| La Casa de las MadresEIN 94-2330864 | Human Services | CA | $2,590,639Small | 86.81 |
| La Comunidad Hispana (LCH)EIN 23-2041915 | Health | PA | $5,092,573Mid-sized | 99.95 |
| La Jolla Music SocietyEIN 23-7148171 | Arts, Culture, Humanities | CA | $4,368,421Mid-sized | 85.59 |
| La Jolla PlayhouseEIN 95-1941117 | Arts, Culture, Humanities | CA | $19,706,336Large | 87.34 |
| La Leche League InternationalEIN 36-2514518 | Human Services | NC | $938,688Small | 72.36 |
| LA OperaEIN 95-2096402 | Arts, Culture, Humanities | CA | $42,265,305Large | 87.42 |
| LA Promise FundEIN 20-4562686 | Education | CA | $5,769,247Mid-sized | 93.65 |
| Lackey ClinicEIN 54-1850915 | Health | VA | $9,322,438Mid-sized | 91.31 |
| Laguna Art MuseumEIN 33-0717157 | Arts, Culture, Humanities | CA | $2,339,192Small | 73.10 |
| Lake Area United WayEIN 23-7170019 | Community Development | IN | $3,382,305Small | 75.74 |
| Lake Erie Nature & Science CenterEIN 34-0845030 | Arts, Culture, Humanities | OH | $1,414,666Small | 92.23 |
| Lakeland Public TelevisionEIN 41-1265701 | Arts, Culture, Humanities | MN | $2,788,423Small | 87.20 |
| Lakeland Volunteers in MedicineEIN 52-2351630 | Health | FL | $1,812,580Small | 81.96 |
| Lakeshore Habitat for HumanityEIN 38-2893355 | Community Development | MI | $2,460,211Small | 88.18 |
| Lakeview Cemetery FoundationEIN 34-1429875 | Arts, Culture, Humanities | OH | $1,539,223Small | 81.69 |
| Lakeview PantryEIN 36-2734184 | Human Services | IL | $5,200,543Mid-sized | 87.11 |
| Lamb & Lion MinistriesEIN 75-1717049 | Religion | TX | $3,036,788Small | 95.95 |
| Lambda LegalEIN 23-7395681 | Human and Civil Rights | NY | $3,373,779Small | 81.46 |
| LancasterHistory.orgEIN 23-1365154 | Arts, Culture, Humanities | PA | $2,255,715Small | 76.17 |
| Land Stewardship ProjectEIN 41-1466054 | Environment | MN | $2,524,386Small | 87.93 |
| LAND studioEIN 34-1212421 | Environment | OH | $3,900,114Mid-sized | 86.27 |
| Land Trust AllianceEIN 04-2751357 | Environment | DC | $15,111,306Large | 90.85 |
| LandesaEIN 91-1158970 | International | WA | $12,473,980Mid-sized | 94.59 |
| Landmark Legal FoundationEIN 51-0203802 | Human and Civil Rights | VA | $1,800,533Small | 69.76 |
| Landmark on Main StreetEIN 11-2444833 | Arts, Culture, Humanities | NY | $1,510,616Small | 91.18 |
| Lange FoundationEIN 95-4407687 | Animals | CA | $1,705,600Small | 96.22 |
| Langham PartnershipEIN 23-7417198 | Religion | AZ | $4,124,812Mid-sized | 81.10 |
| Lankenau Institute for Medical ResearchEIN 23-2175659 | Health | PA | $16,847,810Large | 81.99 |
| Lantern HouseEIN 87-0368808 | Human Services | UT | $2,766,907Small | 76.66 |
| Larkin Street Youth ServicesEIN 94-2917999 | Human Services | CA | $18,597,674Large | 90.64 |
| Las Vegas Rescue MissionEIN 23-7222330 | Human Services | NV | $5,012,654Mid-sized | 82.74 |
| Last Chance for AnimalsEIN 95-4013155 | Animals | CA | $2,442,653Small | 98.23 |
| Latin American AssociationEIN 58-1237316 | Human Services | GA | $3,759,451Mid-sized | 91.05 |
| Latino Health AccessEIN 33-0562943 | Human Services | CA | $2,557,543Small | 85.02 |
| Latino Policy ForumEIN 36-3676873 | Human and Civil Rights | IL | $1,400,304Small | 82.88 |
| LatinoJustice PRLDEFEIN 13-2722664 | Human and Civil Rights | NY | $2,720,183Small | 85.76 |
| Laumeier Sculpture ParkEIN 43-1131429 | Arts, Culture, Humanities | MO | $1,879,075Small | 73.48 |
| Laura's HouseEIN 33-0621826 | Human Services | CA | $3,677,412Mid-sized | 91.77 |
| Lauritzen GardensEIN 47-0659701 | Environment | NE | $6,507,988Mid-sized | 84.42 |
| Lausanne Committee for World EvangelizationEIN 33-0901290 | Religion | FL | $1,298,608Small | 73.46 |
| Law Enforcement Education ProgramEIN 38-3385175 | Human Services | MI | $1,443,890Small | 24.35 |
| Law Enforcement Legal Defense FundEIN 52-1095066 | Human and Civil Rights | VA | $1,632,586Small | 87.54 |
| Lawrence Family Jewish Community Center, Jacobs Family CampusEIN 95-1985444 | Human Services | CA | $12,171,345Mid-sized | 90.46 |
| Lawyers Alliance for New YorkEIN 13-2666432 | Human and Civil Rights | NY | $3,003,462Small | 87.33 |
| Lawyers' Committee for Civil Rights Under LawEIN 52-0799246 | Human and Civil Rights | DC | $7,241,908Mid-sized | 87.31 |
| Lazarus HouseEIN 04-2755382 | Human Services | MA | $8,732,769Mid-sized | 88.94 |
| Leader Dogs for the BlindEIN 38-1366931 | Human Services | MI | $14,964,355Large | 85.08 |
| Leadership Conference Education FundEIN 23-7026895 | Human and Civil Rights | DC | $11,075,584Mid-sized | 90.72 |
| Leadership MemphisEIN 62-1043517 | Community Development | TN | $1,768,006Small | 92.02 |
| Leadership Resources InternationalEIN 36-2972097 | Religion | IL | $3,155,098Small | 81.87 |
| Leadership RoundtableEIN 54-2174467 | Religion | DC | $2,362,890Small | 80.46 |
| LEADership, Education and DevelopmentEIN 23-2139831 | Education | GA | $695,511Small | 52.72 |
| Leading The Way with Dr. Michael YoussefEIN 58-1816773 | Religion | GA | $17,173,030Large | 97.10 |
| League for Animal WelfareEIN 31-0818511 | Animals | OH | $1,511,108Small | 93.36 |
| League of American BicyclistsEIN 36-6206225 | Research and Public Policy | DC | $1,587,429Small | 81.45 |
| League of American OrchestrasEIN 23-7300636 | Arts, Culture, Humanities | NY | $7,061,267Mid-sized | 90.36 |
| League of Conservation Voters Education FundEIN 52-1379661 | Environment | DC | $18,493,698Large | 92.02 |
| League of Education Voters FoundationEIN 91-2141507 | Education | WA | $3,258,126Small | 87.56 |
| League of Women Voters Education FundEIN 53-0239013 | Human and Civil Rights | DC | $2,592,235Small | 74.42 |
| League to Save Lake TahoeEIN 94-6128680 | Environment | CA | $2,194,842Small | 85.65 |