| Cape Cod Commercial Fishermen's AllianceEIN 04-3138784 | Environment | MA | $2,000,667Small | 88.88 |
| Cape Eleuthera FoundationEIN 31-1591503 | Education | MA | $2,795,055Small | 89.62 |
| Catholic Schools FoundationEIN 22-2485502 | Education | MA | $11,109,378Mid-sized | 96.08 |
| CatholicTVEIN 04-2395520 | Religion | MA | $9,283,767Mid-sized | 80.75 |
| Celebrity Series of BostonEIN 22-2958508 | Arts, Culture, Humanities | MA | $7,898,914Mid-sized | 91.75 |
| Cell Phones For SoldiersEIN 20-1343425 | Human Services | MA | $559,483Small | 66.97 |
| Center for Coastal StudiesEIN 04-2609788 | Environment | MA | $3,586,500Mid-sized | 94.03 |
| Center for Collaborative EducationEIN 04-3241676 | Education | MA | $4,694,075Mid-sized | 84.78 |
| Center for Public Interest ResearchEIN 04-2863170 | Research and Public Policy | MA | $3,214,538Small | 71.66 |
| Center for Women & EnterpriseEIN 04-3256236 | Community Development | MA | $2,797,407Small | 84.58 |
| CeresEIN 22-3053747 | Environment | MA | $14,937,631Large | 96.52 |
| Charles River Watershed AssociationEIN 04-6136989 | Environment | MA | $1,159,643Small | 76.43 |
| Child Rights And You AmericaEIN 02-0659244 | International | MA | $1,296,605Small | 71.82 |
| Citizen SchoolsEIN 04-3259160 | Education | MA | $20,565,491Large | 85.00 |
| City YearEIN 22-2882549 | Human Services | MA | $148,415,766Large | 92.67 |
| Clarke Schools for Hearing and SpeechEIN 04-2104008 | Education | MA | $11,678,628Mid-sized | 82.72 |
| Clean Air Task ForceEIN 04-3512550 | Research and Public Policy | MA | $5,368,687Mid-sized | 93.52 |
| Combined Jewish PhilanthropiesEIN 04-2103559 | Community Development | MA | $166,682,869Large | 94.56 |
| Committee for Accuracy in Middle East Reporting in AmericaEIN 52-1332702 | International | MA | $4,796,135Mid-sized | 93.69 |
| CommonwealthEIN 04-3540147 | Community Development | MA | $1,993,340Small | 91.42 |
| Community Catalyst EIN 04-3355127 | Human and Civil Rights | MA | $12,149,963Mid-sized | 91.21 |
| Community Foundation of Western MassachusettsEIN 22-3089640 | Community Development | MA | $10,280,261Mid-sized | 86.50 |
| Community Involved in Sustaining AgricultureEIN 04-3416862 | Community Development | MA | $1,375,996Small | 91.17 |
| Community ServingsEIN 22-3154028 | Human Services | MA | $6,196,962Mid-sized | 89.01 |
| Compassionate Care ALSEIN 04-3567819 | Health | MA | $1,330,284Small | 93.12 |
| Concord MuseumEIN 04-2104035 | Arts, Culture, Humanities | MA | $2,742,553Small | 81.67 |
| Conservation Law FoundationEIN 04-6149986 | Environment | MA | $9,439,409Mid-sized | 91.21 |
| Corporate AccountabilityEIN 41-1322686 | Human and Civil Rights | MA | $6,385,613Mid-sized | 93.30 |
| Council of Social ConcernEIN 04-2494773 | Human Services | MA | $2,065,231Small | 79.59 |
| Cradles to CrayonsEIN 04-3584367 | Human Services | MA | $15,682,610Large | 96.46 |
| Cultural SurvivalEIN 23-7182593 | Human and Civil Rights | MA | $2,010,575Small | 88.27 |
| Cure Alzheimer's FundEIN 52-2396428 | Health | MA | $18,999,554Large | 98.23 |
| Dakin Humane SocietyEIN 20-5318898 | Animals | MA | $3,483,198Small | 87.67 |
| Dana-Farber Cancer InstituteEIN 04-2263040 | Health | MA | $1,528,239,259Large | 92.74 |
| Danforth ArtEIN 04-2526917 | Arts, Culture, Humanities | MA | $1,216,820Small | 75.73 |
| DeCordova Sculpture Park and MuseumEIN 04-2067315 | Arts, Culture, Humanities | MA | $4,862,222Mid-sized | 79.43 |
| Discovery MuseumEIN 04-2741645 | Arts, Culture, Humanities | MA | $1,841,437Small | 87.63 |
| Doug Flutie Jr. Foundation For AutismEIN 04-3543134 | Health | MA | $1,281,666Small | 87.31 |
| Earthwatch InstituteEIN 23-7168440 | Research and Public Policy | MA | $7,458,378Mid-sized | 86.99 |
| East End HouseEIN 04-2104163 | Human Services | MA | $2,610,655Small | 80.06 |
| EcoLogic Development FundEIN 25-1704582 | Environment | MA | $1,487,137Small | 81.51 |
| EcoTariumEIN 04-2105868 | Arts, Culture, Humanities | MA | $4,965,747Mid-sized | 88.48 |
| EdVestorsEIN 76-0794873 | Education | MA | $3,232,210Small | 84.68 |
| El Hogar MinistriesEIN 04-3580644 | International | MA | $1,498,436Small | 91.26 |
| Emerald Necklace ConservancyEIN 04-3414988 | Environment | MA | $1,687,443Small | 83.01 |
| Epiphany SchoolEIN 04-3391788 | Education | MA | $4,014,326Mid-sized | 83.21 |
| Eric Carle Museum of Picture Book ArtEIN 04-3542086 | Arts, Culture, Humanities | MA | $3,180,878Small | 84.43 |
| Facing History and OurselvesEIN 04-2761636 | Education | MA | $22,964,673Large | 89.69 |
| Falmouth Service CenterEIN 22-2509781 | Human Services | MA | $2,311,509Small | 96.46 |
| Farm AidEIN 36-3383233 | Human Services | MA | $2,269,513Small | 87.93 |
| Foundation for MetroWestEIN 04-3266789 | Community Development | MA | $2,732,867Small | 85.20 |
| FRAXA Research FoundationEIN 04-3222167 | Health | MA | $1,497,101Small | 97.17 |
| Free PressEIN 41-2106721 | Human and Civil Rights | MA | $3,278,337Small | 96.04 |
| Free Software FoundationEIN 04-2888848 | Human and Civil Rights | MA | $1,233,394Small | 96.66 |
| Friends of Mount Auburn CemeteryEIN 22-3084639 | Arts, Culture, Humanities | MA | $1,805,666Small | 76.39 |
| Friends of the Arava InstituteEIN 11-3485736 | Environment | MA | $1,440,708Small | 82.81 |
| Friendship Home, MassachusettsEIN 04-8295500 | Human Services | MA | $2,234,394Small | 81.87 |
| From the TopEIN 04-3583756 | Arts, Culture, Humanities | MA | $3,335,227Small | 86.68 |
| Fruitlands MuseumEIN 04-2125003 | Arts, Culture, Humanities | MA | $1,717,051Small | 74.51 |
| FSH SocietyEIN 52-1762747 | Health | MA | $2,423,238Small | 95.03 |