| Special Olympics OregonEIN 93-0752969 | Human Services | OR | $4,858,280Mid-sized | 73.03 |
| Special Olympics South CarolinaEIN 57-0680248 | Human Services | SC | $2,816,864Small | 91.89 |
| Special Olympics South DakotaEIN 46-0359776 | Human Services | SD | $1,508,882Small | 92.62 |
| Special Olympics Southern CaliforniaEIN 95-4538450 | Human Services | CA | $11,029,255Mid-sized | 97.23 |
| Special Olympics TennesseeEIN 23-7348136 | Human Services | TN | $1,738,490Small | 85.72 |
| Special Olympics TexasEIN 74-1998367 | Human Services | TX | $9,080,131Mid-sized | 86.84 |
| Special Olympics VirginiaEIN 54-1013637 | Human Services | VA | $4,833,080Mid-sized | 89.91 |
| Special Olympics WashingtonEIN 91-0962383 | Human Services | WA | $4,115,372Mid-sized | 85.40 |
| Special Olympics WisconsinEIN 39-1176591 | Human Services | WI | $4,554,211Mid-sized | 82.06 |
| Special Operations Warrior FoundationEIN 52-1183585 | Education | FL | $11,730,490Mid-sized | 94.47 |
| Speedway Children's CharitiesEIN 56-1331429 | Education | NC | $3,925,136Mid-sized | 86.80 |
| Spence-Chapin Services to Families and ChildrenEIN 13-1834590 | Human Services | NY | $7,266,046Mid-sized | 81.35 |
| Spina Bifida AssociationEIN 58-1342181 | Health | VA | $1,821,008Small | 82.11 |
| Spirit of AmericaEIN 20-1687786 | International | VA | $3,626,101Mid-sized | 96.83 |
| Splash InternationalEIN 56-2600599 | International | WA | $3,266,231Small | 94.18 |
| Spokane County United WayEIN 91-0606058 | Community Development | WA | $4,118,437Mid-sized | 86.72 |
| Spokane Valley PartnersEIN 91-1478830 | Human Services | WA | $3,099,717Small | 82.63 |
| Spoleto Festival USAEIN 57-0660848 | Arts, Culture, Humanities | SC | $8,737,036Mid-sized | 82.85 |
| Spondylitis Association of AmericaEIN 95-3890767 | Health | CA | $1,301,054Small | 91.90 |
| Sponsors for Educational Opportunity (SEO)EIN 13-2578670 | Education | NY | $17,839,508Large | 99.93 |
| Sports Outreach InstituteEIN 54-1479310 | Religion | VA | $1,923,423Small | 85.93 |
| Sports World, Inc.EIN 23-7073822 | Religion | IN | $1,106,989Small | 75.82 |
| Sportsmen's Alliance FoundationEIN 31-0941103 | Animals | OH | $1,443,394Small | 89.30 |
| Sportsmen's Tennis & Enrichment CenterEIN 23-7037183 | Human Services | MA | $1,815,033Small | 83.64 |
| Spread the Word NevadaEIN 22-3829041 | Education | NV | $3,504,067Mid-sized | 98.23 |
| Springfield Library and Museums AssociationEIN 04-6002239 | Arts, Culture, Humanities | MA | $7,616,989Mid-sized | 87.57 |
| Springfield Rescue MissionEIN 52-1047790 | Human Services | MA | $5,894,186Mid-sized | 80.93 |
| Springfield Victory MissionEIN 43-1345089 | Human Services | MO | $2,352,783Small | 79.57 |
| Springs Rescue MissionEIN 84-1340824 | Human Services | CO | $11,053,485Mid-sized | 87.91 |
| SPUREIN 94-1498232 | Research and Public Policy | CA | $6,462,777Mid-sized | 88.07 |
| SquashBustersEIN 04-3330698 | Education | MA | $2,154,696Small | 91.21 |
| St. Ann's Center for Children, Youth and FamiliesEIN 53-0204626 | Human Services | MD | $4,519,774Mid-sized | 90.31 |
| St. Anne'sEIN 95-1691306 | Human Services | CA | $25,417,077Large | 93.91 |
| St. Baldrick's FoundationEIN 20-1173824 | Health | CA | $41,680,500Large | 77.72 |
| St. Boniface Haiti FoundationEIN 04-3067595 | International | MA | $22,333,400Large | 95.87 |
| St. Francis CenterEIN 95-4479271 | Human Services | CA | $3,444,965Small | 87.34 |
| St. Francis HouseEIN 22-2519129 | Human Services | MA | $8,991,131Mid-sized | 83.47 |
| St. Gerard CampusEIN 59-2483955 | Human Services | FL | $756,996Small | 74.01 |
| St. Hubert's Animal Welfare CenterEIN 22-1627726 | Animals | NJ | $5,921,842Mid-sized | 98.16 |
| St. John CenterEIN 61-1135907 | Human Services | KY | $1,261,698Small | 88.93 |
| St. John's Bread & LifeEIN 11-3174514 | Human Services | NY | $4,064,642Mid-sized | 89.71 |
| St. Joseph CenterEIN 95-3874381 | Human Services | CA | $15,753,740Large | 91.58 |
| St. Joseph Food ProgramEIN 39-1822486 | Human Services | WI | $6,098,206Mid-sized | 66.71 |
| St. Louis Area FoodbankEIN 43-1253102 | Human Services | MO | $81,514,749Large | 98.86 |
| St. Louis Public Library FoundationEIN 43-1541947 | Arts, Culture, Humanities | MO | $744,456Small | 79.60 |
| St. Mary's CenterEIN 68-0172229 | Human Services | CA | $3,039,558Small | 96.66 |
| St. Mary's Dining RoomEIN 94-2687280 | Human Services | CA | $2,522,317Small | 87.86 |
| St. Mary's Food Bank AllianceEIN 23-7353532 | Human Services | AZ | $160,093,972Large | 93.07 |
| St. Mary's SewaneeEIN 62-1359755 | Religion | TN | $915,612Small | 74.38 |
| St. Matthew's HouseEIN 65-1110501 | Human Services | FL | $7,624,221Mid-sized | 92.14 |
| St. Patrick CenterEIN 43-1263499 | Human Services | MO | $16,391,436Large | 85.08 |
| St. Petersburg Free ClinicEIN 23-7208280 | Health | FL | $12,323,655Mid-sized | 97.17 |
| St. Rita School for the DeafEIN 31-0537509 | Education | OH | $6,147,225Mid-sized | 87.66 |
| St. Vincent de Paul DetroitEIN 38-1359592 | Human Services | MI | $15,821,834Large | 89.01 |
| St. Vincent de Paul of BaltimoreEIN 52-0597056 | Human Services | MD | $20,808,081Large | 94.18 |
| St. Vincent de Paul of Seattle|King CountyEIN 91-0583891 | Human Services | WA | $10,749,665Mid-sized | 85.01 |
| St. Vincent de Paul Society of Marin CountyEIN 94-1207701 | Human Services | CA | $4,107,059Mid-sized | 96.42 |
| St. Vincent de Paul VillageEIN 33-0492302 | Human Services | CA | $31,913,973Large | 81.26 |
| St. Vincent Meals on WheelsEIN 95-3696693 | Human Services | CA | $8,085,613Mid-sized | 86.11 |
| Stamford Center for the ArtsEIN 06-1048684 | Arts, Culture, Humanities | CT | $3,601,344Mid-sized | 86.08 |