| Project HOPEEIN 53-0242962 | International | VA | $99,239,752Large | 83.84 |
| Project Lead The WayEIN 14-1816385 | Education | IN | $40,239,525Large | 86.60 |
| ProPublicaEIN 14-2007220 | Arts, Culture, Humanities | NY | $18,290,801Large | 97.17 |
| Public Broadcasting AtlantaEIN 58-2126423 | Arts, Culture, Humanities | GA | $14,307,213Large | 82.15 |
| Public Radio InternationalEIN 41-1425271 | Arts, Culture, Humanities | MN | $18,690,872Large | 85.20 |
| Purple Heart FoundationEIN 59-3184919 | Human Services | VA | $32,780,857Large | 28.59 |
| Radio Training NetworkEIN 58-1585542 | Religion | SC | $18,872,250Large | 68.18 |
| Rainforest AllianceEIN 13-3377893 | Environment | NY | $39,968,460Large | 79.81 |
| Rainforest TrustEIN 13-3500609 | Environment | VA | $16,200,766Large | 94.69 |
| RAND CorporationEIN 95-1958142 | Research and Public Policy | CA | $339,414,517Large | 83.79 |
| RareEIN 23-7380563 | Environment | VA | $25,106,435Large | 92.29 |
| Ravinia FestivalEIN 36-6002273 | Arts, Culture, Humanities | IL | $42,396,239Large | 90.24 |
| RawhideEIN 39-1052471 | Human Services | WI | $14,606,304Large | 96.91 |
| Razorback FoundationEIN 71-0540644 | Education | AR | $34,102,926Large | 89.38 |
| Reading PartnersEIN 77-0568469 | Education | CA | $28,959,670Large | 84.56 |
| Regional Food Bank of OklahomaEIN 73-1100380 | Human Services | OK | $84,517,598Large | 92.65 |
| Relevant RadioEIN 39-2003067 | Religion | WI | $14,340,533Large | 89.16 |
| Rescue Mission, SyracuseEIN 15-0532146 | Human Services | NY | $21,139,953Large | 84.75 |
| Resources for the FutureEIN 53-0220900 | Environment | DC | $13,755,089Large | 89.69 |
| Rheumatology Research FoundationEIN 58-1654301 | Health | GA | $14,033,568Large | 92.22 |
| Rhode Island Community Food BankEIN 05-0395601 | Human Services | RI | $16,275,074Large | 84.89 |
| Riley Children's FoundationEIN 35-0868147 | Health | IN | $46,249,962Large | 88.83 |
| Rise Against HungerEIN 16-1541024 | International | NC | $49,757,061Large | 91.16 |
| River Bend FoodbankEIN 36-3147342 | Human Services | IA | $25,107,770Large | 98.23 |
| Roadrunner Food Bank of New MexicoEIN 85-0278525 | Human Services | NM | $61,893,675Large | 89.57 |
| Robin Hood FoundationEIN 13-3441066 | Community Development | NY | $209,989,218Large | 94.26 |
| Rocky Mountain Elk FoundationEIN 81-0421425 | Animals | MT | $41,006,222Large | 88.07 |
| Rocky Mountain InstituteEIN 74-2244146 | Environment | CO | $33,402,821Large | 94.57 |
| Rocky Mountain PBSEIN 84-0510785 | Arts, Culture, Humanities | CO | $16,052,005Large | 79.06 |
| Ronald McDonald House CharitiesEIN 36-2934689 | Health | IL | $39,981,206Large | 92.82 |
| Ronald Reagan Presidential FoundationEIN 77-0054631 | Arts, Culture, Humanities | CA | $23,845,811Large | 88.34 |
| Room to ReadEIN 91-2003533 | International | CA | $53,102,212Large | 92.92 |
| Root CapitalEIN 04-3478123 | International | MA | $29,771,735Large | 92.38 |
| Roswell Park Alliance FoundationEIN 16-1391608 | Health | NY | $20,082,219Large | 95.63 |
| Roundabout Theatre CompanyEIN 13-6192346 | Arts, Culture, Humanities | NY | $68,732,912Large | 96.18 |
| Saban Community ClinicEIN 95-2539105 | Health | CA | $22,618,402Large | 93.91 |
| Sacramento Food Bank & Family ServicesEIN 94-3315566 | Human Services | CA | $42,378,801Large | 88.81 |
| Sacred Heart Community ServiceEIN 23-7179787 | Human Services | CA | $22,848,309Large | 93.77 |
| Saint Louis Symphony OrchestraEIN 43-0666769 | Arts, Culture, Humanities | MO | $30,010,463Large | 86.41 |
| Saint Louis Zoo AssociationEIN 43-1727309 | Animals | MO | $16,950,536Large | 91.13 |
| Salk Institute for Biological StudiesEIN 95-2160097 | Health | CA | $119,364,264Large | 91.35 |
| Salvadoran American Humanitarian FoundationEIN 59-2339140 | International | FL | $25,123,269Large | 94.69 |
| Samaritan's PurseEIN 58-1437002 | International | NC | $595,259,892Large | 95.85 |
| San Antonio Food BankEIN 74-2122979 | Human Services | TX | $129,142,157Large | 95.96 |
| San Diego Humane Society EIN 95-1661688 | Animals | CA | $25,491,250Large | 92.49 |
| San Diego Rescue MissionEIN 95-1874073 | Human Services | CA | $19,785,817Large | 86.04 |
| San Diego Symphony OrchestraEIN 95-2040874 | Arts, Culture, Humanities | CA | $26,040,490Large | 93.01 |
| San Diego Zoo GlobalEIN 95-1648219 | Animals | CA | $263,690,859Large | 92.36 |
| San Francisco AIDS FoundationEIN 94-2927405 | Health | CA | $31,653,409Large | 92.19 |
| San Francisco BalletEIN 94-1415298 | Arts, Culture, Humanities | CA | $50,771,268Large | 82.83 |
| San Francisco Museum of Modern ArtEIN 94-1156300 | Arts, Culture, Humanities | CA | $86,111,301Large | 85.61 |
| San Francisco OperaEIN 94-0836240 | Arts, Culture, Humanities | CA | $77,826,840Large | 87.05 |
| San Francisco Parks AllianceEIN 23-7131784 | Environment | CA | $15,142,255Large | 92.48 |
| San Francisco SPCAEIN 94-0836580 | Animals | CA | $37,358,567Large | 95.47 |
| San Francisco ZooEIN 94-1429538 | Animals | CA | $24,928,934Large | 84.00 |
| Sanctuary for FamiliesEIN 13-3193119 | Human Services | NY | $21,026,926Large | 92.24 |
| Santa Barbara FoundationEIN 95-1866094 | Community Development | CA | $32,703,267Large | 95.50 |
| Santa Barbara Neighborhood ClinicsEIN 77-0496382 | Health | CA | $14,396,726Large | 91.45 |
| Save the ChildrenEIN 06-0726487 | International | CT | $719,647,258Large | 85.21 |
| SBPEIN 26-2189665 | Human Services | LA | $15,115,618Large | 95.12 |