| Akshaya Patra USAEIN 01-0574950 | International | MA | $5,191,642Mid-sized | 91.05 |
| Alabama Shakespeare FestivalEIN 63-0652734 | Arts, Culture, Humanities | AL | $8,281,994Mid-sized | 80.70 |
| Alabama Symphony OrchestraEIN 63-1103036 | Arts, Culture, Humanities | AL | $7,077,881Mid-sized | 79.08 |
| Alexander Muss Institute for Israel EducationEIN 59-0173782 | International | NY | $9,477,262Mid-sized | 95.48 |
| Alfalit InternationalEIN 59-1595459 | International | FL | $4,142,770Mid-sized | 88.31 |
| All About Developmental DisabilitiesEIN 58-0641496 | Human Services | GA | $4,265,976Mid-sized | 86.76 |
| All Classical PortlandEIN 93-1042868 | Arts, Culture, Humanities | OR | $3,780,565Mid-sized | 92.79 |
| All God's Children InternationalEIN 93-1052909 | International | WA | $4,419,370Mid-sized | 89.39 |
| All Hands and Hearts Smart ResponseEIN 20-3414952 | Human Services | MA | $6,086,763Mid-sized | 98.23 |
| All Hands RaisedEIN 93-1149789 | Education | OR | $5,602,278Mid-sized | 84.37 |
| All India MissionEIN 33-0421940 | Religion | KS | $3,673,089Mid-sized | 76.66 |
| All Our KinEIN 06-1539280 | Human Services | CT | $3,609,613Mid-sized | 96.42 |
| All Stars ProjectEIN 13-3148295 | Human Services | NY | $9,902,638Mid-sized | 82.85 |
| Allentown Symphony AssociationEIN 23-6272140 | Arts, Culture, Humanities | PA | $3,619,870Mid-sized | 88.95 |
| Alley Cat AlliesEIN 52-1742079 | Animals | MD | $10,182,939Mid-sized | 93.98 |
| Alliance For ChildrenEIN 75-2363035 | Human Services | TX | $4,387,651Mid-sized | 94.10 |
| Alliance for Children's RightsEIN 95-4358213 | Human Services | CA | $5,808,946Mid-sized | 96.47 |
| Alliance for EducationEIN 91-1508191 | Education | WA | $4,429,976Mid-sized | 86.99 |
| Alliance for JusticeEIN 52-1009973 | Human and Civil Rights | DC | $5,029,169Mid-sized | 95.83 |
| Alliance For The Great LakesEIN 23-7104524 | Environment | IL | $3,549,306Mid-sized | 97.72 |
| Alliance of Resident Theatres/New YorkEIN 13-2768583 | Arts, Culture, Humanities | NY | $4,115,637Mid-sized | 91.58 |
| Alliance to Save EnergyEIN 52-1082991 | Environment | DC | $4,083,682Mid-sized | 70.28 |
| Allied Arts FoundationEIN 73-0804291 | Arts, Culture, Humanities | OK | $3,520,807Mid-sized | 84.42 |
| Alpha USAEIN 13-3962840 | Religion | IL | $8,024,235Mid-sized | 77.72 |
| Alpha-1 FoundationEIN 65-0585415 | Health | FL | $9,757,837Mid-sized | 97.13 |
| ALS Association Minnesota/North Dakota/South Dakota ChapterEIN 41-1756085 | Health | MN | $3,987,728Mid-sized | 88.65 |
| ALS Therapy Development InstituteEIN 04-3462719 | Health | MA | $12,533,202Mid-sized | 91.93 |
| Alternatives in ActionEIN 94-3210413 | Education | CA | $4,028,999Mid-sized | 87.25 |
| Alumni Association of Kansas State UniversityEIN 48-0495058 | Education | KS | $4,225,425Mid-sized | 83.30 |
| Alzheimer's Family CenterEIN 95-3463975 | Human Services | CA | $4,400,117Mid-sized | 93.36 |
| Alzheimer's Foundation of AmericaEIN 91-1792864 | Health | NY | $6,562,695Mid-sized | 95.73 |
