| American Friends of Shalva IsraelEIN 56-2676533 | Human Services | NY | $4,298,752Mid-sized | 87.30 |
| American Friends of the Israel Democracy InstituteEIN 13-3348313 | International | GA | $8,396,726Mid-sized | 73.82 |
| American Friends of the Israel Philharmonic OrchestraEIN 23-7183563 | Arts, Culture, Humanities | NY | $6,296,009Mid-sized | 86.19 |
| American Friends of the LouvreEIN 52-2376786 | Arts, Culture, Humanities | NY | $4,755,697Mid-sized | 92.02 |
| American Himalayan FoundationEIN 94-2951480 | International | CA | $5,218,592Mid-sized | 95.06 |
| American Immigration CouncilEIN 52-1549711 | Human and Civil Rights | DC | $5,483,109Mid-sized | 94.52 |
| American India FoundationEIN 13-4159765 | International | NY | $7,577,120Mid-sized | 91.04 |
| American Indian Science and Engineering SocietyEIN 73-1023474 | Human Services | NM | $4,132,365Mid-sized | 86.99 |
| American Institute for Economic ResearchEIN 04-2121305 | Research and Public Policy | MA | $4,008,116Mid-sized | 78.56 |
| American Legislative Exchange CouncilEIN 52-0140979 | Research and Public Policy | VA | $9,056,582Mid-sized | 80.87 |
| American Life LeagueEIN 52-1238301 | Human and Civil Rights | VA | $3,632,951Mid-sized | 70.76 |
| American Liver FoundationEIN 36-2883000 | Health | NY | $8,921,259Mid-sized | 87.43 |
| American Lung Association of the Midland StatesEIN 31-4379531 | Health | OH | $7,270,087Mid-sized | 87.46 |
| American Psychiatric Association FoundationEIN 13-0433740 | Health | DC | $5,462,166Mid-sized | 86.81 |
| American Quarter Horse FoundationEIN 51-0187823 | Education | TX | $3,881,056Mid-sized | 84.61 |
| American Relief Agency for the Horn of Africa (ARAHA)EIN 41-1989714 | International | MN | $6,168,900Mid-sized | 92.74 |
| American Repertory BalletEIN 21-0732575 | Arts, Culture, Humanities | NJ | $4,032,932Mid-sized | 80.78 |
| American Society of Transplant SurgeonsEIN 13-3048373 | Health | VA | $5,646,358Mid-sized | 83.97 |
| American Society of TransplantationEIN 42-1182936 | Health | NJ | $4,846,825Mid-sized | 90.68 |
| American Studies CenterEIN 51-0232804 | Research and Public Policy | VA | $7,739,721Mid-sized | 78.15 |
| American Swedish InstituteEIN 41-0711603 | Arts, Culture, Humanities | MN | $4,258,783Mid-sized | 88.46 |
| American Youth FoundationEIN 43-0652614 | Human Services | MO | $6,196,477Mid-sized | 92.39 |
| American-Scandinavian FoundationEIN 13-1623897 | International | NY | $4,819,474Mid-sized | 91.67 |
| Americans United for Separation of Church and StateEIN 53-0184647 | Human and Civil Rights | DC | $7,210,878Mid-sized | 81.63 |
| Americas SocietyEIN 13-2569185 | International | NY | $6,259,184Mid-sized | 87.88 |
| AMG InternationalEIN 13-1766596 | Religion | TN | $6,760,457Mid-sized | 89.17 |
| Amigos de las AméricasEIN 74-1547146 | International | TX | $4,223,247Mid-sized | 86.98 |
| Amigos for ChristEIN 58-2484257 | International | GA | $13,425,711Mid-sized | 100.00 |
| AMITEIN 13-5631502 | Education | NY | $10,330,407Mid-sized | 93.35 |
