| "I Have a Dream" FoundationEIN 13-3355315 | Education | NY | $4,097,195Mid-sized | 83.32 |
| I Know I CanEIN 31-1229135 | Education | OH | $4,477,894Mid-sized | 98.05 |
| I Love A Clean San Diego CountyEIN 95-2566791 | Environment | CA | $1,383,646Small | 75.88 |
| IberoAmerican MinistriesEIN 91-1563968 | Religion | WA | $2,186,442Small | 66.69 |
| Ibis Reproductive HealthEIN 03-0382773 | International | MA | $7,438,558Mid-sized | 91.51 |
| ICAEIN 41-0979010 | Human Services | MN | $4,535,690Mid-sized | 89.58 |
| ICANEIN 86-0761030 | Human Services | AZ | $1,966,281Small | 82.37 |
| ICM Food & Clothing BankEIN 86-0401223 | Human Services | AZ | $6,612,702Mid-sized | 94.28 |
| ICNA Relief USAEIN 04-3810161 | Human Services | NY | $14,885,429Large | 95.47 |
| Idaho Conservation LeagueEIN 82-6042478 | Environment | ID | $1,970,384Small | 91.68 |
| Idaho FoodbankEIN 82-0425400 | Human Services | ID | $35,648,299Large | 93.48 |
| Idaho Humane SocietyEIN 82-0212536 | Animals | ID | $5,914,266Mid-sized | 96.18 |
| Idaho Youth RanchEIN 82-0253346 | Human Services | ID | $23,775,946Large | 91.16 |
| Iditarod Trail CommitteeEIN 92-0043991 | Environment | AK | $4,642,759Mid-sized | 67.72 |
| Idyllwild Arts FoundationEIN 95-1801279 | Education | CA | $26,431,187Large | 81.19 |
| IHCF African Christian HospitalsEIN 23-7258102 | International | AR | $972,858Small | 85.39 |
| Illinois Holocaust Museum & Education CenterEIN 36-3156154 | Arts, Culture, Humanities | IL | $8,417,466Mid-sized | 85.57 |
| Illinois Network of Charter SchoolsEIN 14-1862409 | Education | IL | $2,793,417Small | 90.60 |
| Illinois Policy InstituteEIN 41-2057028 | Research and Public Policy | IL | $6,963,067Mid-sized | 84.41 |
| Illinois Valley Public Telecommunications CorporationEIN 23-7041401 | Arts, Culture, Humanities | IL | $3,110,167Small | 76.51 |
| IMA World HealthEIN 52-2112460 | International | DC | $97,151,816Large | 82.32 |
| Imagine America FoundationEIN 52-1250860 | Education | VA | $782,154Small | 67.82 |
| Imagine Children's MuseumEIN 94-3153591 | Arts, Culture, Humanities | WA | $2,018,647Small | 96.07 |
| iMentorEIN 30-0105507 | Education | NY | $18,667,266Large | 90.00 |
| Immaculate Heart CommunityEIN 95-2706764 | Religion | CA | $6,222,928Mid-sized | 90.86 |
| Immigrant Law Center of MinnesotaEIN 41-0909036 | Human and Civil Rights | MN | $2,052,064Small | 95.32 |
| Immigrant Legal Resource CenterEIN 94-2939540 | Human and Civil Rights | CA | $11,365,899Mid-sized | 92.02 |
| Immokalee Child Care CenterEIN 59-1209842 | Human Services | FL | $1,322,503Small | 91.40 |
| Immune Deficiency FoundationEIN 52-1214782 | Health | MD | $8,349,918Mid-sized | 97.17 |
| Immunization Action CoalitionEIN 41-1768237 | Health | MN | $2,652,751Small | 78.71 |
| IMPACT WITH HOPEEIN 34-1470104 | International | OH | $6,103,153Mid-sized | 84.39 |
| Imperial Valley Food PantryEIN 33-0633364 | Human Services | CA | $3,817,323Mid-sized | 71.17 |
| Impression 5 Science CenterEIN 23-7200548 | Arts, Culture, Humanities | MI | $1,619,983Small | 90.58 |
| In Touch FoundationEIN 58-2054582 | Religion | GA | $4,610,654Mid-sized | 85.55 |
| In Touch MinistriesEIN 58-1495310 | Religion | GA | $92,027,999Large | 86.14 |
| In Touch Mission InternationalEIN 94-2783852 | Religion | AZ | $1,372,833Small | 85.04 |
| INCLUDEnycEIN 11-2594790 | Human Services | NY | $2,915,236Small | 92.80 |
| Independence InstituteEIN 84-0990300 | Research and Public Policy | CO | $2,907,995Small | 91.15 |
| Independence MediaEIN 22-2600747 | Arts, Culture, Humanities | PA | $2,758,153Small | 87.44 |
| Independence Seaport MuseumEIN 23-1584971 | Arts, Culture, Humanities | PA | $5,018,524Mid-sized | 81.35 |
| Independent Catholic Foundation for the Diocese of Altoona-JohnstownEIN 25-1625390 | Religion | PA | $1,123,592Small | 96.69 |
| Independent Media InstituteEIN 52-1309876 | Arts, Culture, Humanities | NY | $2,023,149Small | 77.38 |
| India Community CenterEIN 52-2351119 | Human Services | CA | $4,360,944Mid-sized | 71.51 |
| India Development and Relief Fund, Inc. (IDRF)EIN 52-1555563 | International | MD | $1,974,078Small | 98.23 |
| India Gospel League, North AmericaEIN 31-1423556 | Religion | OH | $3,563,796Mid-sized | 93.77 |
| India Gospel OutreachEIN 33-0193797 | Religion | CA | $1,339,644Small | 85.94 |
| Indian Law Resource CenterEIN 52-1121079 | Human and Civil Rights | MT | $1,268,568Small | 92.29 |
| Indian Muslim Relief and CharitiesEIN 27-0058132 | International | CA | $5,886,673Mid-sized | 94.74 |
| Indian River Habitat for HumanityEIN 65-0230079 | Community Development | FL | $5,733,247Mid-sized | 92.16 |
| Indiana Black Expo, Inc.EIN 35-1406245 | Community Development | IN | $4,658,463Mid-sized | 78.18 |
| Indiana Historical SocietyEIN 35-0876384 | Arts, Culture, Humanities | IN | $12,091,643Mid-sized | 83.95 |
| Indiana Repertory TheatreEIN 35-1186290 | Arts, Culture, Humanities | IN | $7,233,067Mid-sized | 88.31 |
| Indianapolis Opera CompanyEIN 35-1405179 | Arts, Culture, Humanities | IN | $1,109,270Small | 68.68 |
| Indianapolis Symphony OrchestraEIN 35-0998627 | Arts, Culture, Humanities | IN | $23,290,238Large | 78.59 |
| Indianapolis Urban LeagueEIN 35-6060655 | Human and Civil Rights | IN | $2,226,625Small | 84.04 |
| Indianapolis ZooEIN 35-1074747 | Animals | IN | $32,985,416Large | 88.11 |
| InFaith Community FoundationEIN 41-1802412 | Community Development | MN | $27,770,587Large | 89.55 |
| Infant Crisis ServicesEIN 73-1378766 | Human Services | OK | $3,345,296Small | 92.89 |
| Infant Welfare Society of ChicagoEIN 36-2167752 | Health | IL | $9,544,302Mid-sized | 90.93 |
| Initiative for A Competitive Inner CityEIN 13-3772904 | Community Development | MA | $4,348,578Mid-sized | 97.05 |