stand for Children Leadership CenterEIN 52-1957214 | Education | OR | $15,543,445Large | 90.22 |
| Star of Hope MissionEIN 74-1152599 | Human Services | TX | $29,007,530Large | 86.35 |
| Starkey Hearing FoundationEIN 36-3297852 | Human Services | MN | $21,659,389Large | 92.82 |
| State VoicesEIN 20-1115618 | Human and Civil Rights | DC | $13,763,270Large | 94.07 |
| Statue of Liberty-Ellis Island FoundationEIN 13-3118415 | Arts, Culture, Humanities | NY | $18,817,780Large | 92.24 |
| Step Up For StudentsEIN 59-3649371 | Education | FL | $674,603,917Large | 96.66 |
| Stephen Siller Tunnel to Towers FoundationEIN 02-0554654 | Human Services | NY | $16,641,583Large | 98.23 |
| Strategic Resource GroupEIN 33-0780945 | Religion | MD | $17,558,750Large | 83.56 |
| Student Conservation Association EIN 91-0880684 | Environment | VA | $43,289,688Large | 89.65 |
| Student MobilizationEIN 71-0629392 | Religion | AR | $13,955,451Large | 83.56 |
| Sulzbacher CenterEIN 59-3229898 | Human Services | FL | $14,566,080Large | 92.02 |
| Summer SearchEIN 68-0200138 | Education | CA | $18,984,959Large | 79.19 |
| Sundance InstituteEIN 87-0361394 | Arts, Culture, Humanities | CA | $42,985,822Large | 88.22 |
| Susan G. Komen for the CureEIN 75-1835298 | Health | TX | $182,911,053Large | 80.87 |
| SynergosEIN 13-3392006 | International | NY | $14,088,067Large | 93.42 |
| Table to TableEIN 22-3646125 | Human Services | NJ | $26,205,578Large | 98.23 |
| Tampa Metropolitan Area YMCAEIN 59-1742909 | Human Services | FL | $33,632,520Large | 92.49 |
| Tarrant Area Food BankEIN 75-1822473 | Human Services | TX | $61,702,181Large | 94.77 |
| TB AllianceEIN 13-4128413 | Health | NY | $54,033,661Large | 95.64 |
| Teach For AmericaEIN 13-3541913 | Education | NY | $287,132,584Large | 88.00 |
| TechnoServeEIN 13-2626135 | International | VA | $85,806,073Large | 86.73 |
| Tennyson Center for ChildrenEIN 61-1458290 | Human Services | CO | $13,684,410Large | 91.30 |
| Teton Science SchoolsEIN 83-0219163 | Environment | WY | $14,782,834Large | 90.70 |
| Texas Heart InstituteEIN 74-6053200 | Health | TX | $35,589,463Large | 77.25 |
| Texas State AquariumEIN 23-7044950 | Animals | TX | $14,727,252Large | 92.93 |
| The 92nd Street YEIN 13-1624229 | Human Services | NY | $69,602,246Large | 88.59 |
| The Academy of Natural Sciences of Drexel UniversityEIN 23-1352000 | Arts, Culture, Humanities | PA | $20,069,886Large | 88.54 |
| The Action CenterEIN 23-7019679 | Human Services | CO | $13,852,593Large | 86.81 |
| The Actors FundEIN 13-1635251 | Arts, Culture, Humanities | NY | $34,504,429Large | 92.52 |
| The Albertsons Companies FoundationEIN 91-2144510 | Community Development | CA | $46,816,024Large | 81.61 |
| The ALS Association, National OfficeEIN 13-3271855 | Health | DC | $37,818,211Large | 95.21 |
| The Alumni Association of the University of VirginiaEIN 54-0485595 | Education | VA | $67,343,625Large | 91.33 |
| The American Congress of Obstetricians and GynecologistsEIN 36-2217981 | Health | DC | $41,598,166Large | 84.20 |
| The Animal Medical CenterEIN 13-5505367 | Animals | NY | $47,432,319Large | 87.71 |
| The Art Institute of ChicagoEIN 36-2167725 | Education | IL | $315,496,942Large | 89.06 |
| The Asia FoundationEIN 94-1191246 | International | CA | $104,446,388Large | 84.09 |
| The Aspen InstituteEIN 84-0399006 | Research and Public Policy | DC | $136,995,834Large | 94.32 |
| The Associated: Jewish Community Federation of BaltimoreEIN 52-0607957 | Community Development | MD | $89,648,387Large | 97.17 |
| The Atlanta Botanical GardenEIN 58-1313284 | Environment | GA | $22,065,406Large | 93.53 |
| The Atlantic Council of the United StatesEIN 52-0742294 | International | DC | $27,655,974Large | 94.74 |
| The Baltimore Museum of ArtEIN 52-6000162 | Arts, Culture, Humanities | MD | $17,359,755Large | 87.35 |
| The Barnes FoundationEIN 23-6000149 | Arts, Culture, Humanities | PA | $24,358,404Large | 89.61 |
| The Billings Food BankEIN 36-3519470 | Human Services | MT | $33,211,664Large | 90.30 |
| The Boston FoundationEIN 04-2104021 | Community Development | MA | $157,948,534Large | 96.35 |
| The Bowery MissionEIN 13-1617086 | Human Services | NY | $16,832,525Large | 87.74 |
| The Brookings InstitutionEIN 53-0196577 | Research and Public Policy | DC | $100,059,312Large | 83.36 |
| The Brookwood CommunityEIN 74-1587672 | Education | TX | $22,501,882Large | 89.71 |
| The Bulldog ClubEIN 51-0163622 | Education | MS | $24,916,153Large | 70.09 |
| The BushnellEIN 06-0662112 | Arts, Culture, Humanities | CT | $20,725,995Large | 87.84 |
| The Carter CenterEIN 58-1454716 | International | GA | $326,263,284Large | 97.87 |
| The Center for Strategic and International StudiesEIN 52-1501082 | International | DC | $46,332,597Large | 88.94 |