| Amoud FoundationEIN 75-2882187 | International | TX | $4,108,828Mid-sized | 86.79 |
| Amref Health AfricaEIN 13-1867411 | International | NY | $5,293,222Mid-sized | 85.36 |
| Anacostia Watershed SocietyEIN 52-1666511 | Environment | MD | $3,962,805Mid-sized | 90.58 |
| Anderson Ranch Arts CenterEIN 23-7267983 | Arts, Culture, Humanities | CO | $5,237,136Mid-sized | 84.61 |
| Andre Agassi Foundation for EducationEIN 34-1759295 | Education | NV | $8,074,205Mid-sized | 88.28 |
| Angel Flight WestEIN 95-3956297 | Health | CA | $8,131,490Mid-sized | 91.36 |
| Animal Defense League of TexasEIN 74-6002033 | Animals | TX | $5,059,654Mid-sized | 97.86 |
| Animal FriendsEIN 25-0951565 | Animals | PA | $6,341,173Mid-sized | 91.34 |
| Animal Humane New MexicoEIN 85-0207652 | Animals | NM | $6,189,256Mid-sized | 94.47 |
| Animal Legal Defense FundEIN 94-2681680 | Animals | CA | $12,487,558Mid-sized | 93.04 |
| Animal Rescue Fund of the HamptonsEIN 23-7400663 | Animals | NY | $4,545,405Mid-sized | 94.58 |
| Animal Rescue League of BostonEIN 04-2103714 | Animals | MA | $10,120,452Mid-sized | 86.86 |
| Animal Rescue League of IowaEIN 42-0680427 | Animals | IA | $5,904,398Mid-sized | 91.39 |
| Animal Welfare LeagueEIN 36-2235155 | Animals | IL | $6,855,668Mid-sized | 91.39 |
| Anne Arundel County Food BankEIN 52-1660473 | Human Services | MD | $3,890,270Mid-sized | 78.71 |
| Aplastic Anemia & MDS International FoundationEIN 52-1336903 | Health | MD | $6,448,619Mid-sized | 91.51 |
| Appalachia Service ProjectEIN 62-0989383 | Community Development | TN | $11,166,665Mid-sized | 92.92 |
| Appalachian Trail ConservancyEIN 52-6046689 | Environment | WV | $9,331,050Mid-sized | 94.19 |
| Appell Center for the Performing ArtsEIN 23-2053382 | Arts, Culture, Humanities | PA | $4,336,351Mid-sized | 86.05 |
| Arby's FoundationEIN 58-1692997 | Human Services | GA | $8,124,464Mid-sized | 94.58 |
| Archaeological ConservancyEIN 95-3403273 | Arts, Culture, Humanities | NM | $3,693,315Mid-sized | 96.66 |
| Arizona Animal Welfare League & SPCAEIN 23-7149453 | Animals | AZ | $4,398,395Mid-sized | 93.87 |
| Arizona OperaEIN 23-7169261 | Arts, Culture, Humanities | AZ | $6,211,715Mid-sized | 85.69 |
| Arizona Private Education Scholarship FundEIN 86-0958161 | Education | AZ | $6,349,350Mid-sized | 94.74 |
| Arizona Science CenterEIN 86-0390558 | Arts, Culture, Humanities | AZ | $9,868,682Mid-sized | 81.77 |
| Arizona-Sonora Desert MuseumEIN 86-0111675 | Arts, Culture, Humanities | AZ | $10,274,415Mid-sized | 89.88 |
| Arkansas Baptist Children's Homes and Family MinistriesEIN 71-0296619 | Human Services | AR | $4,388,581Mid-sized | 86.51 |
| Arkansas Repertory Theatre CompanyEIN 71-0480336 | Arts, Culture, Humanities | AR | $4,642,033Mid-sized | 82.15 |
| Arlington Food Assistance CenterEIN 54-1473207 | Human Services | VA | $5,583,702Mid-sized | 96.40 |
| Arlington Free ClinicEIN 54-1671883 | Health | VA | $4,036,752Mid-sized | 90.45 |
| Arlington Street People's Assistance NetworkEIN 54-1615993 | Human Services | VA | $4,004,806Mid-sized | 90.58 |