| Amazon Conservation AssociationEIN 52-2211305 | Environment | DC | $5,038,940Mid-sized | 93.33 |
| Amazon Conservation TeamEIN 54-1915987 | Environment | VA | $6,486,299Mid-sized | 99.06 |
| America's Car MuseumEIN 91-1867848 | Arts, Culture, Humanities | WA | $4,221,742Mid-sized | 84.28 |
| America's KeswickEIN 21-0715335 | Religion | NJ | $4,262,848Mid-sized | 87.62 |
| America's Promise AllianceEIN 54-1848713 | Human Services | DC | $11,854,378Mid-sized | 84.10 |
| America's Second Harvest of the Big BendEIN 59-2610345 | Human Services | FL | $12,057,541Mid-sized | 89.98 |
| American Academy in BerlinEIN 52-1726273 | International | NY | $6,566,241Mid-sized | 84.15 |
| American Academy in RomeEIN 13-1623881 | International | NY | $12,511,030Mid-sized | 85.62 |
| American Academy of Arts and SciencesEIN 04-2103651 | Research and Public Policy | MA | $11,527,301Mid-sized | 91.00 |
| American Academy of Family Physicians FoundationEIN 44-6013671 | Health | KS | $4,372,723Mid-sized | 80.40 |
| American Bird ConservancyEIN 52-1501259 | Animals | VA | $12,830,927Mid-sized | 91.41 |
| American Brain Tumor AssociationEIN 23-7286648 | Health | IL | $5,638,221Mid-sized | 89.86 |
| American Civil Liberties Union Foundation of Northern CaliforniaEIN 94-0279770 | Human and Civil Rights | CA | $11,104,423Mid-sized | 87.28 |
| American Constitution Society for Law and PolicyEIN 52-2313694 | Research and Public Policy | DC | $5,891,120Mid-sized | 88.13 |
| American Council for an Energy-Efficient Economy EIN 94-2711707 | Research and Public Policy | DC | $9,400,072Mid-sized | 95.43 |
| American Dance FestivalEIN 06-0932294 | Arts, Culture, Humanities | NC | $3,568,666Mid-sized | 87.64 |
| American DocumentaryEIN 13-3447752 | Arts, Culture, Humanities | NY | $4,013,582Mid-sized | 89.53 |
| American Federation for Aging ResearchEIN 13-3045282 | Health | NY | $5,980,117Mid-sized | 92.92 |
| American Federation for Children Growth FundEIN 52-2111508 | Education | DC | $7,828,481Mid-sized | 83.70 |
| American Federation of Police and Concerned CitizensEIN 52-1127259 | Human Services | FL | $4,010,540Mid-sized | 70.02 |
| American Folk Art MuseumEIN 13-1985627 | Arts, Culture, Humanities | NY | $4,220,031Mid-sized | 85.39 |
| American Forest FoundationEIN 52-1235124 | Environment | DC | $13,062,939Mid-sized | 96.39 |
| American ForestsEIN 53-0196544 | Environment | DC | $5,495,270Mid-sized | 86.81 |
| American Foundation for the BlindEIN 13-5562161 | Human Services | VA | $12,764,530Mid-sized | 84.99 |
| American Friends of Kupat Ha'irEIN 20-1523797 | Human Services | NY | $6,536,406Mid-sized | 73.90 |
| American Friends of Leket IsraelEIN 20-8202424 | International | NJ | $5,856,154Mid-sized | 88.19 |
| American Friends of Meir PanimEIN 20-1582478 | Human Services | NY | $5,126,089Mid-sized | 92.41 |
| American Friends of Migdal OhrEIN 13-3389558 | Human Services | NY | $5,992,863Mid-sized | 94.44 |
| American Friends of NishmatEIN 04-3106173 | Education | NY | $3,613,549Mid-sized | 92.22 |