| Save Our YouthEIN 84-1295393 | Human Services | CO | $1,378,599Small | 72.08 |
| Save the ChildrenEIN 06-0726487 | International | CT | $719,647,258Large | 85.21 |
| Save the FamilyEIN 86-0665712 | Human Services | AZ | $5,414,265Mid-sized | 81.68 |
| Save the Manatee ClubEIN 59-3131709 | Animals | FL | $1,168,356Small | 90.23 |
| SAVE, A Friend to Homeless AnimalsEIN 22-6082741 | Animals | NJ | $1,313,195Small | 90.29 |
| Save-A-Pet Adoption CenterEIN 23-7304570 | Animals | IL | $1,746,870Small | 91.33 |
| SBH Community Service NetworkEIN 23-7406410 | Human Services | NY | $9,752,470Mid-sized | 96.54 |
| SBPEIN 26-2189665 | Human Services | LA | $15,115,618Large | 95.12 |
| Schlitz Audubon Nature CenterEIN 39-1231819 | Environment | WI | $2,897,570Small | 90.69 |
| Scholarship AmericaEIN 04-2296967 | Education | MN | $187,899,785Large | 86.07 |
| Scholarship Foundation of Santa BarbaraEIN 23-7087774 | Education | CA | $10,071,712Mid-sized | 91.88 |
| Scholarship Foundation of St. LouisEIN 43-6031234 | Education | MO | $6,200,105Mid-sized | 87.18 |
| Scholastic Art & Writing AwardsEIN 13-3780998 | Education | NY | $3,826,838Mid-sized | 81.28 |
| School for Advanced ResearchEIN 85-0125045 | Education | NM | $3,536,710Mid-sized | 88.22 |
| School on WheelsEIN 95-4422640 | Education | CA | $2,114,477Small | 95.47 |
| Schoolseed FoundationEIN 26-4477567 | Education | TN | $2,998,033Small | 88.14 |
| Sci-PortEIN 72-1136273 | Arts, Culture, Humanities | LA | $2,808,564Small | 65.56 |
| Science Center of IowaEIN 42-6097912 | Arts, Culture, Humanities | IA | $7,395,900Mid-sized | 88.53 |
| Science CentralEIN 31-1032583 | Arts, Culture, Humanities | IN | $1,724,835Small | 88.58 |
| Science Friday InitiativeEIN 13-4252173 | Arts, Culture, Humanities | NY | $2,963,802Small | 92.22 |
| Science Museum of MinnesotaEIN 41-0706172 | Arts, Culture, Humanities | MN | $39,667,153Large | 89.37 |
| Science Museum of Western VirginiaEIN 54-1023953 | Arts, Culture, Humanities | VA | $871,912Small | 88.97 |
| Science Museum OklahomaEIN 73-0682415 | Arts, Culture, Humanities | OK | $10,733,779Mid-sized | 96.87 |
| Scleroderma FoundationEIN 52-1375827 | Health | MA | $5,211,320Mid-sized | 96.52 |
| Scleroderma Research FoundationEIN 68-0087234 | Health | CA | $2,527,636Small | 97.17 |
| SCORE InternationalEIN 58-1605736 | Religion | TN | $8,470,138Mid-sized | 82.33 |
| Scott County Family YEIN 42-0703278 | Human Services | IA | $10,300,667Mid-sized | 93.54 |
| Scottsdale Cultural CouncilEIN 86-0593786 | Arts, Culture, Humanities | AZ | $11,500,947Mid-sized | 82.14 |
| Scottsdale League for the ArtsEIN 94-2562752 | Arts, Culture, Humanities | AZ | $418,735Small | 60.53 |
| Scripture Memory Mountain MissionEIN 61-6034476 | Religion | KY | $1,260,347Small | 64.88 |
| Scripture Union/USAEIN 25-1228715 | Religion | PA | $1,673,692Small | 83.74 |
| Sea Education AssociationEIN 04-2702102 | Education | MA | $8,416,413Mid-sized | 83.40 |
| Sea Turtle ConservancyEIN 59-6151069 | Animals | FL | $3,339,353Small | 96.46 |
| SeaGate Food BankEIN 51-0252948 | Human Services | OH | $6,481,656Mid-sized | 88.83 |
| Search and CareEIN 23-7444790 | Human Services | NY | $1,381,511Small | 94.70 |
| SeaShareEIN 91-1641242 | Human Services | WA | $3,409,125Small | 87.06 |
| Seattle Aquarium EIN 91-1189249 | Animals | WA | $16,757,036Large | 84.83 |
| Seattle Art MuseumEIN 91-0640788 | Arts, Culture, Humanities | WA | $38,076,158Large | 87.24 |
| Seattle Arts and LecturesEIN 91-1384964 | Arts, Culture, Humanities | WA | $1,666,625Small | 90.52 |
| Seattle Audubon SocietyEIN 91-6009716 | Environment | WA | $1,068,105Small | 86.75 |
| Seattle Children's TheatreEIN 51-0172421 | Arts, Culture, Humanities | WA | $6,887,908Mid-sized | 86.49 |
| Seattle FoundationEIN 91-6013536 | Community Development | WA | $110,286,703Large | 94.51 |
| Seattle HumaneEIN 91-0282060 | Animals | WA | $6,703,024Mid-sized | 89.34 |
| Seattle OperaEIN 91-0760426 | Arts, Culture, Humanities | WA | $23,067,246Large | 82.88 |
| Seattle Parks FoundationEIN 91-1998597 | Environment | WA | $2,525,864Small | 97.13 |
| Seattle Repertory TheatreEIN 91-0756535 | Arts, Culture, Humanities | WA | $15,089,316Large | 84.81 |
| Second Amendment FoundationEIN 91-6184167 | Human and Civil Rights | WA | $4,129,021Mid-sized | 74.92 |
| Second ChanceEIN 52-2276640 | Education | MD | $8,034,442Mid-sized | 85.43 |
| Second Harvest Community Food BankEIN 43-1268319 | Human Services | MO | $10,909,604Mid-sized | 93.83 |
| Second Harvest Food Bank of Central FloridaEIN 59-2142315 | Human Services | FL | $122,484,539Large | 92.92 |
| Second Harvest Food Bank of East Central IndianaEIN 31-1111795 | Human Services | IN | $14,490,604Large | 88.61 |
| Second Harvest Food Bank of East TennesseeEIN 58-1450139 | Human Services | TN | $29,394,281Large | 90.23 |
| Second Harvest Food Bank of Greater New Orleans and AcadianaEIN 72-0956468 | Human Services | LA | $73,953,206Large | 94.69 |
| Second Harvest Food Bank of MetrolinaEIN 56-1352593 | Human Services | NC | $97,534,285Large | 90.22 |
| Second Harvest Food Bank of Middle TennesseeEIN 62-1049447 | Human Services | TN | $86,355,168Large | 88.94 |
| Second Harvest Food Bank of North Central OhioEIN 34-1446685 | Human Services | OH | $11,486,199Mid-sized | 96.94 |
| Second Harvest Food Bank of Northeast TennesseeEIN 62-1303822 | Human Services | TN | $20,333,455Large | 93.56 |
| Second Harvest Food Bank of Northwest North CarolinaEIN 58-1457912 | Human Services | NC | $60,851,278Large | 96.46 |
| Second Harvest Food Bank of Northwest PennsylvaniaEIN 25-1405798 | Human Services | PA | $18,759,837Large | 92.92 |
| Second Harvest Food Bank of Orange CountyEIN 32-0362611 | Human Services | CA | $53,968,186Large | 96.80 |