| Saban Community ClinicEIN 95-2539105 | Health | CA | $22,618,402Large | 93.91 |
| Sabathani Community CenterEIN 41-0984859 | Human Services | MN | $2,184,671Small | 86.37 |
| Sabin Vaccine InstituteEIN 06-1389829 | Health | DC | $10,566,671Mid-sized | 89.39 |
| Sacramento Food Bank & Family ServicesEIN 94-3315566 | Human Services | CA | $42,378,801Large | 88.81 |
| Sacramento Habitat for HumanityEIN 68-0085804 | Community Development | CA | $3,599,686Mid-sized | 85.85 |
| Sacramento Loaves & FishesEIN 68-0189897 | Human Services | CA | $6,533,895Mid-sized | 96.86 |
| Sacramento SPCAEIN 94-1312343 | Animals | CA | $6,899,840Mid-sized | 87.77 |
| Sacramento ZooEIN 94-2861667 | Animals | CA | $7,227,802Mid-sized | 91.17 |
| Sacred Heart CenterEIN 46-0417196 | Human Services | SD | $4,556,342Mid-sized | 68.70 |
| Sacred Heart Community ServiceEIN 23-7179787 | Human Services | CA | $22,848,309Large | 93.77 |
| Sacred Heart Nativity SchoolEIN 95-2206754 | Education | CA | $2,188,299Small | 84.59 |
| Saddle Up!EIN 58-1930303 | Human Services | TN | $1,055,317Small | 87.81 |
| Safari Club International Foundation EIN 86-0292099 | Animals | AZ | $5,600,170Mid-sized | 86.68 |
| Safe & SoundEIN 94-2455072 | Human Services | CA | $5,939,180Mid-sized | 94.17 |
| Safe ConnectionsEIN 43-1077667 | Human Services | MO | $2,357,049Small | 90.14 |
| Safe Haven Family ShelterEIN 62-1807653 | Human Services | TN | $2,082,147Small | 94.94 |
| Safe Kids WorldwideEIN 52-1627574 | Research and Public Policy | DC | $11,486,479Mid-sized | 89.78 |
| Safe Nest: Temporary Assistance for Domestic CrisisEIN 94-2411883 | Human Services | NV | $5,347,813Mid-sized | 76.21 |
| Safe PassageEIN 01-0532835 | International | ME | $2,200,573Small | 84.19 |
| Safe Place of the Permian BasinEIN 75-1657264 | Human Services | TX | $1,809,322Small | 85.44 |
| Safe Water NetworkEIN 51-0570455 | International | NY | $4,401,103Mid-sized | 93.60 |
| SAFEchildEIN 56-1817816 | Human Services | NC | $1,394,963Small | 92.22 |
| SafeHaven of Tarrant CountyEIN 75-1670281 | Human Services | TX | $7,907,012Mid-sized | 92.70 |
| SAFEHOMEEIN 48-0917798 | Human Services | KS | $3,636,486Mid-sized | 96.19 |
| SafeHouse CenterEIN 38-2121751 | Human Services | MI | $2,244,935Small | 93.08 |
| SafeHouse OutreachEIN 58-2130936 | Human Services | GA | $966,006Small | 78.67 |
| SAG-AFTRA FoundationEIN 95-3967876 | Arts, Culture, Humanities | CA | $7,330,396Mid-sized | 91.90 |
| SAGEEIN 13-2947657 | Human and Civil Rights | NY | $10,131,295Mid-sized | 89.23 |
| SAGE EldercareEIN 22-1657929 | Human Services | NJ | $3,605,635Mid-sized | 86.41 |
| Saginaw Art MuseumEIN 38-1280546 | Arts, Culture, Humanities | MI | $811,425Small | 82.71 |
| Saint Louis Symphony OrchestraEIN 43-0666769 | Arts, Culture, Humanities | MO | $30,010,463Large | 86.41 |
| Saint Louis Zoo AssociationEIN 43-1727309 | Animals | MO | $16,950,536Large | 91.13 |
| Saint Paul Chamber OrchestraEIN 41-0829498 | Arts, Culture, Humanities | MN | $10,773,391Mid-sized | 88.65 |
| Salina Area United WayEIN 48-0573808 | Community Development | KS | $855,591Small | 82.71 |
| Salina Rescue MissionEIN 48-0944358 | Human Services | KS | $1,309,100Small | 93.77 |
| Salk Institute for Biological StudiesEIN 95-2160097 | Health | CA | $119,364,264Large | 91.35 |
| Salvador Dalí MuseumEIN 59-2015192 | Arts, Culture, Humanities | FL | $10,091,648Mid-sized | 86.60 |
| Salvadoran American Humanitarian FoundationEIN 59-2339140 | International | FL | $25,123,269Large | 94.69 |
| Salzburg Global SeminarEIN 04-2200147 | Research and Public Policy | DC | $8,340,061Mid-sized | 78.57 |
| Samaritan Center for Young Boys & FamiliesEIN 59-1373247 | Human Services | FL | $503,874Small | 73.91 |
| Samaritan HouseEIN 23-7416272 | Human Services | CA | $10,205,305Mid-sized | 94.93 |
| Samaritan InnsEIN 52-1474935 | Human Services | DC | $3,384,447Small | 97.66 |
| Samaritan MinistriesEIN 56-1490019 | Human Services | NC | $1,372,704Small | 87.50 |
| Samaritan Ministry of Greater WashingtonEIN 52-1434143 | Human Services | DC | $1,171,383Small | 92.80 |
| Samaritan's FeetEIN 14-1880905 | International | NC | $7,532,515Mid-sized | 92.38 |
| Samaritan's PurseEIN 58-1437002 | International | NC | $595,259,892Large | 95.85 |
| SamaritansEIN 04-2643466 | Health | MA | $1,950,989Small | 82.85 |
| SAMMinistriesEIN 74-2285793 | Human Services | TX | $11,377,425Mid-sized | 86.35 |
| Samuel Waxman Cancer Research FoundationEIN 13-3020943 | Health | NY | $2,301,162Small | 78.41 |
| San Angelo Area FoundationEIN 73-1634145 | Community Development | TX | $9,025,193Mid-sized | 91.42 |
| San Antonio Botanical Garden SocietyEIN 74-2178792 | Environment | TX | $2,825,220Small | 88.42 |
| San Antonio Food BankEIN 74-2122979 | Human Services | TX | $129,142,157Large | 95.96 |
| San Antonio Humane SocietyEIN 74-6024105 | Animals | TX | $4,354,685Mid-sized | 95.34 |
| San Antonio Museum of ArtEIN 74-2689943 | Arts, Culture, Humanities | TX | $9,370,712Mid-sized | 82.54 |
| San Diego Botanic GardenEIN 95-6120581 | Environment | CA | $2,978,807Small | 84.42 |
| San Diego Center for the BlindEIN 95-3076944 | Health | CA | $1,712,478Small | 94.05 |
| San Diego Children's Discovery MuseumEIN 33-0912735 | Arts, Culture, Humanities | CA | $1,516,896Small | 91.02 |
| San Diego CoastkeeperEIN 33-0647946 | Environment | CA | $668,734Small | 78.81 |
| San Diego Habitat for HumanityEIN 33-0259190 | Community Development | CA | $10,957,226Mid-sized | 92.92 |
| San Diego History CenterEIN 95-1728991 | Arts, Culture, Humanities | CA | $2,750,444Small | 80.20 |